玉米赤霉烯酮暴露对秀丽线虫生殖系统的损伤作用

杨振东; 王加生; 唐莉莉; 孙秀兰; Kathy S. Xue

doi:10.7524/AJE.1673-5897.20160306002

生态毒理学报

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杨振东, 王加生, 唐莉莉, 孙秀兰, Kathy S. Xue. 玉米赤霉烯酮暴露对秀丽线虫生殖系统的损伤作用[J]. 生态毒理学报, 2016, 11(6): 171-176. doi: 10.7524/AJE.1673-5897.20160306002

引用本文:

Yang Zhendong, Wang Jia-Sheng, Tang Lili, Sun Xiulan, Kathy S. Xue. The Reproductive Toxic Effects of Zearalenone on Caenorhabditis elegans[J]. Asian journal of ecotoxicology, 2016, 11(6): 171-176. doi: 10.7524/AJE.1673-5897.20160306002

Citation:

Yang Zhendong, Wang Jia-Sheng, Tang Lili, Sun Xiulan, Kathy S. Xue. The Reproductive Toxic Effects of Zearalenone on Caenorhabditis elegans[J]. Asian journal of ecotoxicology, 2016, 11(6): 171-176. doi: 10.7524/AJE.1673-5897.20160306002

玉米赤霉烯酮暴露对秀丽线虫生殖系统的损伤作用

1. 江南大学食品学院, 无锡 214122;
2. 美国佐治亚大学环境健康科学系, 佐治亚雅典 30602

作者简介: 杨振东(1986-),女,博士,研究方向为真菌毒素毒性检测,E-mail:zdyang777@163.com

通讯作者: 王加生, E-mail: jswang@uga.edu ;

基金项目:
国家自然科学基金联合基金项目(u1301214)
中图分类号: X171.5

The Reproductive Toxic Effects of Zearalenone on Caenorhabditis elegans

1. School of Food Science and Technology, Jiangnan University, Wuxi 214122, China;
2. Department of Environmental Health and Science, University of Georgia, Athens 30602, USA

Corresponding author: Wang Jia-Sheng, jswang@uga.edu ;

Fund Project:

摘要: 环境雌激素玉米赤霉烯酮(ZEN)的生态安全性近年来受到越来越多的关注。以秀丽隐杆线虫(Caenorhabdites elegans)为模式生物研究ZEN对线虫的生殖损伤作用。在DIC显微镜下观察,48 h暴露后与对照组相比,暴露组线虫性腺臂明显萎缩,卵母细胞数目和大小均受到显著影响(P<0.01),并且可见部分暴露组线虫产卵器严重畸形。这均表明ZEN暴露对秀丽隐杆线虫生殖系统的发育和功能可产生损害作用。
- 玉米赤霉烯酮 /
- 秀丽隐杆线虫 /
- 生殖损伤
Abstract: Ecological safety of zearalenone (ZEN), a potent environmental endocrine disruptor, has been a great concern. To study the reproductive toxic effects of ZEN, L2 Caenorhabdites elegans (C. elegans) were exposed to different doses of ZEN in various times. After 48 h exposure to ZEN, the morphology of the gonad arm, the vulva, and the oocytes in uterus was examined by DIC microscope. As compared to the control group, atrophic gonad arms, abnormal vulva structures and smaller oocytes were found with significantly statistical differences in worms treated with ZEN (P<0.01). The oocytes numbers and their size were significantly affected by ZEN. Worms in ZEN-treated group also showed abnormal vulva structures and defects. These results demonstrated severe damages of reproductive and developmental functions following ZEN exposure in C. elegans.
- zearalenone /
- Caenorhabditis elegans /
- reproductive damage

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Citation:

玉米赤霉烯酮暴露对秀丽线虫生殖系统的损伤作用

通讯作者: 王加生, E-mail: jswang@uga.edu ;

作者简介: 杨振东(1986-),女,博士,研究方向为真菌毒素毒性检测,E-mail:zdyang777@163.com
1. 江南大学食品学院, 无锡 214122;

2. 美国佐治亚大学环境健康科学系, 佐治亚雅典 30602

收稿日期: 2016-03-06

基金项目:

国家自然科学基金联合基金项目(u1301214)

关键词:

摘要: 环境雌激素玉米赤霉烯酮(ZEN)的生态安全性近年来受到越来越多的关注。以秀丽隐杆线虫(Caenorhabdites elegans)为模式生物研究ZEN对线虫的生殖损伤作用。在DIC显微镜下观察,48 h暴露后与对照组相比,暴露组线虫性腺臂明显萎缩,卵母细胞数目和大小均受到显著影响(P<0.01),并且可见部分暴露组线虫产卵器严重畸形。这均表明ZEN暴露对秀丽隐杆线虫生殖系统的发育和功能可产生损害作用。

English Abstract

The Reproductive Toxic Effects of Zearalenone on Caenorhabditis elegans

Corresponding author: Wang Jia-Sheng, jswang@uga.edu ;

1. School of Food Science and Technology, Jiangnan University, Wuxi 214122, China;
2. Department of Environmental Health and Science, University of Georgia, Athens 30602, USA

Received Date: 2016-03-06

Fund Project:

Keywords:

Abstract: Ecological safety of zearalenone (ZEN), a potent environmental endocrine disruptor, has been a great concern. To study the reproductive toxic effects of ZEN, L2 Caenorhabdites elegans (C. elegans) were exposed to different doses of ZEN in various times. After 48 h exposure to ZEN, the morphology of the gonad arm, the vulva, and the oocytes in uterus was examined by DIC microscope. As compared to the control group, atrophic gonad arms, abnormal vulva structures and smaller oocytes were found with significantly statistical differences in worms treated with ZEN (P<0.01). The oocytes numbers and their size were significantly affected by ZEN. Worms in ZEN-treated group also showed abnormal vulva structures and defects. These results demonstrated severe damages of reproductive and developmental functions following ZEN exposure in C. elegans.

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玉米赤霉烯酮暴露对秀丽线虫生殖系统的损伤作用

作者简介: 杨振东(1986-),女,博士,研究方向为真菌毒素毒性检测,E-mail:zdyang777@163.com

通讯作者: 王加生, E-mail: jswang@uga.edu ;

The Reproductive Toxic Effects of Zearalenone on Caenorhabditis elegans

Corresponding author: Wang Jia-Sheng, jswang@uga.edu ;

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玉米赤霉烯酮暴露对秀丽线虫生殖系统的损伤作用

通讯作者: 王加生, E-mail: jswang@uga.edu ;

作者简介: 杨振东(1986-),女,博士,研究方向为真菌毒素毒性检测,E-mail:zdyang777@163.com 1. 江南大学食品学院, 无锡 214122; 2. 美国佐治亚大学环境健康科学系, 佐治亚雅典 30602

English Abstract

The Reproductive Toxic Effects of Zearalenone on Caenorhabditis elegans

Corresponding author: Wang Jia-Sheng, jswang@uga.edu ;

全文HTML

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作者简介: 杨振东(1986-),女,博士,研究方向为真菌毒素毒性检测,E-mail:zdyang777@163.com
1. 江南大学食品学院, 无锡 214122;

2. 美国佐治亚大学环境健康科学系, 佐治亚雅典 30602