饮用水系统中抗生素抗性基因的研究进展
An overview on antibiotic resistance genes in drinking water systems
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摘要: 抗生素抗性基因(Antibiotic resistance genes,ARGs)在饮用水系统中的传播和扩散已成为全球公共健康的主要威胁之一.饮用水厂处理工艺对抗生素抗性基因的去除效果对保证饮用水水质安全具有重要意义,但是水处理工艺、消毒方式以及管网输配系统对不同抗生素抗性基因的影响差异较大.本文在总结了大量文献的基础上,阐述了饮用水系统中抗生素抗性基因的污染特征,综述了臭氧、混凝、砂滤、生物活性炭以及氯消毒和超滤膜等不同水处理工艺对抗生素抗性基因去除的影响及其机理.Abstract: The spread of antibiotic resistance genes(ARGs) in the drinking water systems has been considered as a major public health issue around the world. Drinking water treatment processes are of great significance for removing antibiotic resistance genes to ensure the safety of drinking water. However, water treatment techniques, disinfection methods and drinking water distribution systems have distinct impacts on different antibiotic resistance genes. On the basis of previous literatures, this paper summarized the pollution characteristics of antibiotic resistance genes and research progress in the drinking water systems. The effects on the removal of the antibiotic resistance genes and their mechanisms by different water treatment processes, including ozonation, coagulation/flocculation, sand filtration, biological activated carbon (BAC), ultrafiltration membrane and chlorination were reviewed.
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[1] 罗义,周启星. 抗生素抗性基因(ARGs)——一种新型环境污染物[J].环境科学学报, 2008, 28(8):1499-1505. LUO Y,ZHOU Q X.Antibiotic resistance genes (ARGs) as emerging pollutants[J].Acta Scientiae Circumstantiae, 2008, 28(8):1499-1505(in Chinese).
[2] PRUDEN A, PEI R, STORTEBOOM H, et al. Antibiotic resistance genes as emerging contaminants:Studies in Northern Colorado[J]. Environmental Science and Technology, 2006, 40(23):7445-7450. [3] TAO R, YING G G, SU H C, et al. Detection of antibiotic resistance and tetracycline resistance genes in Enterobacteriaceae isolated from the Pearl rivers in South China[J]. Environmental Pollution, 2010, 158(6):2101-2109. [4] RAM S, VAJPAYEE P, SINGH R L, et al. Surface water of a perennial river exhibits multi-antimicrobial resistant shiga toxin and enterotoxin producing Escherichia coli[J]. Ecotoxicology and Environmental Safety, 2008, 72(2):490-495. [5] LUO Y, MAO D, RYSZ M, et al. Trends in antibiotic resistance genes occurrence in the Haihe River, China[J]. Environmental Science and Technology, 2010, 44(19):7220-7225. [6] GUNNARSD TTIR R, JENSSEN P D, JENSEN P E, et al. A review of wastewater handling in the Arctic with special reference to pharmaceuticals and personal care products (PPCPs) and microbial pollution[J]. Ecological Engineering, 2013, 50(8):76-85. [7] GRAHAM D W, OLIVARESRIEUMONT S, KNAPP C W, et al. Antibiotic resistance gene abundances associated with waste discharges to the Almendares River near Havana, Cuba[J]. Environmental Science and Technology, 2011, 45(2):418-424. [8] ZOU S C, ZHU C J, HE Z M, et al. Preliminary studies on the pollution levels of antibiotic resistance genes in the water of Beijiang River, South China[J]. Asian Journal of Ecotoxicology, 2009, 4(5):655-660. [9] HENRIQUES I, MOURA A, ALVES A, et al. Analysing diversity among β-lactamase encoding genes in aquatic environments[J]. FEMS Microbiology Ecology, 2006, 56(3):418-429. [10] AGERS Y,PETERSEN A. The tetracycline resistance determinant tet 39 and the sulphonamide resistance gene sulⅡ are common among resistant Acinetobacter spp. isolated from integrated fish farms in Thailand[J]. Food Quality and Preference, 2007, 59(1):23-27. [11] DANG H, ZHANG X, SONG L, et al. Molecular characterizations of oxytetracycline resistant bacteria and their resistance genes from mariculture waters of China[J]. Marine Pollution Bulletin, 2006, 52(11):1494-1503. [12] JACOBS L,CHENIA H Y. Characterization of integrons and tetracycline resistance determinants in Aeromonas spp. isolated from South African aquaculture systems[J]. Oncology Reports, 2007, 114(3):295-306. [13] DANG H, ZHANG X, SONG L, et al. Molecular determination of oxytetracycline-resistant bacteria and their resistance genes from mariculture environments of China[J]. Journal of Applied Microbiology, 2007, 103(6):2580-2592. [14] AUERBACH E A, SEYFRIED E E, MCMAHON K D. Tetracycline resistance genes in activated sludge wastewater treatment plants[J]. Water Research, 2007, 41(5):1143-1151. [15] VOLKMANN H, SCHWARTZ T, BISCHOFF P. Detection of clinically relevant antibiotic-resistance genes in municipal wastewater using RealTime PCR (TaqMan)[J]. Journal of Microbiological Methods, 2004, 56(2):277-286. [16] MUNIR M, WONG K, XAGORARAKI I. Release of antibiotic resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan[J]. Water Research, 2011, 45(2):681-693. [17] ŁUCZKIEWICZ A, JANKOWSKA K, FUDALA-KSIAEK S, et al. Antimicrobial resistance of fecal indicators in municipal wastewater treatment plant[J]. Water Research, 2010, 44(17):5089-5097. [18] CHEN J, MICHEL F C, SREEVATSAN S, et al. Occurrence and persistence of erythromycin resistance genes (erm) and tetracycline resistance genes (tet) in waste treatment systems on Swine Farms[J]. Microbial Ecology, 2010, 60(3):479-486. [19] FUENTEFRIA D B, FERREIRA A E, COR O G. Antibiotic-resistant Pseudomonas aeruginosa from hospital wastewater and superficial water:Are they genetically related?[J]. Journal of Environmental Management, 2010, 92(1):250-255. [20] HONG A D, PHAM N H, NGUYEN H T, et al. Occurrence, fate and antibiotic resistance of fluoroquinolone antibacterials in hospital wastewaters in Hanoi, Vietnam[J]. Chemosphere, 2008, 72(6):968-973. [21] CHAPIN A,SCHWAB K. Airborne multidrug-resistant bacteria isolated from a concentrated swine feeding operation[J]. Environmental Health Perspectives, 2005, 113(2):137-142. [22] YAN G, VEILLETTE M, DUCHAINE C. Airborne bacteria and antibiotic resistance genes in hospital rooms[J]. Aerobiologia, 2010, 26(3):185-194. [23] GANDOLFI I, FRANZETTI A, BERTOLINI V, et al. Antibiotic resistance in bacteria associated with coarse atmospheric particulate matter in an urban area[J]. Journal of Applied Microbiology, 2011, 110(6):1612-1620. [24] LIS D O, PACHA J Z, IDZIK D. Methicillin resistance of airborne coagulase-negative staphylococci in homes of persons having contact with a hospital environment[J]. American Journal of Infection Control, 2009, 37(3):177-182. [25] MARQUES A M, CONGREGADO F, SIMONPUJOL D M. Antibiotic and heavy metal resistance of Pseudomonas aeruginosa isolated from soils[J]. Journal of Applied Bacteriology, 1979, 47(2):347-350. [26] JI X, SHEN Q, FANG L, et al. Antibiotic resistance gene abundances associated with antibiotics and heavy metals in animal manures and agricultural soils adjacent to feedlots in Shanghai; China[J]. Journal of Hazardous Materials, 2012, 235(20):178-185. [27] BARTON B C, MODY R K, JUNGK J, et al. 2008 outbreak of Salmonella Saintpaul infections associated with raw produce[J]. New England Journal of Medicine, 2011, 364(10):918-927. [28] YONG D, TOLEMAN M A, GISKE C G, et al. Characterization of a new metallo-β-lactamase gene, blaNDM-1, and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India[J]. Antimicrobial Agents and Chemotherapy, 2009, 53(12):5046-5054. [29] 苏建强, 黄福义, 朱永官. 环境抗生素抗性基因研究进展[J].生物多样性, 2013, 21(4):481-487. SU J Q,HUANG F Y,ZHU Y G.Antibiotic resistance genes in the environment[J].Biodiversity Science, 2013, 21(4):481-487(in Chinese).
[30] YU P Y, LIN Y E, LIN W R, et al. The high prevalence of Legionella pneumophila contamination in hospital potable water systems in Taiwan:Implications for hospital infection control in Asia[J]. International Journal of Infectious Diseases, 2008, 12(4):416-420. [31] 李青青. 调查证明美国饮用水中存在痕量药物[J].中国环境科学, 2009,29(5):523. LI Q Q. Investigation proved that trace amounts of drugs in the United States drinking water[J].China Environmental Science, 2009 ,29(5):523(in Chinese).
[32] STOLL C, SIDHU J P, TIEHM A, et al. Prevalence of clinically relevant antibiotic resistance genes in surface water samples collected from Germany and Australia[J]. Environmental Science and Technology, 2012, 46(17):9716-9726. [33] CZEKALSKI N, BERTHOLD T, CAUCCI S, et al. Increased levels of multiresistant bacteria and resistance genes after wastewater treatment and their dissemination into Lake Geneva, Switzerland[J]. Frontiers in Microbiology, 2012, 3:106-106. [34] XI C, ZHANG Y, MARRS C F, et al. Prevalence of antibiotic resistance in drinking water treatment and distribution systems[J]. Applied and Environmental Microbiology, 2009, 75(17):5714-5718. [35] CHEN B, LIANG X, HUANG X, et al. Differentiating anthropogenic impacts on ARGs in the Pearl River Estuary by using suitable gene indicators[J]. Water Research, 2013, 47(8):2811-2820. [36] ZHANG X, BING W, YAN Z, et al. Class 1 integronase gene and tetracycline resistance genes tet A and tet C in different water environments of Jiangsu Province, China[J]. Ecotoxicology, 2009, 18(6):652-660. [37] JIANG L, HU X, XU T, et al. Prevalence of antibiotic resistance genes and their relationship with antibiotics in the Huangpu River and the drinking water sources, Shanghai, China[J]. Science of the Total Environment, 2013, 458-460(3):267-272. [38] 王青, 林惠荣, 张舒婷, 等. 九龙江下游水源水中新发病原微生物和抗生素抗性基因的定量PCR检测[J].环境科学, 2012, 33(8):2685-2690. WANG Q,LIN H R,ZHANG S T,et al. Real-time PCR detection and quantification of emerging waterborne pathogens (EWPs) and antibiotic resistance genes(ARGs) in the downstream area ofJiulong River[J].Environment Science, 2012, 33(8):2685-2690(in Chinese).
[39] GUO X, LI J, YANG F, et al. Prevalence of sulfonamide and tetracycline resistance genes in drinking water treatment plants in the Yangtze River Delta, China[J]. Science of the Total Environment, 2014, 493:626-631. [40] XU L, OUYANG W, QIAN Y, et al. High-throughput profiling of antibiotic resistance genes in drinking water treatment plants and distribution systems[J]. Environmental Pollution, 2016, 213:119-126. [41] FALCONE-DIAS M F, VAZ-MOREIRA I, MANAIA C M. Bottled mineral water as a potential source of antibiotic resistant bacteria[J]. Water Research, 2012, 46(11):3612-3622. [42] PRUDEN A, ARABI M, STORTEBOOM H N. Correlation between upstream human activities and riverine antibiotic resistance genes[J]. Environmental Science and Technology, 2012, 46(21):11541-11549. [43] CHEN J, YU Z, JR M F, et al. Development and application of real-time PCR assays for quantification of erm genes conferring resistance to macrolides-lincosamides-streptogramin B in livestock manure and manure management systems[J]. Agrokémia És Talajtan, 2007, 73(14):119-127. [44] ZHANG X X,ZHANG T. Occurrence, abundance, and diversity of tetracycline resistance genes in 15 sewage treatment plants across China and other global locations[J]. Environmental Science and Technology, 2011, 45(7):2598-2604. [45] AINA IVERSEN I K A F R M. High prevalence of vancomycin-resistant enterococci in Swedish Sewage[J]. Applied and Environmental Microbiology, 2002, 68(6):2838-2842. [46] CAPLIN J L, HANLON G W, TAYLOR H D. Presence of vancomycin and ampicillin-resistant Enterococcusfaecium of epidemic clonal complex-17 in wastewaters from the south coast of England[J]. Environmental Microbiology, 2008, 10(4):885-892. [47] HEBERER T,STAN H J. Determination of clofibric acid and N-(phenylsulfonyl)-sarcosine in sewage, river and drinking water[J]. International Journal of Environmental Analytical Chemistry, 1997, 67(1/4):113-124. [48] CARBALLA M, OMIL F, LEMA J M, et al. Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant[J]. Water Research, 2004, 38(12):2918-2926. [49] ZHANG T, ZHANG M, ZHANG X, et al. Tetracycline resistance genes and tetracycline resistant lactose-fermenting Enterobacteriaceae in activated sludge of sewage treatment plants[J]. Environmental Science and Technology, 2009, 43(10):3455-3460. [50] 王丽梅, 罗义, 毛大庆, 等. 抗生素抗性基因在环境中的传播扩散及抗性研究方法[J].应用生态学报, 2010, 21(4):1063-1069. WANG L M,LUO Y,MAO D Q,et al. Transport of antibiotic resistance genes in environment and detection methods of antibiotic resistance[J]. Chinese Journal of Applied Ecology, 2010, 21(4):1063-1069(in Chinese).
[51] KIM S, PARK H, CHANDRAN K. Propensity of activated sludge to amplify or attenuate tetracycline resistance genes and tetracycline resistant bacteria:A mathematical modeling approach[J]. Chemosphere, 2010, 78(9):1071-1077. [52] 马丽丽, 郭昌胜, 胡伟, 等. 固相萃取-高效液相色谱-串联质谱法同时测定土壤中氟喹诺酮、四环素和磺胺类抗生素[J].分析化学, 2010, 38(1):21-26. MA L L,GUO C S,HU W,et al. Solid phase extraction-high performance liquid chromatography-tandem mass spectrometry determination of fluoroquinolone, tetracycline and sulfa antibiotics in soil[J].Chinese Journal of Analytical Chemistry, 2010, 38(1):21-26(in Chinese).
[53] YANG S,CARLSON K. Evolution of antibiotic occurrence in a river through pristine, urban and agricultural landscapes[J]. Water Research, 2003, 37(19):4645-4656. [54] SILVA M F D, VAZ-MOREIRA I, GONZALEZ-PAJUELO M, et al. Antimicrobial resistance patterns in Enterobacteriaceae isolated from an urban wastewater treatment plant[J]. FEMS Microbiology Ecology, 2007, 60(1):166-176. [55] TAVIANI E, CECCARELLI D, LAZARO N, et al. Environmental Vibrio spp., isolated in Mozambique, contain a polymorphic group of integrative conjugative elements and class 1 integrons[J]. FEMS Microbiology Ecology, 2008, 64(1):45-54. [56] SCHWARTZ T, KOHNEN W, JANSEN B, et al. Detection of antibiotic-resistant bacteria and their resistance genes in wastewater, surface water, and drinking water biofilms[J]. FEMS Microbiology Ecology, 2003, 43(3):325-335. [57] SZCZEPANOWSKI R, BRAUN S, RIEDEL V, et al. The 120592 bp IncF plasmid pRSB107 isolated from a sewage-treatment plant encodes nine different antibiotic-resistance determinants, two iron-acquisition systems and other putative virulence-associated functions[J]. Microbiology, 2005, 151(4):1095-1111. [58] LI D, ZENG S, HE M, et al. Water disinfection byproducts induce antibiotic resistance-role of environmental pollutants in resistance phenomena[J]. Environmental Science and Technology, 2016, 50(6):3193-3201. [59] 白晓慧, 朱斌, 王海亮. 城市供水水质生物稳定性与管网微生物生长相关性研究进展[J].净水技术, 2006, 25(4):1-4. BAI X H,ZHU B,WANG H L. Relationship between urban water biological stability and the microbes growth on pipe wall[J]. Water Purification Technology, 2006, 25(4):1-4(in Chinese).
[60] 贾江雁,李明利. 抗生素在环境中的迁移转化及生物效应研究进展[J].四川环境, 2011, 30(1):121-125. JIA J Y,LI M L. A review on antibiotics migration-transportation and Biological effect in envirornnent[J].Sichuan Environment, 2011, 30(1):121-125(in Chinese).
[61] 王海亮,钱庆玲,胡龙羊.臭氧在给水处理中的应用[J]. 公用科技, 1998, 14(3):20-23. WANG H L, QIAN Q L, HU L Y.The application of ozone in water treatment[J]. Public Technology, 1998, 14(3):20-23(in Chinese).
[62] BÖCKELMANN U, DÖRRIES H H, AYUSO-GABELLA M N, et al. Quantitative PCR monitoring of antibiotic resistance genes and bacterial pathogens in three European artificial groundwater recharge systems[J]. Applied and Environmental Microbiology, 2009, 75(1):154-163. [63] PRUDEN A. Balancing water sustainability and public health goals in the face of growing concerns about antibiotic resistance[J]. Environmental Science and Technology, 2014, 48(1):5-14. [64] SHI P, JIA S, ZHANG X X, et al. Metagenomic insights into chlorination effects on microbial antibiotic resistance in drinking water[J]. Water Research, 2013, 47(1):111-120. [65] ARMSTRONG J L, SHIGENO D S, CALOMIRIS J J, et al. Antibiotic-resistant bacteria in drinking water[J]. Applied and Environmental Microbiology, 1981, 42(2):277-283. [66] MURRAY G E, TOBIN R S, JUNKINS B, et al. Effect of chlorination on antibiotic resistance profiles of sewage-related bacteria[J]. Applied and Environmental Microbiology, 1984, 48(1):73-77. [67] RUTALA W A, STIEGEL M M, SARUBBI F A, et al. Susceptibility of antibiotic-susceptible and antibiotic-resistant hospital bacteria to disinfectants[J]. Infection Control and Hospital Epidemiology, 1997, 18(6):417-421. [68] 张明露, 周贺, 关磊, 等. 饮用水配水系统中微生物研究方法的进展[J].环境与健康杂志, 2015, 32(5):458-462. ZHANG M L,ZHOU H,GUAN L,et al. Microbes in drinking water distribution systems:A review of recent studies[J].Journal of Environment and Health, 2015, 32(5):458-462(in Chinese).
[69] SCHL TER A, SZCZEPANOWSKI R, P HLER A, et al. Genomics of IncP-1 antibiotic resistance plasmids isolated from wastewater treatment plants provides evidence for a widely accessible drug resistance gene pool[J]. FEMS Microbiology Reviews, 2007, 31(4):449-477. [70] TENNSTEDT T, SZCZEPANOWSKI R, BRAUN S, et al. Occurrence of integron-associated resistance gene cassettes located on antibiotic resistance plasmids isolated from a wastewater treatment plant[J]. FEMS Microbiology Ecology, 2003, 45(3):239-252. [71] MERLIN C, BONOT S, COURTOIS S, et al. Persistence and dissemination of the multiple-antibiotic-resistance plasmid pB10 in the microbial communities of wastewater sludge microcosms[J]. Water Research, 2011, 45(9):2897-2905. [72] 秦丽婷,童蕾,刘慧,等.环境中磺胺类抗生素的生物降解及其抗性基因污染现状[J].环境化学,2016,35(5):875-883. QIN L T,TONG L.LIU H,et al.Biodegradation of sulfonamides and the pollution characteristics of sulfonamide resistance genes in the environment[J].Environmental Chemistry, 2016,35(5):875-883(in Chinese).
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