新冠肺炎疫情防控对城市毒品滥用的影响
Wastewater-based epidemiology studies of drug abuse in donggang during COVID-19
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摘要: 为了调查疫情期间区域毒品滥用情况变化,采用污水流行病学方法,于2020年4月在辽宁省东港市污水处理厂和4个主要污水泵站以及泵站服务的9个居民小区采集了污水样品.通过气相色谱衍生化方法分析代表性毒品甲基苯丙胺的浓度,结合相关数学模型估算其滥用量、流行率、滥用人数,使用蒙特卡罗法分析不确定性,并与疫情前2019年6月的监测结果进行对比.结果表明,疫情期间辽宁省东港市污水中甲基苯丙胺的浓度范围为16-130 ng·L-1,平均值为68.7 ng·L-1,采样地点人均滥用量为73.4 μg·d-1(95% CI:58.1-91.4),流行率为0.25%(95% CI:0.18-0.33),滥用人数为1583人(95% CI:1159-2110);与疫情前2019年6月对比,疫情期间甲基苯丙胺的滥用量、流行率、滥用人数均下降79%.Abstract: Wastewater-based epidemiology (WBE) was employed to investigate the change of regional drug abuse during COVID-19. In April 2020, the wastewater samples were collected from one wastewater treatment plant (WWTP), four wastewater lift stations and nine residential communities served by these wastewater lift stations in Donggang, Liaoning Province. A gas chromatography-mass spectrometry method was developed for the determination of the concentrations of methamphetamine, coupled with relevant mathematical models, the consumption of methamphetamine, the prevalence and the number of methamphetamine abusers were estimated. The Monte Carlo method was used to analyze uncertainty, and the monitoring results were compared with the results found in June 2019 before COVID-19 pandemic. It was shown that the concentrations of methamphetamine in wastewater in Donggang was estimated to be 16-130 ng·L-1, the mean was 68.7 ng·L-1, the per capita consumption was 73.4 μg·d-1 (95% CI:58.1-91.4), the prevalence was 0.25% (95% CI:0.18-0.33), and the number of methamphetamine abusers was 1583 (95% CI:1159-2110). Compared with the results estimated in June 2019 before the pandemic, the consumption of methamphetamine, the prevalence and the number of methamphetamine abusers declined by 79% during the pandemic.
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Key words:
- COVID-19 /
- prevention and control /
- wastewater-based epidemiology /
- methamphetamine
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