胡萝卜中滴滴涕对人体生物有效性影响因素的体外研究

陆敏; 余应新; 张东平; 张帆; 韩姝媛; 吴明红; 盛国英; 傅家谟

上海大学环境与化学工程学院环境污染与健康研究所, 上海， 200072;

上海大学环境与化学工程学院射线应用研究所，上海， 200444;

中国科学院广州地球化学研究所, 有机地球化学国家重点实验室, 广东省环境资源利用与保护重点实验室, 广州, 510640

基金项目:

上海市教委基金项目(06AZ064)

上海高校优秀青年教师后备人选项目

上海市重点学科(S3019)

国家重点基础研究计划项目(2008CB18205)资助

EFFECT FACTOR ANALYSIS OF BIOACCESSIBILITY OF DDTs IN CARROT TO HUMAN USING AN IN VITRO MODEL

Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200072, China;

Institute of Applied Radiation, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China;

State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environmental Resources Utilizationand Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China

Fund Project:

摘要: 采用基于生理学的体外实验,通过模拟人体胃和小肠的环境,分析了胡萝卜中p,p'-DDT,p,p'-DDD和p,p'-DDE在人体胃肠系统的生物有效性.结果表明,DDTs在小肠环境下的生物有效性大于胃环境,胆汁和胰液对生物有效性有正影响;当胡萝卜的质量恒定时,p,p'-DDE,p,p'-DDD和p,p'-DDT在胃和小肠中的生物有效性不随其浓度的变化而变化,它们在胃和小肠中的生物有效性分别为12.72%,12.71%,11.99%和47.14%,41.16%,46.29%.然而,当p,p'-DDT,p,p'-DDD和p,p'-DDE的量恒定时,其生物有效性随胡萝卜质量的增大而减小,且两者之间呈现对数关系.

Abstract: The bioaccessibility of p,p'-DDT,p,p'-DDD and p,p'-DDE in the polluted carrot were analyzed using a physiologically based in vitro test by simulating the human gastro-intestinal tract.The study results showed that the bioaccessibilities of p,p'-DDT,p,p'-DDD and p,p'-DDE in intestinal solution were higher than in stomach,and the bile and pancreatin had positive effects to them.When 0.12 g carrot with different p,p'-DDE,p,p'-DDD and p,p'-DDT concentrations were added and digested in the simulating solution,the bioaccessibility of them were always 12.72%,12.71% and 11.99% in stomach solution and,47.14%,41.16% and 46.29% in intestinal solution,respectively.However,the bioaccessibility of them decreased along with the increasing of the mass of carrot,when the same quality of p,p'-DDT,p,p'-DDD and p,p'-DDE were used.Moreover,distinguish logarithmic correlations were found between the bioaccessibility of DDTs and the mass of carrot.

Key words:

carrot /
DDTs /
in vitro /
bioaccessibility /
stomach /
intestine

胡萝卜中滴滴涕对人体生物有效性影响因素的体外研究

1. 上海大学环境与化学工程学院环境污染与健康研究所, 上海， 200072;

2. 上海大学环境与化学工程学院射线应用研究所，上海， 200444;

3. 中国科学院广州地球化学研究所, 有机地球化学国家重点实验室, 广东省环境资源利用与保护重点实验室, 广州, 510640

基金项目:

上海市教委基金项目(06AZ064)

上海高校优秀青年教师后备人选项目

上海市重点学科(S3019)

国家重点基础研究计划项目(2008CB18205)资助

关键词:

胡萝卜 /
DDTs /
体外实验 /
生物有效性 /
胃 /
肠

EFFECT FACTOR ANALYSIS OF BIOACCESSIBILITY OF DDTs IN CARROT TO HUMAN USING AN IN VITRO MODEL

1. Institute of Environmental Pollution and Health, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200072, China;

2. Institute of Applied Radiation, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China;

3. State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environmental Resources Utilizationand Protection, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China

Fund Project:

Keywords:

carrot /
DDTs /
in vitro /
bioaccessibility /
stomach /
intestine

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