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图 1 9-Fluorenone暴露诱导肝癌细胞侵袭和迁移的发生(*** P<0.001)
Figure 1. The invasion and migration of hepatocellular carcinoma cells induced by 9-Fluorenone exposure(*** P<0.001)
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图 2 9-Fluorenone暴露诱导肝癌细胞EMT发生(** P<0.01)
Figure 2. The epithelial-mesenchymal transition (EMT) of hepatocellular carcinoma cells induced by 9-Fluorenone exposure(** P<0.01)
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图 3 9-Fluorenone暴露通过肝癌细胞MST-LATS级联效应诱导Hippo-YAP通路失调(* P<0.05, ** P<0.01)
Figure 3. 9-Fluorenone exposure disrupted the MST-LATS cascade and induced Hippo-YAP pathway dysfunction in hepatocellular carcinoma cells(* P<0.05, ** P<0.01)
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图 4 9-Fluorenone暴露诱导肝癌细胞YAP-TEAD的结合
Figure 4. 9-Fluorenone exposure induced the interaction of YAP and TEAD in hepatocellular carcinoma cells
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图 5 YAP-TEAD抑制剂处理对9-Fluorenone诱导的肝癌细胞EMT和侵袭转移效应的影响(与对照组比较**P<0.01, ***P<0.001; 与9-F组比较 #P<0.05)
Figure 5. The effects of YAP-TEAD inhibitor treatment on EMT and invasion and metastasis of hepatocellular carcinoma cells induced by 9-Fluorenone(**P<0.01,***P<0.001 vs control group;#P<0.05 vs 9-FL group)
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