全氟和多氟烷基物质在人体生物样本中的检测方法与暴露水平研究进展

江建明; 李敏杰; 叶铖; 罗海威; 洪文俊; 郭良宏

doi:10.7524/j.issn.0254-6108.2023101001

[1]

HU X C, ANDREWS D Q, LINDSTROM A B, et al. Detection of poly- and perfluoroalkyl substances (PFASs) in U. S. drinking water linked to industrial sites, military fire training areas, and wastewater treatment plants[J]. Environmental Science & Technology Letters, 2016, 3(10): 344-350.

[2]

WANG Z Y, COUSINS I T, SCHERINGER M, et al. Global emission inventories for C4-C14 perfluoroalkyl carboxylic acid (PFCA) homologues from 1951 to 2030, Part I: Production and emissions from quantifiable sources[J]. Environment International, 2014, 70: 62-75. doi: 10.1016/j.envint.2014.04.013

[3]

KURWADKAR S, DANE J, KANEL S R, et al. Per- and polyfluoroalkyl substances in water and wastewater: A critical review of their global occurrence and distribution[J]. Science of the Total Environment, 2022, 809: 151003. doi: 10.1016/j.scitotenv.2021.151003

[4]

WANG Y X, ZHONG Y X, LI J G, et al. Occurrence of perfluoroalkyl substances in matched human serum, urine, hair and nail[J]. Journal of Environmental Sciences, 2018, 67: 191-197. doi: 10.1016/j.jes.2017.08.017

[5]

GEBBINK W A, GLYNN A, DARNERUD P O, et al. Perfluoroalkyl acids and their precursors in Swedish food: The relative importance of direct and indirect dietary exposure[J]. Environmental Pollution, 2015, 198: 108-115. doi: 10.1016/j.envpol.2014.12.022

[6]

RAND A A, ROONEY J P, BUTT C M, et al. Cellular toxicity associated with exposure to perfluorinated carboxylates (PFCAs) and their metabolic precursors[J]. Chemical Research in Toxicology, 2014, 27(1): 42-50. doi: 10.1021/tx400317p

[7]

HAGENAARS A, VERGAUWEN L, de COEN W, et al. Structure-activity relationship assessment of four perfluorinated chemicals using a prolonged zebrafish early life stage test[J]. Chemosphere, 2011, 82(5): 764-772. doi: 10.1016/j.chemosphere.2010.10.076

[8]

PENG L, XU W, ZENG Q H, et al. Exposure to perfluoroalkyl substances in waste recycling workers: Distributions in paired human serum and urine[J]. Environment International, 2022, 158: 106963. doi: 10.1016/j.envint.2021.106963

[9]

Programme United Nations Environment. New POPs SC-4/17: Listing of perfluorooctane sulfonic acid, its salts and perfluorooctane sulfonyl fluoride[R]. 2010.

[10]

CAO Z J, LIN S B, ZHAO F, et al. Cohort profile: China National Human Biomonitoring (CNHBM)—a nationally representative, prospective cohort in Chinese population[J]. Environment International, 2021, 146: 106252. doi: 10.1016/j.envint.2020.106252

[11]

罗新月, 赵璇, 任琳, 等. 尿液中12种全氟化合物的固相萃取-超高效液相色谱串联四极杆线性离子阱质谱分析方法研究[J]. 四川大学学报(医学版), 2021, 52(4): 679-685. LUO X Y, ZHAO X, REN L, et al. Study on the analytical method of solid phase extraction-ultra performance liquid chromatography tandem quadrupole linear ion trap mass spectrometry for 12 perfluorinated compounds in human urine[J]. Journal of Sichuan University (Medical Sciences), 2021, 52(4): 679-685 (in Chinese).

[12]

MAO P, WANG D J. Biomonitoring of perfluorinated compounds in a drop of blood[J]. Environmental Science & Technology, 2015, 49(11): 6808-6814.

[13]

GAO K, FU J J, XUE Q, et al. An integrated method for simultaneously determining 10 classes of per- and polyfluoroalkyl substances in one drop of human serum[J]. Analytica Chimica Acta, 2018, 999: 76-86. doi: 10.1016/j.aca.2017.10.038

[14]

谢琳娜, 张海婧, 侯沙沙, 等. 人血清中18种全氟烷烃化合物 UPLC-MS/MS的测定[J]. 环境卫生学杂志, 2019, 9(5): 494-501. XIE L N, ZHANG H J, HOU S S, et al. Determination of 18 perfluoroalkyl substances in human serum by UPLC-MS/MS[J]. Journal of Environmental Hygiene, 2019, 9(5): 494-501 (in Chinese).

[15]

WU M H, SUN R, WANG M N, et al. Analysis of perfluorinated compounds in human serum from the general population in Shanghai by liquid chromatography-tandem mass spectrometry (LC-MS/MS)[J]. Chemosphere, 2017, 168: 100-105. doi: 10.1016/j.chemosphere.2016.09.161

[16]

SO M K, TANIYASU S, LAM P K S, et al. Alkaline digestion and solid phase extraction method for perfluorinated compounds in mussels and oysters from South China and Japan[J]. Archives of Environmental Contamination and Toxicology, 2006, 50(2): 240-248. doi: 10.1007/s00244-005-7058-x

[17]

宋小飞, 施召才, 马伟文, 等. 液相色谱-质谱联用法测定血液中全氟化合物[J]. 分析试验室, 2020, 39(1): 53-56. SONG X F, SHI Z C, MA W W, et al. Determination of perfluorinated compounds in blood by liquid chromatographymass spectrometry[J]. Chinese Journal of Analysis Laboratory, 2020, 39(1): 53-56 (in Chinese).

[18]

王姮, 胡红美, 郭远明, 等. 水产品中有机锡类化合物检测方法研究进展[J]. 食品安全质量检测学报, 2019, 10(21): 7245-7252. WANG H, HU H M, GUO Y M, et al. Research progress of detection methods of organotin compounds in aquatic products[J]. Journal of Food Safety & Quality, 2019, 10(21): 7245-7252 (in Chinese).

[19]

MATHURIN J C, de CEAURRIZ J, AUDRAN M, et al. Detection of perfluorocarbons in blood by headspace solid-phase microextraction combined with gas chromatography/mass spectrometry[J]. Biomedical Chromatography:BMC, 2001, 15(7): 443-451. doi: 10.1002/bmc.79

[20]

DENG J W, YANG Y Y, FANG L, et al. Coupling solid-phase microextraction with ambient mass spectrometry using surface coated wooden-tip probe for rapid analysis of ultra trace perfluorinated compounds in complex samples[J]. Analytical Chemistry, 2014, 86(22): 11159-11166. doi: 10.1021/ac5034177

[21]

顾奕, 郭明, 吕达, 等. 毛细管电泳法考察全氟辛酸与人血清白蛋白的相互作用[J]. 色谱, 2018, 36(1): 69-77. doi: 10.3724/SP.J.1123.2017.09041 GU Y, GUO M, LV D, et al. Investigation on the interaction between pentadecafluorooctanoic acid and human serum albumin by capillary electrophoresis[J]. Chinese Journal of Chromatography, 2018, 36(1): 69-77 (in Chinese). doi: 10.3724/SP.J.1123.2017.09041

[22]

WU N, CAI D M, GUO M J, et al. Per- and polyfluorinated compounds in saleswomen’s urine linked to indoor dust in clothing shops[J]. Science of the Total Environment, 2019, 667: 594-600. doi: 10.1016/j.scitotenv.2019.02.287

[23]

MOTAS GUZMÀN M, CLEMENTINI C, PÉREZ-CÁRCELES M D, et al. Perfluorinated carboxylic acids in human breast milk from Spain and estimation of infant’s daily intake[J]. Science of the Total Environment, 2016, 544: 595-600. doi: 10.1016/j.scitotenv.2015.11.059

[24]

FUJII Y, YAN J X, HARADA K H, et al. Levels and profiles of long-chain perfluorinated carboxylic acids in human breast milk and infant formulas in East Asia[J]. Chemosphere, 2012, 86(3): 315-321. doi: 10.1016/j.chemosphere.2011.10.035

[25]

ZHANG J J, JASPERS V L B, RØE J, et al. Per- and poly-fluoroalkyl substances in Tawny Owl (Strix aluco) feathers from Trøndelag, Norway[J]. Science of the Total Environment, 2023, 903: 166213. doi: 10.1016/j.scitotenv.2023.166213

[26]

肖永华, 梁高道, 革丽亚, 等. 固相萃取-超高效液相色谱/串联质谱法测定人体血清中7种全氟化合物[J]. 分析科学学报, 2015, 31(5): 646-650. XIAO Y H, LIANG G D, GE L Y, et al. Determination of seven perfluorinated compounds in human serum by ultra performance liquid chromatography-tandem mass spectrometry combined with solid phase extraction[J]. Journal of Analytical Science, 2015, 31(5): 646-650 (in Chinese).

[27]

LIU D X, TANG B, NIE S S, et al. Distribution of per- and poly-fluoroalkyl substances and their precursors in human blood[J]. Journal of Hazardous Materials, 2023, 441: 129908. doi: 10.1016/j.jhazmat.2022.129908

[28]

LIAO Q, TANG P, PAN D X, et al. Association of serum per- and polyfluoroalkyl substances and gestational anemia during different trimesters in Zhuang ethnic pregnancy women of Guangxi, China[J]. Chemosphere, 2022, 309: 136798. doi: 10.1016/j.chemosphere.2022.136798

[29]

LI Y J, CHENG Y T, XIE Z Y, et al. Perfluorinated alkyl substances in serum of the southern Chinese general population and potential impact on thyroid hormones[J]. Scientific Reports, 2017, 7: 43380. doi: 10.1038/srep43380

[30]

ZENG X W, QIAN Z M, VAUGHN M, et al. Human serum levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in Uyghurs from Sinkiang-Uighur Autonomous Region, China: Background levels study[J]. Environmental Science and Pollution Research, 2015, 22(6): 4736-4746. doi: 10.1007/s11356-014-3728-4

[31]

GUO F F, ZHONG Y X, WANG Y X, et al. Perfluorinated compounds in human blood around Bohai Sea, China[J]. Chemosphere, 2011, 85(2): 156-162. doi: 10.1016/j.chemosphere.2011.06.038

[32]

BJERREGAARD-OLESEN C, BACH C C, LONG M H, et al. Time trends of perfluorinated alkyl acids in serum from Danish pregnant women 2008-2013[J]. Environment International, 2016, 91: 14-21. doi: 10.1016/j.envint.2016.02.010

[33]

ERIKSSON U, MUELLER J F, TOMS L M L, et al. Temporal trends of PFSAs, PFCAs and selected precursors in Australian serum from 2002 to 2013[J]. Environmental Pollution, 2017, 220: 168-177. doi: 10.1016/j.envpol.2016.09.036

[34]

GLEASON J A, POST G B, FAGLIANO J A. Associations of perfluorinated chemical serum concentrations and biomarkers of liver function and uric acid in the US population (NHANES), 2007-2010[J]. Environmental Research, 2015, 136: 8-14. doi: 10.1016/j.envres.2014.10.004

[35]

AKER A, AYOTTE P, CARON-BEAUDOIN E, et al. Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada[J]. Chemosphere, 2023, 310: 136797. doi: 10.1016/j.chemosphere.2022.136797

[36]

FU J J, GAO Y, CUI L, et al. Occurrence, temporal trends, and half-lives of perfluoroalkyl acids (PFAAs) in occupational workers in China[J]. Scientific Reports, 2016, 6: 38039. doi: 10.1038/srep38039

[37]

GEBBINK W A, van LEEUWEN S P J. Environmental contamination and human exposure to PFASs near a fluorochemical production plant: Review of historic and current PFOA and GenX contamination in the Netherlands[J]. Environment International, 2020, 137: 105583. doi: 10.1016/j.envint.2020.105583

[38]

YEUNG L W Y, SO M K, JIANG G B, et al. Perfluorooctanesulfonate and related fluorochemicals in human blood samples from China[J]. Environmental Science & Technology, 2006, 40(3): 715-720.

[39]

HARADA K, SAITO N, INOUE K, et al. The influence of time, sex and geographic factors on levels of perfluorooctane sulfonate and perfluorooctanoate in human serum over the last 25 years[J]. Journal of Occupational Health, 2004, 46(2): 141-147. doi: 10.1539/joh.46.141

[40]

ERICSON I, GÓMEZ M, NADAL M, et al. Perfluorinated chemicals in blood of residents in Catalonia (Spain) in relation to age and gender: A pilot study[J]. Environment International, 2007, 33(5): 616-623. doi: 10.1016/j.envint.2007.01.003

[41]

VASSILIADOU I, COSTOPOULOU D, FERDERIGOU A, et al. Levels of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) in blood samples from different groups of adults living in Greece[J]. Chemosphere, 2010, 80(10): 1199-1206. doi: 10.1016/j.chemosphere.2010.06.014

[42]

INGELIDO A M, MARRA V, ABBALLE A, et al. Perfluorooctanesulfonate and perfluorooctanoic acid exposures of the Italian general population[J]. Chemosphere, 2010, 80(10): 1125-1130. doi: 10.1016/j.chemosphere.2010.06.025

[43]

KÄRRMAN A, van BAVEL B, JÄRNBERG U, et al. Perfluorinated chemicals in relation to other persistent organic pollutants in human blood[J]. Chemosphere, 2006, 64(9): 1582-1591. doi: 10.1016/j.chemosphere.2005.11.040

[44]

LIU J Y, LI J G, LUAN Y, et al. Geographical distribution of perfluorinated compounds in human blood from Liaoning Province, China[J]. Environmental Science & Technology, 2009, 43(11): 4044-4048.

[45]

NILSSON H, KÄRRMAN A, WESTBERG H, et al. A time trend study of significantly elevated perfluorocarboxylate levels in humans after using fluorinated ski wax[J]. Environmental Science & Technology, 2010, 44(6): 2150-2155.

[46]

HARTMANN C, JAMNIK T, WEISS S, et al. Results of the Austrian Children’s Biomonitoring Survey 2020 part A: Per- and polyfluorinated alkylated substances, bisphenols, parabens and other xenobiotics[J]. International Journal of Hygiene and Environmental Health, 2023, 249: 114123. doi: 10.1016/j.ijheh.2023.114123

[47]

郭斐斐, 王雨昕, 李敬光, 等. 超高效液相色谱-串联质谱法测定人尿液中全氟有机化合物[J]. 色谱, 2011, 29(2): 126-130. doi: 10.3724/SP.J.1123.2011.00126 GUO F F, WANG Y X, LI J G, et al. Determination of perfluorinated compounds in human urine by ultra high performance liquid chromatographytandem mass spectrometry[J]. Chinese Journal of Chromatography, 2011, 29(2): 126-130 (in Chinese). doi: 10.3724/SP.J.1123.2011.00126

[48]

LI N, YING G G, HONG H C, et al. Perfluoroalkyl substances in the urine and hair of preschool children, airborne particles in kindergartens, and drinking water in Hongkong[J]. Environmental Pollution, 2021, 270: 116219. doi: 10.1016/j.envpol.2020.116219

[49]

ZHANG T, SUN H W, QIN X L, et al. PFOS and PFOA in paired urine and blood from general adults and pregnant women: Assessment of urinary elimination[J]. Environmental Science and Pollution Research, 2015, 22(7): 5572-5579. doi: 10.1007/s11356-014-3725-7

[50]

JI K, KIM S, KHO Y, et al. Serum concentrations of major perfluorinated compounds among the general population in Korea: Dietary sources and potential impact on thyroid hormones[J]. Environment International, 2012, 45: 78-85. doi: 10.1016/j.envint.2012.03.007

[51]

ZHANG Y F, BEESOON S, ZHU L Y, et al. Biomonitoring of perfluoroalkyl acids in human urine and estimates of biological half-life[J]. Environmental Science & Technology, 2013, 47(18): 10619-10627.

[52]

PEREZ F, LLORCA M, FARRÉ M, et al. Automated analysis of perfluorinated compounds in human hair and urine samples by turbulent flow chromatography coupled to tandem mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2012, 402(7): 2369-2378. doi: 10.1007/s00216-011-5660-5

[53]

KIM D H, LEE M Y, OH J E. Perfluorinated compounds in serum and urine samples from children aged 5-13 years in South Korea[J]. Environmental Pollution, 2014, 192: 171-178. doi: 10.1016/j.envpol.2014.05.024

[54]

刘嘉颖. 我国居民典型全氟有机化合物人体暴露水平与暴露途径研究[D]. 北京: 中国疾病预防控制中心, 2009. LIU J Y. Study on exposure level and exposure route of typical perfluoroorganic compounds in Chinese residents[D]. Beijing: Chinese Center For Disease Control And Prevention, 2009 (in Chinese).

[55]

HAN F, WANG Y X, LI J G, et al. Occurrences of legacy and emerging per- and polyfluoroalkyl substances in human milk in China: Results of the third National Human Milk Survey (2017-2020)[J]. Journal of Hazardous Materials, 2023, 443: 130163. doi: 10.1016/j.jhazmat.2022.130163

[56]

JIN H B, MAO L L, XIE J H, et al. Poly- and perfluoroalkyl substance concentrations in human breast milk and their associations with postnatal infant growth[J]. Science of the Total Environment, 2020, 713: 136417. doi: 10.1016/j.scitotenv.2019.136417

[57]

von EHRENSTEIN O S, FENTON S E, KATO K, et al. Polyfluoroalkyl chemicals in the serum and milk of breastfeeding women[J]. Reproductive Toxicology, 2009, 27(3/4): 239-245.

[58]

ZHENG G M, SCHREDER E, DEMPSEY J C, et al. Per- and polyfluoroalkyl substances (PFAS) in breast milk: Concerning trends for current-use PFAS[J]. Environmental Science & Technology, 2021, 55(11): 7510-7520.

[59]

KANG H, CHOI K, LEE H S, et al. Elevated levels of short carbon-chain PFCAs in breast milk among Korean women: Current status and potential challenges[J]. Environmental Research, 2016, 148: 351-359. doi: 10.1016/j.envres.2016.04.017

[60]

TAO L, MA J, KUNISUE T, et al. Perfluorinated compounds in human breast milk from several Asian countries, and in infant formula and dairy milk from the United States[J]. Environmental Science & Technology, 2008, 42(22): 8597-8602.

[61]

TYSMAN M, TOPPARI J, MAIN K M, et al. Levels of persistent organic pollutants in breast milk samples representing Finnish and Danish boys with and without hypospadias[J]. Chemosphere, 2023, 313: 137343. doi: 10.1016/j.chemosphere.2022.137343

[62]

夏慧. 全氟化合物的暴露风险及其与人体功能蛋白相互作用的研究[D]. 上海: 上海交通大学, 2018. XIA H. Study on the exposure risk of perfluorochemicals and their interaction with human functional proteins[D]. Shanghai: Shanghai Jiao Tong University, 2018 (in Chinese).

[63]

LIU J Y, LI J G, ZHAO Y F, et al. The occurrence of perfluorinated alkyl compounds in human milk from different regions of China[J]. Environment International, 2010, 36(5): 433-438. doi: 10.1016/j.envint.2010.03.004

[64]

WHITWORTH K W, HAUG L S, BAIRD D D, et al. Perfluorinated compounds and subfecundity in pregnant women[J]. Epidemiology, 2012, 23(2): 257-263. doi: 10.1097/EDE.0b013e31823b5031

[65]

ASHRAP P, WATKINS D J, CALAFAT A M, et al. Elevated concentrations of urinary triclocarban, phenol and paraben among pregnant women in Northern Puerto Rico: Predictors and trends[J]. Environment International, 2018, 121: 990-1002. doi: 10.1016/j.envint.2018.08.020

[66]

RAZA N, KIM K H, ABDULLAH M, et al. Recent developments in analytical quantitation approaches for parabens in human-associated samples[J]. TrAC Trends in Analytical Chemistry, 2018, 98: 161-173. doi: 10.1016/j.trac.2017.11.009

[67]

BROCKMAN J D, ROBERTSON J D, MORRIS J S, et al. Nail as a biomarker of selenium and methyl mercury in a rat model[J]. Journal of Radioanalytical and Nuclear Chemistry, 2008, 276(1): 59-64. doi: 10.1007/s10967-007-0410-z

[68]

JIAN J M, GUO Y, ZENG L X, et al. Global distribution of perfluorochemicals (PFCs) in potential human exposure source-a review[J]. Environment International, 2017, 108: 51-62. doi: 10.1016/j.envint.2017.07.024

[69]

高倍. 头发指甲作为人类全氟化合物暴露评价指示物的研究[D]. 大连: 大连理工大学, 2014. GAO B. Study on hair nails as indicators for evaluating the exposure of human perfluorinated compounds[D]. Dalian: Dalian University of Technology, 2014 (in Chinese).

[70]

WANG Y, SHI Y L, VESTERGREN R, et al. Using hair, nail and urine samples for human exposure assessment of legacy and emerging per- and polyfluoroalkyl substances[J]. Science of the Total Environment, 2018, 636: 383-391. doi: 10.1016/j.scitotenv.2018.04.279

[71]

姚丹, 张鸿, 柴之芳, 等. 天津成人头发指甲中有机氟污染物的残留特征[J]. 环境科学, 2013, 34(2): 718-723. YAO D, ZHANG H, CHAI Z F, et al. Residue of organic fluorine pollutants in hair and nails collected from Tianjin[J]. Environmental Science, 2013, 34(2): 718-723 (in Chinese).

[72]

MARTIN J W, MABURY S A, SOLOMON K R, et al. Dietary accumulation of perfluorinated acids in juvenile rainbow trout (Oncorhynchus mykiss)[J]. Environmental Toxicology and Chemistry, 2003, 22(1): 189-195. doi: 10.1002/etc.5620220125

[73]

LI J G, GUO F F, WANG Y X, et al. Development of extraction methods for the analysis of perfluorinated compounds in human hair and nail by high performance liquid chromatography tandem mass spectrometry[J]. Journal of Chromatography A, 2012, 1219: 54-60. doi: 10.1016/j.chroma.2011.11.015

[74]

CLAESSENS J, PIRARD C, CHARLIER C. Determination of contamination levels for multiple endocrine disruptors in hair from a non-occupationally exposed population living in Liege (Belgium)[J]. Science of the Total Environment, 2022, 815: 152734. doi: 10.1016/j.scitotenv.2021.152734

[75]

ALVES A, JACOBS G, VANERMEN G, et al. New approach for assessing human perfluoroalkyl exposure via hair[J]. Talanta, 2015, 144: 574-583. doi: 10.1016/j.talanta.2015.07.009

[76]

HENDERSON G L. Mechanisms of drug incorporation into hair[J]. Forensic Science International, 1993, 63(1/2/3): 19-29.

[77]

LI J G, GUO F F, WANG Y X, et al. Can nail, hair and urine be used for biomonitoring of human exposure to perfluorooctane sulfonate and perfluorooctanoic acid?[J]. Environment International, 2013, 53: 47-52. doi: 10.1016/j.envint.2012.12.002

[78]

ZHANG H, CHAI Z F, SUN H B. Human hair as a potential biomonitor for assessing persistent organic pollutants[J]. Environment International, 2007, 33(5): 685-693. doi: 10.1016/j.envint.2007.02.003

[79]

LIU W, XU L, LI X A, et al. Human nails analysis as biomarker of exposure to perfluoroalkyl compounds[J]. Environmental Science & Technology, 2011, 45(19): 8144-8150.

[80]

HINES E P, MENDOLA P, von EHRENSTEIN O S, et al. Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women[J]. Reproductive Toxicology, 2015, 54: 120-128. doi: 10.1016/j.reprotox.2014.11.006

[81]

徐森昊. 基于HPLC-MS/MS人头发中全氟化合物检测方法的建立及应用[D]. 沈阳: 中国医科大学, 2022. XU S H. Establishment and application of detection method of perfluorochemicals in human hair based on HPLC-MS/MS[D]. Shenyang: China Medical University, 2022 (in Chinese).

[82]

MARTÍN J, SANTOS J L, APARICIO I, et al. Exposure assessment to parabens, bisphenol A and perfluoroalkyl compounds in children, women and men by hair analysis[J]. Science of the Total Environment, 2019, 695: 133864. doi: 10.1016/j.scitotenv.2019.133864

[83]

LEE C, KIM C H, KIM S, et al. Simultaneous determination of bisphenol A and estrogens in hair samples by liquid chromatography-electrospray tandem mass spectrometry[J]. Journal of Chromatography B, 2017, 1058: 8-13. doi: 10.1016/j.jchromb.2017.05.007

[84]

SUNDERLAND E M, HU X C, DASSUNCAO C, et al. A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects[J]. Journal of Exposure Science & Environmental Epidemiology, 2019, 29(2): 131-147.

[85]

OLSEN G W, BURRIS J M, EHRESMAN D J, et al. Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers[J]. Environmental Health Perspectives, 2007, 115(9): 1298-1305. doi: 10.1289/ehp.10009

[86]

COSTA G, SARTORI S, CONSONNI D. Thirty years of medical surveillance in perfluooctanoic acid production workers[J]. Journal of Occupational and Environmental Medicine, 2009, 51(3): 364-372. doi: 10.1097/JOM.0b013e3181965d80

[87]

TROWBRIDGE J, GERONA R R, LIN T, et al. Exposure to perfluoroalkyl substances in a cohort of women firefighters and office workers in San francisco[J]. Environmental Science & Technology, 2020, 54(6): 3363-3374.

[88]

NAILA K, DUCATMAN ALAN M, SHRIPAD S, et al. Per- and polyfluoroalkyl substance and cardio metabolic markers in firefighters[J]. Journal of Occupational and Environmental Medicine, 2020, 62(12): 1076-1081. doi: 10.1097/JOM.0000000000002062

[89]

LEARY D B, TAKAZAWA M, KANNAN K, et al. Perfluoroalkyl substances and metabolic syndrome in firefighters: A pilot study[J]. Journal of Occupational and Environmental Medicine, 2020, 62(1): 52-57. doi: 10.1097/JOM.0000000000001756

[90]

ENGELSMAN M, TOMS L M L, BANKS A P W, et al. Biomonitoring in firefighters for volatile organic compounds, semivolatile organic compounds, persistent organic pollutants, and metals: A systematic review[J]. Environmental Research, 2020, 188: 109562. doi: 10.1016/j.envres.2020.109562

[91]

RUSSELL M H, HIMMELSTEIN M W, BUCK R C. Inhalation and oral toxicokinetics of 6: 2 FTOH and its metabolites in mammals[J]. Chemosphere, 2015, 120: 328-335. doi: 10.1016/j.chemosphere.2014.07.092

[92]

SHI Y L, VESTERGREN R, XU L, et al. Human exposure and elimination kinetics of chlorinated polyfluoroalkyl ether sulfonic acids (Cl-PFESAs)[J]. Environmental Science & Technology, 2016, 50(5): 2396-2404.

[93]

OLSEN G W, CHURCH T R, MILLER J P, et al. Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors[J]. Environmental Health Perspectives, 2003, 111(16): 1892-1901. doi: 10.1289/ehp.6316

[94]

CALAFAT A M, NEEDHAM L L, KUKLENYIK Z, et al. Perfluorinated chemicals in selected residents of the American continent[J]. Chemosphere, 2006, 63(3): 490-496. doi: 10.1016/j.chemosphere.2005.08.028

[95]

KÄRRMAN A, ERICSON I, van BAVEL B, et al. Exposure of perfluorinated chemicals through lactation: Levels of matched human milk and serum and a temporal trend, 1996–2004, in Sweden[J]. Environmental Health Perspectives, 2007, 115(2): 226-230. doi: 10.1289/ehp.9491

[96]

WONG F, MacLEOD M, MUELLER J F, et al. Enhanced elimination of perfluorooctane sulfonic acid by menstruating women: Evidence from population-based pharmacokinetic modeling[J]. Environmental Science & Technology, 2014, 48(15): 8807-8814.

[97]

KIM H Y, KIM S K, KANG D M, et al. The relationships between sixteen perfluorinated compound concentrations in blood serum and food, and other parameters, in the general population of South Korea with proportionate stratified sampling method[J]. Science of the Total Environment, 2014, 470/471: 1390-1400. doi: 10.1016/j.scitotenv.2013.06.039

[98]

CHO C R, LAM N H, CHO B M, et al. Concentration and correlations of perfluoroalkyl substances in whole blood among subjects from three different geographical areas in Korea[J]. Science of the Total Environment, 2015, 512/513: 397-405. doi: 10.1016/j.scitotenv.2015.01.070

[99]

HAUG L S, THOMSEN C, BRANTSÆTER A L, et al. Diet and particularly seafood are major sources of perfluorinated compounds in humans[J]. Environment International, 2010, 36(7): 772-778. doi: 10.1016/j.envint.2010.05.016

[100]

FU Y N, WANG T Y, WANG P, et al. Effects of age, gender and region on serum concentrations of perfluorinated compounds in general population of Henan, China[J]. Chemosphere, 2014, 110: 104-110. doi: 10.1016/j.chemosphere.2014.02.020

[101]

HARADA K H, YANG H R, MOON C S, et al. Levels of perfluorooctane sulfonate and perfluorooctanoic acid in female serum samples from Japan in 2008, Korea in 1994-2008 and Vietnam in 2007-2008[J]. Chemosphere, 2010, 79(3): 314-319. doi: 10.1016/j.chemosphere.2010.01.027

[102]

GULKOWSKA A, JIANG Q T, SO M K, et al. Persistent perfluorinated acids in seafood collected from two cities of China[J]. Environmental Science & Technology, 2006, 40(12): 3736-3741.

[103]

LI Y, FLETCHER T, MUCS D, et al. Half-lives of PFOS, PFH_xS and PFOA after end of exposure to contaminated drinking water[J]. Occupational and Environmental Medicine, 2018, 75(1): 46-51. doi: 10.1136/oemed-2017-104651

[104]

XU Y Y, FLETCHER T, PINEDA D, et al. Serum half-lives for short- and long-chain perfluoroalkyl acids after ceasing exposure from drinking water contaminated by firefighting foam[J]. Environmental Health Perspectives, 2020, 128(7): 77004. doi: 10.1289/EHP6785

[105]

HAN X, NABB D L, RUSSELL M H, et al. Renal elimination of perfluorocarboxylates (PFCAs)[J]. Chemical Research in Toxicology, 2012, 25(1): 35-46. doi: 10.1021/tx200363w

[106]

KIM S K, LEE K T, KANG C S, et al. Distribution of perfluorochemicals between sera and milk from the same mothers and implications for prenatal and postnatal exposures[J]. Environmental Pollution, 2011, 159(1): 169-174. doi: 10.1016/j.envpol.2010.09.008

[107]

KIM D H, LEE J H, OH J E. Perfluoroalkyl acids in paired serum, urine, and hair samples: Correlations with demographic factors and dietary habits[J]. Environmental Pollution, 2019, 248: 175-182. doi: 10.1016/j.envpol.2019.02.017

[108]

HAN F, LIU J Y, WANG Y X, et al. Penetration of perfluorooctanesulfonate isomers and their alternatives from maternal blood to milk and its associations with chemical properties and milk primary components[J]. Environmental Science & Technology, 2023, 57(6): 2457-2463.