磷酸三丁酯的生物毒性效应研究进展
Research Progress on Biological Toxicity Effects of Tributyl Phosphate
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摘要: 作为传统溴代阻燃剂的替代品，有机磷酸酯阻燃剂（organophosphate flame retardants，OPFRs）已广泛用于制造业，对环境造成的影响备受人们关注，成为新有机污染物的研究热点之一。目前，烷基OPFRs在各种环境介质中被频繁检出，通过吸入、饮食摄入或皮肤接触等途径进入生物体内，产生一定的毒性效应，对生态系统和人类健康具有潜在的风险。本文总结了一类烷基OPFR——磷酸三丁酯（tributyl phosphate，TBP）在生物体内的富集、毒性效应和作用机制，提出了当前研究中存在的问题和建议，同时展望了生物毒性评价的发展趋势，为今后全面评估TBP的生态风险提供依据。Abstract: Organophosphate flame retardants (OPFRs), as alternatives to conventional brominated flamed retardants, have been widely used in the manufacturing industry. Their impact on the environment has raised public concern and become a research hotspot in the field of new organic pollutants. Currently, alkyl OPFRs have been detected frequently in various environmental media, leading to their accumulation in organisms through inhalation, dietary intake, or dermal contact, and consequent toxic effects on organisms. Therefore, alkyl OPFRs have potential risks on ecosystem and human health. In this review, we summarized the bioaccumulation in organisms, toxicity, and mechanisms of tributyl phosphate (TBP), an alkyl OPFR. We also raised some issues and made some suggestions in this research field, and prospected the development trend of biological toxicity assessment. Our work provides a potential means by which the ecological risk of TBP will be evaluated systematically in the future.
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Greaves A K, Letcher R J. A review of organophosphate esters in the environment from biological effects to distribution and fate[J]. Bulletin of Environmental Contamination and Toxicology, 2017, 98(1):2-7 van der Veen I, de Boer J. Phosphorus flame retardants:Properties, production, environmental occurrence, toxicity and analysis[J]. Chemosphere, 2012, 88(10):1119-1153 Iqbal M, Syed J H, Breivik K, et al. E-waste driven pollution in Pakistan:The first evidence of environmental and human exposure to flame retardants (FRs) in Karachi City[J]. Environmental Science & Technology, 2017, 51(23):13895-13905 Yan W, Hou M M, Zhang Q N, et al. Organophosphorus flame retardants and plasticizers in building and decoration materials and their potential burdens in newly decorated houses in China[J]. Environmental Science & Technology, 2017, 51(19):10991-10999 Wang X, Zhu Q Q, Yan X T, et al. A review of organophosphate flame retardants and plasticizers in the environment:Analysis, occurrence and risk assessment[J]. The Science of the Total Environment, 2020, 731:139071-139095 Li H, Su G Y, Zou M, et al. Effects of tris(1,3-dichloro-2-propyl) phosphate on growth, reproduction, and gene transcription of Daphnia magna at environmentally relevant concentrations[J]. Environmental Science & Technology, 2015, 49(21):12975-12983 Bradley M, Rutkiewicz J, Mittal K, et al. In ovo exposure to organophosphorous flame retardants:Survival, development, neurochemical, and behavioral changes in white leghorn chickens[J]. Neurotoxicology and Teratology, 2015, 52:228-235 杜仲坤. 常用有机磷酸酯阻燃剂对斑马鱼发育及肝脏代谢的影响[D]. 南京:南京大学, 2016:28-29, 70 Du Z K. Effects of organophosphate flame retardants on zebrafish embryo development and liver metabolism[D]. Nanjing:Nanjing University, 2016 :28-29, 70(in Chinese)
赵海娟, 张文洁, 郑美玲, 等. GC-MS法测定烟用包装材料中非邻苯酯类增塑剂[J]. 包装工程, 2019, 40(9):59-65 Zhao H J, Zhang W J, Zheng M L, et al. Determination of non-phenyl ester plasticizers in packaging materials for cigarettes by GC-MS[J]. Packaging Engineering, 2019, 40(9):59-65(in Chinese)
韩福芹, 林铁华, 张春涛, 等. CMC聚合物对水泥砂浆力学性能的影响[J]. 建筑科学, 2015, 31(1):70-74 Han F Q, Lin T H, Zhang C T, et al. Effects of CMC polymer on mechanical properties of cement mortars[J]. Building Science, 2015, 31(1):70-74(in Chinese)
田庆华, 洪建邦, 辛云涛, 等. 高酸复杂含锑溶液中锑的萃取回收工艺[J]. 中国有色金属学报, 2019, 29(6):1268-1278 Tian Q H, Hong J B, Xin Y T, et al. Recover process of antimony from antimony-bearing complex solution with high acidity by extraction[J]. The Chinese Journal of Nonferrous Metals, 2019, 29(6):1268-1278(in Chinese)
Marklund A, Andersson B, Haglund P. Traffic as a source of organophosphorus flame retardants and plasticizers in snow[J]. Environmental Science & Technology, 2005, 39(10):3555-3562 Li J, Xie Z Y, Mi W Y, et al. Organophosphate esters in air, snow, and seawater in the north Atlantic and the Arctic[J]. Environmental Science & Technology, 2017, 51(12):6887-6896 He J H, Li J F, Ma L Y, et al. Large-scale distribution of organophosphate esters (flame retardants and plasticizers) in soil from residential area across China:Implications for current level[J]. Science of the Total Environment, 2019, 697:133997 邓旭, 印红玲, 何婉玲, 等. 有机磷酸酯在成都市市/郊区剖面土壤及农作物中的分布及迁移[J]. 环境化学, 2019, 38(3):679-685 Deng X, Yin H L, He W L, et al. Distribution and migration of OPEs in soil profile and crops in urban and suburban areas of Chengdu[J]. Environmental Chemistry, 2019, 38(3):679-685(in Chinese)
Hou L, Jiang J Y, Gan Z W, et al. Spatial distribution of organophosphorus and brominated flame retardants in surface water, sediment, groundwater, and wild fish in Chengdu, China[J]. Archives of Environmental Contamination and Toxicology, 2019, 77(2):279-290 Luo Q, Shan Y, Muhammad A, et al. Levels, distribution, and sources of organophosphate flame retardants and plasticizers in urban soils of Shenyang, China[J]. Environmental Science and Pollution Research International, 2018, 25(31):31752-31761 Li J, Yu N Y, Zhang B B, et al. Occurrence of organophosphate flame retardants in drinking water from China[J]. Water Research, 2014, 54:53-61 Rowling B, Kinsela A S, Comarmond M J, et al. Measurement of tributyl phosphate (TBP) in groundwater at a legacy radioactive waste site and its possible role in contaminant mobilisation[J]. Journal of Environmental Radioactivity, 2017, 178-179:377-384 Fries E, Püttmann W. Monitoring of the three organophosphate esters TBP, TCEP and TBEP in river water and ground water (Oder, Germany)[J]. Journal of Environmental Monitoring, 2003, 5(2):346-352 陈阳, 印红玲, 吴迪, 等. 海螺沟植物和积雪中有机磷酸酯的分布及来源[J]. 环境科学, 2019, 40(9):4295-4302 Chen Y, Yin H L, Wu D, et al. Distribution and sources of OPEs in plants and snow in Hailuogou[J]. Environmental Science, 2019, 40(9):4295-4302(in Chinese)
Wang D, Wang P, Wang Y W, et al. Temporal variations of PM2.5-bound organophosphate flame retardants in different microenvironments in Beijing, China, and implications for human exposure[J]. Science of the Total Environment, 2019, 666:226-234 Langer S, Fredricsson M, Weschler C J, et al. Organophosphate esters in dust samples collected from Danish homes and daycare centers[J]. Chemosphere, 2016, 154:559-566 Zhou L L, Hiltscher M, Gruber D, et al. Organophosphate flame retardants (OPFRs) in indoor and outdoor air in the Rhine/Main area, Germany:Comparison of concentrations and distribution profiles in different microenvironments[J]. Environmental Science and Pollution Research International, 2017, 24(12):10992-11005 Hou M M, Shi Y L, Na G S, et al. A review of organophosphate esters in indoor dust, air, hand wipes and silicone wristbands:Implications for human exposure[J]. Environment International, 2021, 146:106261-106281 丁锦建. 典型有机磷阻燃剂人体暴露途径与蓄积特征研究[D]. 杭州:浙江大学, 2016:81-118 Ding J J. Study on human exposure pathways and accumulation characteristics of typical organophosphate flame retardants[D]. Hangzhou:Zhejiang University, 2016:81 -118(in Chinese)
Liu Y E, Luo X J, Zapata Corella P, et al. Organophosphorus flame retardants in a typical freshwater food web:Bioaccumulation factors, tissue distribution, and trophic transfer[J]. Environmental Pollution, 2019, 255:113286 Trapp S, Eggen T. Simulation of the plant uptake of organophosphates and other emerging pollutants for greenhouse experiments and field conditions[J]. Environmental Science and Pollution Research International, 2013, 20(6):4018-4029 He M J, Lu J F, Wei S Q. Organophosphate esters in biota, water, and air from an agricultural area of Chongqing, Western China:Concentrations, composition profiles, partition and human exposure[J]. Environmental Pollution, 2019, 244:388-397 Eggen T, Heimstad E S, Stuanes A O, et al. Uptake and translocation of organophosphates and other emerging contaminants in food and forage crops[J]. Environmental Science and Pollution Research International, 2013, 20(7):4520-4531 张正恩. 南宁市水稻田环境中有机磷酸酯的污染特征及风险评价[D]. 沈阳:沈阳农业大学, 2020:34-46 Zhang Z G. Pollution characteristics and risk assessment of organophosphorus esters in paddy fields of Nanning City[D]. Shenyang:Shenyang Agricultural University, 2020:34 -46(in Chinese)
邓旭. OPEs在水生生物中的生物富集效应研究[D]. 成都:成都信息工程大学, 2019:20-46 Deng X. Bioaccumulation effect of OPEs in aquatic organisms[D]. Chengdu:Chengdu University of Information Technology, 2019:20 -46(in Chinese)
Ma Y Q, Cui K Y, Zeng F, et al. Microwave-assisted extraction combined with gel permeation chromatography and silica gel cleanup followed by gas chromatography-mass spectrometry for the determination of organophosphorus flame retardants and plasticizers in biological samples[J]. Analytica Chimica Acta, 2013, 786:47-53 Kim J W, Isobe T, Chang K H, et al. Levels and distribution of organophosphorus flame retardants and plasticizers in fishes from Manila Bay, the Philippines[J]. Environmental Pollution, 2011, 159(12):3653-3659 Yang Y, Liu P, Li M. Tri-n-butyl phosphate induced earthworm intestinal damage by influencing nutrient absorption and energy homeostasis of intestinal epithelial cells[J]. Journal of Hazardous Materials, 2020, 398:122850 Liu Y E, Luo X J, Guan K L, et al. Tissue-specific distribution of legacy and emerging organophosphorus flame retardants and plasticizers in frogs[J]. Toxics, 2021, 9(6):124-135 汪国威. 有机磷酸酯阻燃剂在鱼体内的富集、分布和代谢及其机制[D]. 南京:南京大学, 2017:43-63 Wang G W. Accumulation, distribution and transformation of organophosphate flame retardants in fish and their underlying mechanism[D]. Nanjing:Nanjing University, 2017:43 -63(in Chinese)
Hou R, Liu C, Gao X Z, et al. Accumulation and distribution of organophosphate flame retardants (PFRs) and their di-alkyl phosphates (DAPs) metabolites in different freshwater fish from locations around Beijing, China[J]. Environmental Pollution, 2017, 229:548-556 Hou R, Yuan S W, Feng C L, et al. Toxicokinetic patterns, metabolites formation and distribution in various tissues of the Chinese rare minnow (Gobiocypris rarus) exposed to tri(2-butoxyethyl) phosphate (TBOEP) and tri-n-butyl phosphate (TNBP)[J]. Science of the Total Environment, 2019, 668:806-814 Choo G, Cho H S, Park K, et al. Tissue-specific distribution and bioaccumulation potential of organophosphate flame retardants in crucian carp[J]. Environmental Pollution, 2018, 239:161-168 Li Z R, He C, Thai P, et al. Organophosphate esters and their specific metabolites in chicken eggs from across Australia:Occurrence, profile, and distribution between yolk and albumin fractions[J]. Environmental Pollution, 2020, 262:114260 Greaves A K, Letcher R J. Comparative body compartment composition and in ovo transfer of organophosphate flame retardants in North American Great Lakes herring gulls[J]. Environmental Science & Technology, 2014, 48(14):7942-7950 陈敏, 廖晓亮, 杨春, 等. 典型有机磷酸酯在小鼠组织内的特异性分布[J]. 环境化学, 2020, 39(10):2627-2636 Chen M, Liao X L, Yang C, et al. The tissue accumulation and distribution of typical organophosphate flame retardants (OPFRs) in mice[J]. Environmental Chemistry, 2020, 39(10):2627-2636(in Chinese)
Sundkvist A M, Olofsson U, Haglund P. Organophosphorus flame retardants and plasticizers in marine and fresh water biota and in human milk[J]. Journal of Environmental Monitoring, 2010, 12(4):943-951 徐勤勤. 汞和有机磷酸酯在三峡库区水、土/沉积物中的分布与鱼体富集特征[D]. 重庆:西南大学, 2019:49-79 Xu Q Q. Distribution characteristics of mercury and organophosphorus ester in water, soil/sediment and fish in the Three Gorges Reservoir[D]. Chongqing:Southwest University, 2019:49 -79(in Chinese)
Wang L, Huang X L, Laserna A K C, et al. Metabolism of tri-n-butyl phosphate in earthworm Perionyx excavatus[J]. Environmental Pollution, 2018, 234:389-395 李鹏, 李秋旭, 马玉龙, 等. 凝胶渗透色谱-固相萃取净化-气相色谱-质谱法测定人血清中磷酸三酯类化合物[J]. 分析化学, 2015, 43(7):1033-1039 Li P, Li Q X, Ma Y L, et al. Determination of organophosphate esters in human serum using gel permeation chromatograph and solid phase extraction coupled with GC-MS[J]. Chinese Journal of Analytical Chemistry, 2015, 43(7):1033-1039(in Chinese)
张晓华, 赵繁荣, 胡建英. 我国人群有机磷阻燃剂暴露评估及其健康风险[J]. 生态毒理学报, 2021, 16(3):155-165 Zhang X H, Zhao F R, Hu J Y. Exposure assessment and health risk of organophosphate flame retardants in general population in China[J]. Asian Journal of Ecotoxicology, 2021, 16(3):155-165(in Chinese)
Bai X Y, Lu S Y, Xie L, et al. A pilot study of metabolites of organophosphorus flame retardants in paired maternal urine and amniotic fluid samples:Potential exposure risks of tributyl phosphate to pregnant women[J]. Environmental Science Processes & Impacts, 2019, 21(1):124-132 Ding J J, Xu Z M, Huang W, et al. Organophosphate ester flame retardants and plasticizers in human placenta in Eastern China[J]. Science of the Total Environment, 2016, 554-555:211-217 Zhao F R, Wan Y, Zhao H Q, et al. Levels of blood organophosphorus flame retardants and association with changes in human sphingolipid homeostasis[J]. Environmental Science & Technology, 2016, 50(16):8896-8903 Ma Y L, Jin J, Li P, et al. Organophosphate ester flame retardant concentrations and distributions in serum from inhabitants of Shandong, China, and changes between 2011 and 2015[J]. Environmental Toxicology and Chemistry, 2017, 36(2):414-421 Gao D T, Yang J, Bekele T G, et al. Organophosphate esters in human serum in Bohai Bay, North China[J]. Environmental Science and Pollution Research International, 2020, 27(3):2721-2729 Dodson R E, van den Eede N, Covaci A, et al. Urinary biomonitoring of phosphate flame retardants:Levels in California adults and recommendations for future studies[J]. Environmental Science & Technology, 2014, 48(23):13625-13633 Zhang T, Bai X Y, Lu S Y, et al. Urinary metabolites of organophosphate flame retardants in China:Health risk from tris(2-chloroethyl) phosphate (TCEP) exposure[J]. Environment International, 2018, 121:1363-1371 Chen Y, Fang J Z, Ren L, et al. Urinary metabolites of organophosphate esters in children in South China:Concentrations, profiles and estimated daily intake[J]. Environmental Pollution, 2018, 235:358-364 Cequier E, Sakhi A K, Marcé R M, et al. Human exposure pathways to organophosphate triesters:A biomonitoring study of mother-child pairs[J]. Environment International, 2015, 75:159-165 Fromme H, Lahrz T, Kraft M, et al. Organophosphate flame retardants and plasticizers in the air and dust in German daycare centers and human biomonitoring in visiting children (LUPE 3)[J]. Environment International, 2014, 71:158-163 Lu S Y, Li Y X, Zhang T, et al. Effect of e-waste recycling on urinary metabolites of organophosphate flame retardants and plasticizers and their association with oxidative stress[J]. Environmental Science & Technology, 2017, 51(4):2427-2437 Zhao F R, Chen M, Gao F M, et al. Organophosphorus flame retardants in pregnant women and their transfer to chorionic villi[J]. Environmental Science & Technology, 2017, 51(11):6489-6497 Kim J W, Isobe T, Muto M, et al. Organophosphorus flame retardants (PFRs) in human breast milk from several Asian countries[J]. Chemosphere, 2014, 116:91-97 He C, Toms L M L, Thai P, et al. Urinary metabolites of organophosphate esters:Concentrations and age trends in Australian children[J]. Environment International, 2018, 111:124-130 李宗睿. 典型有机污染物在鸡生命发育早期阶段的代际传递与生物转化[D]. 北京:中国科学院大学, 2019:49-50 Li Z R. Maternal transfer and biotransformation of selected organic pollutants in early life stage of chicken[D]. Beijing:University of Chinese Academy of Sciences, 2019:49 -50(in Chinese)
Su G Y, Letcher R J, Yu H X. Organophosphate flame retardants and plasticizers in aqueous solution:pH-dependent hydrolysis, kinetics, and pathways[J]. Environmental Science & Technology, 2016, 50(15):8103-8111 Jiang X F, Yang Y, Liu P, et al. Transcriptomics and metabolomics reveal Ca2+ overload and osmotic imbalance-induced neurotoxicity in earthworms (Eisenia fetida) under tri-n-butyl phosphate exposure[J]. The Science of the Total Environment, 2020, 748:142169 Suzuki T, Sasaki K, Takeda M, et al. Metabolism of tributyl phosphate in male rats[J]. Journal of Agricultural and Food Chemistry, 1984, 32(3):603-610 Wang G W, Chen H Y, Du Z K, et al. In vivo metabolism of organophosphate flame retardants and distribution of their main metabolites in adult zebrafish[J]. Science of the Total Environment, 2017, 590-591:50-59 Hou R, Huang C, Rao K F, et al. Characterized in vitro metabolism kinetics of alkyl organophosphate esters in fish liver and intestinal microsomes[J]. Environmental Science & Technology, 2018, 52(5):3202-3210 Greaves A K, Su G Y, Letcher R J. Environmentally relevant organophosphate triesters in herring gulls:in vitro biotransformation and kinetics and diester metabolite formation using a hepatic microsomal assay[J]. Toxicology and Applied Pharmacology, 2016, 308:59-65 Mennillo E, Cappelli F, Arukwe A. Biotransformation and oxidative stress responses in rat hepatic cell-line (H4IIE) exposed to organophosphate esters (OPEs)[J]. Toxicology and Applied Pharmacology, 2019, 371:84-94 Sasaki K, Suzuki T, Takeda M, et al. Metabolism of phosphoric acid triesters by rat liver homogenate[J]. Bulletin of Environmental Contamination and Toxicology, 1984, 33(3):281-288 Berne C, Pignol D, Lavergne J, et al. CYP201A2, a cytochrome P450 from Rhodopseudomonas palustris, plays a key role in the biodegradation of tributyl phosphate[J]. Applied Microbiology and Biotechnology, 2007, 77(1):135-144 Neerathilingam M, Volk D E, Sarkar S, et al. 1H NMR-based metabonomic investigation of tributyl phosphate exposure in rats[J]. Toxicology Letters, 2010, 199(1):10-16 Saillenfait A M, Ndaw S, Robert A, et al. Recent biomonitoring reports on phosphate ester flame retardants:A short review[J]. Archives of Toxicology, 2018, 92(9):2749-2778 Auletta C S, Weiner M L, Richter W R. A dietary toxicity/oncogenicity study of tributyl phosphate in the rat[J]. Toxicology, 1998, 128(2):125-134 Brandsma S H, Leonards P E G, Leslie H A, et al. Tracing organophosphorus and brominated flame retardants and plasticizers in an estuarine food web[J]. Science of the Total Environment, 2015, 505:22-31 Sasaki K, Takeda M, Uchiyama M. Toxicity, absorption and elimination of phosphoric acid triesters by killifish and goldfish[J]. Bulletin of Environmental Contamination and Toxicology, 1981, 27(6):775-782 Pantelaki I, Voutsa D. Occurrence, analysis and risk assessment of organophosphate esters (OPEs) in biota:A review[J]. Marine Pollution Bulletin, 2020, 160:111547 徐怀洲, 王智志, 张圣虎, 等. 有机磷酸酯类阻燃剂毒性效应研究进展[J]. 生态毒理学报, 2018, 13(3):19-30 Xu H Z, Wang Z Z, Zhang S H, et al. Research progress on toxicity effects of organophosphate flame retardants[J]. Asian Journal of Ecotoxicology, 2018, 13(3):19-30(in Chinese)
姜丹, 周建国, 李娜, 等. 有机磷酸酯对青海弧菌Q67毒性的构效关系[J]. 生态毒理学报, 2014, 9(1):71-80 Jiang D, Zhou J G, Li N, et al. Quantitative structure-activity relationships between acute toxicity of organophosphates andVibrio qinghaiensis sp.-Q67[J]. Asian Journal of Ecotoxicology, 2014, 9(1):71-80(in Chinese)
Krivoshiev B V, Dardenne F, Blust R, et al. Elucidating toxicological mechanisms of current flame retardants using a bacterial gene profiling assay[J]. Toxicology in Vitro, 2015, 29(8):2124-2132 Chu Y H, Zhang C F, Ho S H. Computational simulation associated with biological effects of alkyl organophosphate flame retardants with different carbon chain lengths on Chlorella pyrenoidosa[J]. Chemosphere, 2021, 263:127997 Liu Q, Tang X X, Wang Y, et al. ROS changes are responsible for tributyl phosphate (TBP)-induced toxicity in the alga Phaeodactylum tricornutum[J]. Aquatic Toxicology, 2019, 208:168-178 Song H, Fan X J, Liu G F, et al. Inhibitory effects of tributyl phosphate on algal growth, photosynthesis, and fatty acid synthesis in the marine diatom Phaeodactylum tricornutum[J]. Environmental Science and Pollution Research International, 2016, 23(23):24009-24018 Zhang X, Tang X X, Yang Y Y, et al. Responses of the reproduction, population growth and metabolome of the marine rotifer Brachionus plicatilis to tributyl phosphate (TnBP)[J]. Environmental Pollution, 2021, 273:116462 Cristale J, García Vázquez A, Barata C, et al. Priority and emerging flame retardants in rivers:Occurrence in water and sediment, Daphnia magna toxicity and risk assessment[J]. Environment International, 2013, 59:232-243 杨扬. 有机磷酸酯(OPEs)对赤子爱胜蚓的毒性效应及机制研究[D]. 南京:南京大学, 2018:27-40 Yang Y. Ecotoxicity effect and mechanism of organophosphorus esters (OPEs) on earthworm Eisenia fetida[D]. Nanjing:Nanjing University, 2018:27 -40(in Chinese)
Healy C E, Beyrouty P C, Broxup B R. Acute and subchronic neurotoxicity studies with tri-n-butyl phosphate in adult Sprague-Dawley rats[J]. American Industrial Hygiene Association Journal, 1995, 56(4):349-355 Chang Y Q, Cui H Y, Jiang X F, et al. Comparative assessment of neurotoxicity impacts induced by alkyl tri-n-butyl phosphate and aromatic tricresyl phosphate in PC12 cells[J]. Environmental Toxicology, 2020, 35(12):1326-1333 An J, Hu J W, Shang Y, et al. The cytotoxicity of organophosphate flame retardants on HepG2, A549 and Caco-2 cells[J]. Journal of Environmental Science and Health Part A, Toxic/Hazardous Substances & Environmental Engineering, 2016, 51(11):980-988 Ren G F, Hu J W, Shang Y, et al. Tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) induced apoptosis and cell cycle arrest in HepG2 cells[J]. Toxicology Research, 2017, 6(6):902-911 American Conference of Government Industrial Hygienists (ACGIH). Threshold limit values and biological exposure indices for 1986-1987[R]. Cininnati, Ohio:ACGIH, 1986:654-658 彭涛. 有机磷酸酯阻燃剂对模式鱼的行为毒性[D]. 杭州:浙江工业大学, 2015:14-33 Peng T. Behavioral toxicolgy of organophosphorus flame retardants on the model fish[D]. Hangzhou:Zhejiang University of Technology, 2015:14 -33(in Chinese)
Müller W U, Streffer C, Markoski L. Does tributyl phosphate influence the radiation risk of a highly proliferating system:The early mouse embryo in vitro?[J]. Health Physics, 1987, 53(6):667-671 Tyl R W, Gerhart J M, Myers C B, et al. Two-generation reproductive toxicity study of dietary tributyl phosphate in CD rats[J]. Toxicological Sciences, 1997, 40(1):90-100 Noda T, Yamano T, Shimizu M, et al. Effects of tri-n-butyl phosphate on pregnancy in rats[J]. Food and Chemical Toxicology, 1994, 32(11):1031-1036 Laham S, Long G, Broxup B. Subacute oral toxicity of tri-n-butyl phosphate in the Sprague-Dawley rat[J]. Journal of Applied Toxicology, 1984, 4(3):150-154 Oishi H, Oishi S, Hiraga K. Toxicity of several phosphoric acid esters in rats[J]. Toxicology Letters, 1982, 13(1-2):29-34 Laham S, Broxup B, Long G. Induction of urinary bladder hyperplasia in Sprague-Dawley rats orally administered tri-n-butyl phosphate[J]. Archives of Environmental Health, 1985, 40(6):301-306 Oishi H, Oishi S, Hiraga K. Toxicity of tri-n-butyl phosphate, with special reference to organ weights, serum components and cholinesterase activity in male rats[J]. Toxicology Letters, 1980, 6(2):81-85 Salovsky P, Shopova V, Dancheva V. Antioxidant defense mechanisms in the lung toxicity of tri-n-butyl phosphate[J]. American Journal of Industrial Medicine, 1998, 33(1):11-15 Arnold L L, Christenson W R, Cano M, et al. Tributyl phosphate effects on urine and bladder epithelium in male Sprague-Dawley rats[J]. Fundamental and Applied Toxicology, 1997, 40(2):247-255 Auletta C S, Kotkoskie L A, Saulog T, et al. A dietary oncogenicity study of tributyl phosphate in the CD-1 mouse[J]. Toxicology, 1998, 128(2):135-141 董竞武, 叶于薇, 仲伟鉴, 等. 生物标志物用于有机磷农药的迟发性神经毒性研究[J]. 环境与职业医学, 2006, 23(1):41-44 , 47 Dong J W, Ye Y W, Zhong W J, et al. Acute delayed neurotoxicity study of organophosphorous pesticides by biomarker methods[J]. Journal of Environmental & Occupational Medicine, 2006, 23(1):41-44, 47(in Chinese)
彭涛, 王思思, 任琳, 等. 磷酸三苯酯对斑马鱼早期生命阶段的神经毒性研究[J]. 生态毒理学报, 2016, 11(1):254-260 Peng T, Wang S S, Ren L, et al. Neurotoxicity of triphenyl phosphate on the early life stages of zebrafish[J]. Asian Journal of Ecotoxicology, 2016, 11(1):254-260(in Chinese)
Hardos J E, Rubenstein M, Pfahler S, et al. Cholinesterase inhibition and exposure to organophosphate esters in aircraft maintenance workers[J]. Aerospace Medicine and Human Performance, 2020, 91(9):710-714 Sun L W, Xu W B, Peng T, et al. Developmental exposure of zebrafish larvae to organophosphate flame retardants causes neurotoxicity[J]. Neurotoxicology and Teratology, 2016, 55:16-22 Carrington C D, Lapadula D M, Othman M, et al. Assessment of the delayed neurotoxicity of tributyl phosphate, tributoxyethyl phosphate, and dibutylphenyl phosphate[J]. Toxicology and Industrial Health, 1990, 6(3-4):415-423 袁逢新, 李文华, 罗国琦, 等. 磷酸三丁酯致鸡脊髓神经元凋亡的试验研究[J]. 中国畜牧兽医, 2005, 32(10):54-56 Laham S, Szabo J, Long G. Effects of tri-n-butyl phosphate on the peripheral nervous system of the Sprague-Dawley rat[J]. Drug and Chemical Toxicology, 1983, 6(4):363-377 Zhang Q, Ji C Y, Yin X H, et al. Thyroid hormone-disrupting activity and ecological risk assessment of phosphorus-containing flame retardants by in vitro, in vivo and in silico approaches[J]. Environmental Pollution, 2016, 210:27-33 American Conference of Governmental Industrial Hygienists (ACGIH). TLVS and BEIS[R]. Cininnati:ACGIH, 2013:234-237 李龙, 耿晓, 韩茹, 等. 工作场所空气中磷酸三丁酯职业接触限值研究[J]. 中华劳动卫生职业病杂志, 2018, 36(8):600-603 Li L, Geng X, Han R, et al. Study on occupational exposure limits of tributyl phosphate in the workplace air[J]. Chinese Journal of Industrial Hygiene and Occupational Diseases, 2018, 36(8):600-603(in Chinese)
Araki A, Saito I, Kanazawa A, et al. Phosphorus flame retardants in indoor dust and their relation to asthma and allergies of inhabitants[J]. Indoor Air, 2014, 24(1):3-15 Yan S H, Wu H M, Qin J H, et al. Halogen-free organophosphorus flame retardants caused oxidative stress and multixenobiotic resistance in Asian freshwater clams (Corbicula fluminea)[J]. Environmental Pollution, 2017, 225:559-568 Kojima H, Takeuchi S, Itoh T, et al. In vitro endocrine disruption potential of organophosphate flame retardants via human nuclear receptors[J]. Toxicology, 2013, 314(1):76-83 Zheng B H, Lei K, Liu R Z, et al. Integrated biomarkers in wild crucian carp for early warning of water quality in Hun River, North China[J]. Journal of Environmental Sciences, 2014, 26(4):909-916 Gupta S C, Sharma A, Mishra M, et al. Heat shock proteins in toxicology:How close and how far?[J]. Life Sciences, 2010, 86(11-12):377-384 陈寒嫣. 常用有机磷酸酯阻燃剂对斑马鱼肝脏毒性研究[D]. 南京:南京大学, 2017:26-40 Chen H Y. Hepatotoxicity of commonly used organophosphate flame retardants in zebrafish (Danio rerio)[D]. Nanjing:Nanjing University, 2017:26 -40(in Chinese)
Zhou L L, Zhang W P, Xie W P, et al. Tributyl phosphate impairs the urea cycle and alters liver pathology and metabolism in mice after short-term exposure based on a metabonomics study[J]. Science of the Total Environment, 2017, 603-604:77-85 Krivoshiev B V, Dardenne F, Covaci A, et al. Assessing in-vitro estrogenic effects of currently-used flame retardants[J]. Toxicology in Vitro, 2016, 33:153-162 Kojima H, Takeuchi S, van den Eede N, et al. Effects of primary metabolites of organophosphate flame retardants on transcriptional activity via human nuclear receptors[J]. Toxicology Letters, 2016, 245:31-39 Yan S H, Wang Q, Yang L H, et al. Comparison of the toxicity effects of tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with tributyl phosphate (TNBP) reveals the mechanism of the apoptosis pathway in Asian freshwater clams (Corbicula fluminea)[J]. Environmental Science & Technology, 2020, 54(11):6850-6858 Forman H J, Fukuto J M, Torres M. Redox signaling:Thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers[J]. American Journal of Physiology Cell Physiology, 2004, 287(2):C246-C256 Verbruggen E J, Rila J R, Traas T T, et al. Environmental risk limits for several phosphate esters, with possible application as flame retardant[R]. Bilthoven:National Institute for Public Health and the Environment (RIVM), 2006 蒋义国. miRNA、lncRNA与circRNA三者间相互调控与化学物毒性作用[C]//中国毒理学会. 第七次全国毒理学大会暨第八届湖北科技论坛论文集. 武汉:中国毒理学会, 2015:309 -
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