微塑料和纳米塑料对胃肠道及肝脏的毒性效应机制研究进展
Mechanism of Toxic Effects of Microplastics and Nano-plastics on Gastrointestinal Tract and Liver: A Review
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摘要: 由于塑料制品的大量生产和使用,其废弃物降解产生的微塑料(microplastics, MPs)作为一种新型的环境污染物近年来逐渐引起全世界的关注。持续的老化会使微塑料降解为纳米塑料(nano-plastics, NPs),在进入人体后增加对细胞的危害,因此微塑料和纳米塑料对人体产生的毒性效应及健康危害也日益成为环境领域的研究热点。本文基于已有研究,重点阐述了人体内微塑料和纳米塑料沉积对胃肠道产生氧化应激、炎症及细胞凋亡相关毒性效应的机制,以及造成肝脏糖脂代谢紊乱的潜在机制,为进一步开展微塑料和纳米塑料的毒性效应机制研究和人体健康风险评估提供理论依据。Abstract: In recent years, due to the mass production and use of plastic products, microplastics (MPs) produced by the degradation of their wastes have gradually attracted the world's attention as a new type of environmental pollutant. Continuous aging degrades MPs into nano-plastics (NPs), which can increase their damage to cells when they enter the human body. Therefore, the toxic effects and health hazards of MPs and NPs on the human body have increasingly become a research hotspot in the environmental field. Based on existing studies, this article focuses on the mechanism related to the toxic effects of MPs and NPs deposition on the gastrointestinal tract (e.g., oxidative stress, inflammation and apoptosis), and the potential mechanism of glucose and lipid metabolism disorders in the liver. This study provides a theoretical basis for further research on the mechanism of toxic effects of MPs and NPs and human health risk assessment.
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Key words:
- microplastics /
- gastrointestinal tract /
- glucolipid metabolism /
- liver /
- oxidative stress /
- nano-plastics
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Turner A, Holmes L, Thompson R C, et al. Metals and marine microplastics:Adsorption from the environment versus addition during manufacture, exemplified with lead[J]. Water Research, 2020, 173:115577 Kazour M, Terki S, Rabhi K, et al. Sources of microplastics pollution in the marine environment:Importance of wastewater treatment plant and coastal landfill[J]. Marine Pollution Bulletin, 2019, 146:608-618 Lambert S, Wagner M.Characterisation of nanoplastics during the degradation of polystyrene[J]. Chemosphere, 2016, 145:265-268 钱亚茹, 石磊磊, 沈茜, 等. 淡水环境中微塑料污染及毒性效应研究进展[J]. 环境工程技术学报, 2022, 12(4):1096-1104 Qian Y R, Shi L L, Shen Q, et al. Research progress on pollution and toxic effects of microplastics in freshwater environment[J]. Journal of Environmental Engineering Technology, 2022, 12(4):1096-1104(in Chinese)
李娇, 陈大岭, 陈玉立, 等. 微纳米塑料的人体健康风险研究进展[J]. 生态毒理学报, 2023, 18(2):175-187 Li J, Chen D L, Chen Y L, et al. Effects of micro/nano plastics on human health:A review[J]. Asian Journal of Ecotoxicology, 2023, 18(2):175-187(in Chinese)
Alimba C G, Faggio C. Microplastics in the marine environment:Current trends in environmental pollution and mechanisms of toxicological profile[J]. Environmental Toxicology and Pharmacology, 2019, 68:61-74 Schwabl P, Köppel S, Königshofer P, et al. Detection of various microplastics in human stool:A prospective case series[J]. Annals of Internal Medicine, 2019, 171(7):453-457 Amereh F, Amjadi N, Mohseni-Bandpei A, et al. Placental plastics in young women from general population correlate with reduced foetal growth in IUGR pregnancies[J]. Environmental Pollution, 2022, 314:120174 Leslie H A, van Velzen M J M, Brandsma S H, et al. Discovery and quantification of plastic particle pollution in human blood[J]. Environment International, 2022, 163:107199 刘雅宣, 王兰, 师庆英, 等. 微塑料的人体暴露和健康风险研究进展[J]. 生态毒理学报, 2022, 17(3):354-365 Liu Y X, Wang L, Shi Q Y, et al. Research progress on human exposure and health risks of microplastics[J]. Asian Journal of Ecotoxicology, 2022, 17(3):354-365(in Chinese)
Vethaak A D, Legler J. Microplastics and human health[J]. Science, 2021, 371(6530):672-674 Tong X H, Li B Q, Li J, et al. Polyethylene microplastics cooperate with Helicobacter pylori to promote gastric injury and inflammation in mice[J]. Chemosphere, 2022, 288(Pt 2):132579 Luo T, Wang C Y, Pan Z H, et al. Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring[J]. Environmental Science & Technology, 2019, 53(18):10978-10992 Wang L X, Wang Y X, Xu M, et al. Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid[J]. Journal of Hazardous Materials, 2021, 410:124536 Yee M S L, Hii L W, Looi C K, et al. Impact of microplastics and nanoplastics on human health[J]. Nanomaterials, 2021, 11(2):496 Hesler M, Aengenheister L, Ellinger B, et al. Multi-endpoint toxicological assessment of polystyrene nano- and microparticles in different biological models in vitro[J]. Toxicology in Vitro:An International Journal Published in Association with BIBRA, 2019, 61:104610 Cortés C, Domenech J, Salazar M, et al. Nanoplastics as a potential environmental health factor:Effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells[J]. Environmental Science:Nano, 2020, 7(1):272-285 Dong X S, Liu X B, Hou Q L, et al. From natural environment to animal tissues:A review of microplastics(nanoplastics) translocation and hazards studies[J]. The Science of the Total Environment, 2023, 855:158686 Campanale C, Massarelli C, Savino I, et al. A detailed review study on potential effects of microplastics and additives of concern on human health[J]. International Journal of Environmental Research and Public Health, 2020, 17(4):1212 Barboza L G A, Dick Vethaak A, Lavorante B R B O, et al. Marine microplastic debris:An emerging issue for food security, food safety and human health[J]. Marine Pollution Bulletin, 2018, 133:336-348 Bouwmeester H, Hollman P C H, Peters R J B. Potential health impact of environmentally released micro- and nanoplastics in the human food production chain:Experiences from nanotoxicology[J]. Environmental Science & Technology, 2015, 49(15):8932-8947 Domenech J, Hernández A, Rubio L, et al. Interactions of polystyrene nanoplastics with in vitro models of the human intestinal barrier[J]. Archives of Toxicology, 2020, 94(9):2997-3012 Hussain N, Jaitley V, Florence A T. Recent advances in the understanding of uptake of microparticulates across the gastrointestinal lymphatics[J]. Advanced Drug Delivery Reviews, 2001, 50(1-2):107-142 Eldridge J H, Meulbroek J A, Staas J K, et al. Vaccine-containing biodegradable microspheres specifically enter the gut-associated lymphoid tissue following oral administration and induce a disseminated mucosal immune response[J]. Advances in Experimental Medicine and Biology, 1989, 251:191-202 Jani P U, McCarthy D E, Florence A T. Nanosphere and microsphere uptake via Peyer's patches:Observation of the rate of uptake in the rat after a single oral dose[J]. International Journal of Pharmaceutics, 1992, 86(2-3):239-246 Volkheimer G. Hematogenous dissemination of ingested polyvinyl chloride particles[J]. Annals of the New York Academy of Sciences, 1975, 246:164-171 Banerjee A, Shelver W L. Micro- and nanoplastic induced cellular toxicity in mammals:A review[J]. Science of the Total Environment, 2021, 755:142518 Varela J A, Bexiga M G, Åberg C, et al. Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells[J]. Journal of Nanobiotechnology, 2012, 10:39 Nowak M, Brown T D, Graham A, et al. Size, shape, and flexibility influence nanoparticle transport across brain endothelium under flow[J]. Bioengineering & Translational Medicine, 2020, 5(2):e10153 Firdessa R, Oelschlaeger T A, Moll H. Identification of multiple cellular uptake pathways of polystyrene nanoparticles and factors affecting the uptake:Relevance for drug delivery systems[J]. European Journal of Cell Biology, 2014, 93(8-9):323-337 Gratton S E, Ropp P A, Pohlhaus P D, et al. The effect of particle design on cellular internalization pathways[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105(33):11613-11618 Carr K E, Smyth S H, McCullough M T, et al. Morphological aspects of interactions between microparticles and mammalian cells:Intestinal uptake and onward movement[J]. Progress in Histochemistry and Cytochemistry, 2012, 46(4):185-252 Schmidt C, Lautenschlaeger C, Collnot E M, et al. Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa:A first in vivo study in human patients[J]. Journal of Controlled Release:Official Journal of the Controlled Release Society, 2013, 165(2):139-145 Li S, Malmstadt N. Deformation and poration of lipid bilayer membranes by cationic nanoparticles[J]. Soft Matter, 2013, 9(20):4969-4976 Xie W, You J, Zhi C X, et al. The toxicity of ambient fine particulate matter (PM2.5) to vascular endothelial cells[J]. Journal of Applied Toxicology, 2021, 41(5):713-723 Gopinath P M, Saranya V, Vijayakumar S, et al. Assessment on interactive prospectives of nanoplastics with plasma proteins and the toxicological impacts of virgin, coronated and environmentally released-nanoplastics[J]. Scientific Reports, 2019, 9:8860 Hollóczki O, Gehrke S. Nanoplastics can change the secondary structure of proteins[J]. Scientific Reports, 2019, 9:16013 Goodman K E, Hare J T, Khamis Z I, et al. Exposure of human lung cells to polystyrene microplastics significantly retards cell proliferation and triggers morphological changes[J]. Chemical Research in Toxicology, 2021, 34(4):1069-1081 Xu M K, Halimu G, Zhang Q R, et al. Internalization and toxicity:A preliminary study of effects of nanoplastic particles on human lung epithelial cell[J]. The Science of the Total Environment, 2019, 694:133794 Cheng W, Li X L, Zhou Y, et al. Polystyrene microplastics induce hepatotoxicity and disrupt lipid metabolism in the liver organoids[J]. The Science of the Total Environment, 2022, 806(Pt 1):150328 Hirt N, Body-Malapel M. Immunotoxicity and intestinal effects of nano- and microplastics:A review of the literature[J]. Particle and Fibre Toxicology, 2020, 17(1):57 Muittari A, Veneskoski T. Natural and synthetic fibers as causes of asthma and rhinitis[J]. Annals of Allergy, 1978, 41(1):48-50 Pimentel J C, Avila R, Lourenço A G. Respiratory disease caused by synthetic fibres:A new occupational disease[J]. Thorax, 1975, 30(2):204-219 Li B Q, Ding Y F, Cheng X, et al. Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice[J]. Chemosphere, 2020, 244:125492 Liu S, Li H, Wang J, et al. Polystyrene microplastics aggravate inflammatory damage in mice with intestinal immune imbalance[J]. Science of the Total Environment, 2022, 833:155198 Deng Y F, Yan Z H, Shen R Q, et al. Microplastics release phthalate esters and cause aggravated adverse effects in the mouse gut[J]. Environment International, 2020, 143:105916 Shi C Z, Han X H, Guo W, et al. Disturbedgut-liver axis indicating oral exposure to polystyrene microplastic potentially increases the risk of insulin resistance[J]. Environment International, 2022, 164:107273 Jin Y X, Lu L, Tu W Q, et al. Impacts of polystyrene microplastic on the gut barrier, microbiota and metabolism of mice[J]. The Science of the Total Environment, 2019, 649:308-317 Hwang J, Choi D, Han S, et al. An assessment of the toxicity of polypropylene microplastics in human derived cells[J]. Science of the Total Environment, 2019, 684:657-669 Ding Y F, Zhang R Q, Li B Q, et al. Tissue distribution of polystyrene nanoplastics in mice and their entry, transport, and cytotoxicity to GES-1 cells[J]. Environmental Pollution, 2021, 280:116974 Domenech J, de Britto M, Velázquez A, et al. Long-term effects of polystyrene nanoplastics in human intestinal caco-2 cells[J]. Biomolecules, 2021, 11(10):1442 Eleutherio E C A, Silva Magalhães R S, de Araújo Brasil A, et al. SOD1, more than just an antioxidant[J]. Archives of Biochemistry and Biophysics, 2021, 697:108701 Johnson P. Antioxidant enzyme expression in health and disease:Effects of exercise and hypertension[J]. Comparative Biochemistry and Physiology Toxicology & Pharmacology, 2002, 133(4):493-505 Jakubczyk K, Dec K, Kałduńska J, et al. Reactive oxygen species-sources, functions, oxidative damage[J]. Polski Merkuriusz Lekarski:Organ Polskiego Towarzystwa Lekarskiego, 2020, 48(284):124-127 Wang X, Zheng H, Zhao J, et al. Photodegradation elevated the toxicity of polystyrene microplastics to grouper (Epinephelus moara) through disrupting hepatic lipid homeostasis[J]. Environmental Science & Technology, 2020, 54(10):6202-6212 DeLoid G M, Cao X Q, Bitounis D, et al. Toxicity, uptake, and nuclear translocation of ingested micro-nanoplastics in an in vitro model of the small intestinal epithelium[J]. Food and Chemical Toxicology:An International Journal Published for the British Industrial Biological Research Association, 2021, 158:112609 Bhagat J, Ingole B S. Glutathione S-transferase, catalase, superoxide dismutase, glutathione peroxidase, and lipid peroxidation as a biomarkers of oxidative stress in snails:A review[D]. Modena:University of Modena and Reggio Emilia, 2016:336-349 He Y J, Li Z, Xu T, et al. Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway[J]. Chemosphere, 2022, 307(Pt 1):135662 Deng Y F, Zhang Y, Lemos B, et al. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure[J]. Scientific Reports, 2017, 7:46687 Rubio L, Marcos R, Hernández A. Potential adverse health effects of ingested micro- and nanoplastics on humans. Lessons learned from in vivo and in vitro mammalian models[J]. Journal of Toxicology and Environmental Health Part B, Critical Reviews, 2020, 23(2):51-68 Powell J J, Thoree V, Pele L C. Dietary microparticles and their impact on tolerance and immune responsiveness of the gastrointestinal tract[J]. The British Journal of Nutrition, 2007, 98(Suppl 1):S59-S63 Huang D J, Zhang Y, Long J L, et al. Polystyrene microplastic exposure induces insulin resistance in mice via dysbacteriosis and pro-inflammation[J]. The Science of the Total Environment, 2022, 838(Pt 1):155937 Cortés C, Domenech J, Salazar M, et al. Nanoplastics as a potential environmental health factor:Effects of polystyrene nanoparticles on human intestinal epithelial Caco-2 cells[J]. Environmental Science:Nano, 2020, 7(1):272-285 Forte M, Iachetta G, Tussellino M, et al. Polystyrene nanoparticles internalization in human gastric adenocarcinoma cells[J]. Toxicology in Vitro, 2016, 31:126-136 Reuter S, Gupta S C, Chaturvedi M M, et al. Oxidative stress, inflammation, and cancer:How are they linked?[J]. Free Radical Biology and Medicine, 2010, 49(11):1603-1616 Yan X M, Zhang Y Y, Lu Y Q, et al. The complex toxicity of tetracycline with polystyrene spheres on gastric cancer cells[J]. International Journal of Environmental Research and Public Health, 2020, 17(8):2808 Chen Z X, Wang C Y, Yu N Z, et al. INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway[J]. Biomedecine & Pharmacotherapie, 2019, 111:151-161 Qiao J Y, Chen R, Wang M J, et al. Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction[J]. Nanoscale, 2021, 13(19):8806-8816 Lu L, Wan Z Q, Luo T, et al. Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice[J]. The Science of the Total Environment, 2018, 631-632:449-458 Zhao L T, Shi W Y, Hu F F, et al. Prolonged oral ingestion of microplastics induced inflammation in the liver tissues of C57BL/6J mice through polarization of macrophages and increased infiltration of natural killer cells[J]. Ecotoxicology and Environmental Safety, 2021, 227:112882 Wan Z Q, Wang C Y, Zhou J J, et al. Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish[J]. Chemosphere, 2019, 217:646-658 Zhao Y, Bao Z W, Wan Z Q, et al. Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish[J]. Science of the Total Environment, 2020, 710:136279 Shi L, Tu B P. Acetyl-CoA and the regulation of metabolism:Mechanisms and consequences[J]. Current Opinion in Cell Biology, 2015, 33:125-131 Zhou P, Santoro A, Peroni O D, et al. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms[J]. The Journal of Clinical Investigation, 2019, 129(10):4138-4150 Syed I, Lee J, Moraes-Vieira P M, et al. Palmitic acid hydroxystearic acids activate GPR40, which is involved in their beneficial effects on glucose homeostasis[J]. Cell Metabolism, 2018, 27(2):419-427.e4 Vijayakumar A, Aryal P, Wen J, et al. Absence of carbohydrate response element binding protein in adipocytes causes systemic insulin resistance and impairs glucose transport[J]. Cell Reports, 2017, 21(4):1021-1035 Wen B, Zhang N, Jin S R, et al. Microplastics have a more profound impact than elevated temperatures on the predatory performance, digestion and energy metabolism of an Amazonian cichlid[J]. Aquatic Toxicology, 2018, 195:67-76 Schlein C, Talukdar S, Heine M, et al. FGF21 lowers plasma triglycerides by accelerating lipoprotein catabolism in white and brown adipose tissues[J]. Cell Metabolism, 2016, 23(3):441-453 Iizuka K, Takeda J, Horikawa Y. Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes[J]. FEBS Letters, 2009, 583(17):2882-2886 Bi Y K, Chang Y, Liu Q, et al. ERp44/CG9911 promotes fat storage in Drosophila adipocytes by regulating ER Ca2+homeostasis[J]. Aging, 2021, 13(11):15013-15031 Simha V, Garg A. Lipodystrophy:Lessons in lipid and energy metabolism[J]. Current Opinion in Lipidology, 2006, 17(2):162-169 Iizuka K, Ken T K, Yabe D. ChREBP-mediated regulation of lipid metabolism:Involvement of the gut microbiota, liver, and adipose tissue[J]. Frontiers in Endocrinology, 2020, 11:587189 Nunes-Nesi A, Araújo W L, Obata T, et al. Regulation of the mitochondrial tricarboxylic acid cycle[J]. Current Opinion in Plant Biology, 2013, 16(3):335-343 Bougarne N, Weyers B, Desmet S J, et al. Molecular actions of PPARα in lipid metabolism and inflammation[J]. Endocrine Reviews, 2018, 39(5):760-802 Wang Q, Wu Y L, Zhang W J, et al. Lipidomics and transcriptomics insight into impacts of microplastics exposure on hepatic lipid metabolism in mice[J]. Chemosphere, 2022, 308(Pt 3):136591 Fan X P, Wei X J, Hu H L, et al. Effects of oral administration of polystyrene nanoplastics on plasma glucose metabolism in mice[J]. Chemosphere, 2022, 288(Pt 3):132607 Islinger M, Cardoso M J R, Schrader M. Be different-The diversity of peroxisomes in the animal kingdom[J]. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2010, 1803(8):881-897 Marion-Letellier R, Savoye G, Ghosh S. Fatty acids, eicosanoids and PPAR gamma[J]. European Journal of Pharmacology, 2016, 785:44-49 Bhatt-Wessel B, Jordan T W, Miller J H, et al. Role of DGAT enzymes in triacylglycerol metabolism[J]. Archives of Biochemistry and Biophysics, 2018, 655:1-11 Stone S J, Myers H M, Watkins S M, et al. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice[J]. The Journal of Biological Chemistry, 2004, 279(12):11767-11776 Stock V, Fahrenson C, Thuenemann A, et al. Impact of artificial digestion on the sizes and shapes of microplastic particles[J]. Food and Chemical Toxicology, 2020, 135:111010 Strandwitz P. Neurotransmitter modulation by the gut microbiota[J]. Brain Research, 2018, 1693(Pt B):128-133 -
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