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铁基金属有机骨架对中华青鳉毒性作用的持续性与恢复性

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叶君玉, 李衍红, 李以玲, 高阳, 夏斌, 崔正国, 曲克明. 铁基金属有机骨架对中华青鳉毒性作用的持续性与恢复性[J]. 生态毒理学报, 2025, 20(2): 152-160. doi: 10.7524/AJE.1673-5897.20250113001
引用本文: 叶君玉, 李衍红, 李以玲, 高阳, 夏斌, 崔正国, 曲克明. 铁基金属有机骨架对中华青鳉毒性作用的持续性与恢复性[J]. 生态毒理学报, 2025, 20(2): 152-160. doi: 10.7524/AJE.1673-5897.20250113001
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YE Junyu, LI Yanhong, LI Yiling, GAO Yang, XIA Bin, CUI Zhengguo, QU Keming. Persistence and Recovery of Toxicity Induced by Iron-Based Metal-Organic Framework to Chinese Medaka (Oryzias sinensis)[J]. Asian journal of ecotoxicology, 2025, 20(2): 152-160. doi: 10.7524/AJE.1673-5897.20250113001
Citation: YE Junyu, LI Yanhong, LI Yiling, GAO Yang, XIA Bin, CUI Zhengguo, QU Keming. Persistence and Recovery of Toxicity Induced by Iron-Based Metal-Organic Framework to Chinese Medaka (Oryzias sinensis)[J]. Asian journal of ecotoxicology, 2025, 20(2): 152-160. doi: 10.7524/AJE.1673-5897.20250113001
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铁基金属有机骨架对中华青鳉毒性作用的持续性与恢复性

  • 1. 海水养殖生物育种与可持续产出全国重点实验室, 中国水产科学研究院黄海水产研究所, 青岛 266071;

  • 2. 浙江海洋大学水产学院, 舟山 316022;

  • 3. 大连海洋大学水产与生命学院, 大连 116023

    • 作者简介: 叶君玉(1997—)，女，硕士研究生，研究方向为金属纳米材料渔业环境行为，E-mail:ye3374498428@163.com
    通讯作者: 李以玲,E-mail:liyiling@ysfri.ac.cn; 
  • 基金项目:

    山东省自然科学基金海外优青项目(2023HWYQ-103)；山东省泰山学者专项(tsqn202306296)；中国水产科学研究院基本科研业务费资助项目(20603022024017)

  • 中图分类号: X171.5

Persistence and Recovery of Toxicity Induced by Iron-Based Metal-Organic Framework to Chinese Medaka (Oryzias sinensis)

  • 1. State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China;

  • 2. Faculty of Fisheries, Zhejiang Ocean University, Zhoushan 316022, China;

  • 3. College of Fisheries and Life Science, Dalian Ocean University, Dalian 116023, China

    • Corresponding author: LI Yiling, liyiling@ysfri.ac.cn ; 
  • Fund Project:

  • 摘要: 铁基金属有机骨架(Fe-MOFs)在环境治理和修复领域展现出广泛的应用前景。然而，在Fe-MOFs合成、应用及处置等过程中，不可避免地会释放到水环境中，对生态系统和生物体造成潜在毒害作用。目前，关于Fe-MOFs生态毒性效应的研究仍较为有限。以中华青鳉(Oryzias sinensis)作为实验对象，探究了一种典型Fe-MOF(MIL-88B(Fe))对中华青鳉的毒性持久性和恢复性效应。实验将中华青鳉在0.4 mg·L-1的Fe-MOFs中胁迫14 d，随后进行14 d恢复阶段的观察。转录组学分析表明，在暴露阶段，Fe-MOFs显著影响了鱼体内核糖体功能、碳代谢、内质网蛋白质加工、糖酵解/糖异生以及丙酮酸代谢等关键生物学过程。在恢复阶段，神经活性配体-受体相互作用、cAMP信号通路、不饱和脂肪酸的生物合成和谷氨酸突触的破坏与Fe-MOFs诱导的毒性持久性密切相关。这些发现有助于揭示Fe-MOFs在鱼体内毒性效应的持续性及其恢复机制，对评估其生态环境风险具有重要的意义。
    Abstract: Iron-based metal-organic frameworks (Fe-MOFs) have garnered significant attention for their diverse applications in environmental fields. However, the increasing applications of Fe-MOFs raise concerns about their potential risks to living organisms. Nevertheless, the persistence and recovery of their toxicity remains largely unknown. Herein, two sub-experiments (exposure and recovery experiments) were conducted to reveal the persistence of the toxicity of a representative Fe-MOF, MIL-88B(Fe), to Chinese medaka (Oryzias sinensis). Oryzias sinensis were exposed to 0.4 mg·L-1 Fe-MOFs for 14 days. Transcriptome sequencing was employed to investigate the molecular responses of Oryzias sinensis during Fe-MOFs exposure and after recovery. During the exposure stage, Fe-MOFs significantly altered ribosome, carbon metabolism, protein processing in endoplasmic reticulum, glycolysis/gluconeogenesis, and pyruvate metabolism at exposure stage. In the recovery stage, disruption of neuroactive ligand-receptor interaction, cAMP signaling pathway, biosynthesis of unsaturated fatty acids, and glutamatergic synapse was linked to the persistence of Fe-MOFs induced toxicity. These findings highlight the mechanisms underlying the persistence of Fe-MOFs induced toxicity and provide critical insights for the accurate ecological risk assessment of Fe-MOFs.
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  • 收稿日期:  2025-01-13
叶君玉, 李衍红, 李以玲, 高阳, 夏斌, 崔正国, 曲克明. 铁基金属有机骨架对中华青鳉毒性作用的持续性与恢复性[J]. 生态毒理学报, 2025, 20(2): 152-160. doi: 10.7524/AJE.1673-5897.20250113001
引用本文: 叶君玉, 李衍红, 李以玲, 高阳, 夏斌, 崔正国, 曲克明. 铁基金属有机骨架对中华青鳉毒性作用的持续性与恢复性[J]. 生态毒理学报, 2025, 20(2): 152-160. doi: 10.7524/AJE.1673-5897.20250113001
shu
YE Junyu, LI Yanhong, LI Yiling, GAO Yang, XIA Bin, CUI Zhengguo, QU Keming. Persistence and Recovery of Toxicity Induced by Iron-Based Metal-Organic Framework to Chinese Medaka (Oryzias sinensis)[J]. Asian journal of ecotoxicology, 2025, 20(2): 152-160. doi: 10.7524/AJE.1673-5897.20250113001
Citation: YE Junyu, LI Yanhong, LI Yiling, GAO Yang, XIA Bin, CUI Zhengguo, QU Keming. Persistence and Recovery of Toxicity Induced by Iron-Based Metal-Organic Framework to Chinese Medaka (Oryzias sinensis)[J]. Asian journal of ecotoxicology, 2025, 20(2): 152-160. doi: 10.7524/AJE.1673-5897.20250113001
shu

铁基金属有机骨架对中华青鳉毒性作用的持续性与恢复性

    通讯作者: 李以玲,E-mail:liyiling@ysfri.ac.cn; 
    作者简介: 叶君玉(1997—)，女，硕士研究生，研究方向为金属纳米材料渔业环境行为，E-mail:ye3374498428@163.com
  • 1. 海水养殖生物育种与可持续产出全国重点实验室, 中国水产科学研究院黄海水产研究所, 青岛 266071;
  • 2. 浙江海洋大学水产学院, 舟山 316022;
  • 3. 大连海洋大学水产与生命学院, 大连 116023
  • 收稿日期:  2025-01-13
基金项目:

山东省自然科学基金海外优青项目(2023HWYQ-103)；山东省泰山学者专项(tsqn202306296)；中国水产科学研究院基本科研业务费资助项目(20603022024017)

摘要: 铁基金属有机骨架(Fe-MOFs)在环境治理和修复领域展现出广泛的应用前景。然而，在Fe-MOFs合成、应用及处置等过程中，不可避免地会释放到水环境中，对生态系统和生物体造成潜在毒害作用。目前，关于Fe-MOFs生态毒性效应的研究仍较为有限。以中华青鳉(Oryzias sinensis)作为实验对象，探究了一种典型Fe-MOF(MIL-88B(Fe))对中华青鳉的毒性持久性和恢复性效应。实验将中华青鳉在0.4 mg·L-1的Fe-MOFs中胁迫14 d，随后进行14 d恢复阶段的观察。转录组学分析表明，在暴露阶段，Fe-MOFs显著影响了鱼体内核糖体功能、碳代谢、内质网蛋白质加工、糖酵解/糖异生以及丙酮酸代谢等关键生物学过程。在恢复阶段，神经活性配体-受体相互作用、cAMP信号通路、不饱和脂肪酸的生物合成和谷氨酸突触的破坏与Fe-MOFs诱导的毒性持久性密切相关。这些发现有助于揭示Fe-MOFs在鱼体内毒性效应的持续性及其恢复机制，对评估其生态环境风险具有重要的意义。

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