生物样品中烷基酚类内分泌干扰物的前处理和分析方法
Pretreatment and analytical methods of alkylphenolic endocrine disrupters in biological samples
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摘要: 烷基酚类化合物具有与天然雌激素相似的结构,是一类典型的内分泌干扰物,被广泛应用于表面活性剂、纺织印染、橡胶塑料、油溶性酚醛树脂等领域,已经在环境介质中被广泛检测到.由于酚基类物质通常具有亲脂性和生物累积性,因此,生物样品中该类化合物的检测成为健康风险评价的关键.本文对近年来生物样品(生物组织、血液、尿液等)中烷基酚类物质的前处理技术与检测方法进行了综述,并对未来的发展趋势进行了展望.Abstract: Alkylphenolic compounds have similar structures to natural estrogen hormones, and are typical endocrine disrupters. They are widely used as surfactants, textile dyeing and finishing materials, rubbers and plastics, oil-soluble phenolic resins et al, and have been detected in various environmental compartments. Determination of alkylphenolic conpounds in biological samples is a key to estimate the associated health risk due to lipophilicity and bioaccumulation. The aim of this review was to present the pretreatment and analytical methods of alkylphenolic compounds in biological samples(including urine, blood, bile et al). In addition, outlook on the future developments was also presented.
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Key words:
- alkylphenol /
- biological samples /
- pretreatment /
- analytical methods
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