传感器在抗生素检测中的研究进展
Research progress on sensors in detection of antibiotics
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摘要: 抗生素滥用所造成的环境污染及食品安全问题日益受到关注.传感器具有灵敏度高、选择性好、易微型化和样品消耗少等优点，已被广泛用于抗生素的分析检测.本文介绍了抗生素的污染现状和主要检测方法，着重阐述了电化学传感器、光学传感器在抗生素检测中的最新研究成果，并对未来研究进行了展望.Abstract: Environmental pollution and food safety issues caused by the abuse of antibiotics have gained increasing attention. Sensors have been widely applied in analysis and detection of antibiotics due to their excellent sensitivity, high selectivity, easy miniaturization and low sample consumption. This paper summarizes the pollution situation and the main detection methods of antibiotics. The latest researches are highlighted on the electrochemical sensors and optial sensors in the detection of antibiotics. It is suggested that the development of new types of sensors needs to be further pursued for antibiotics detection in the future research.
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Key words:
- antibiotics /
- sensors /
- analysis and detection /
- research progress
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[1] 高立红,史亚利,厉文辉,等.抗生素环境行为及其环境效应研究进展[J].环境化学,2013,32(9):1619-1633. GAO L H,SHI Y L,LI W H,et al.Environmental behavior and impacts of antibiotics[J].Environmental Chemistry,2013,34(3):1619-1633(in Chinese).
[2] 黄宏,李圆杏,杨红伟.水环境中抗生素的光降解研究进展[J].环境化学,2013,32(7):1335-1341. HUANG H,LI Y X,YANG H W.Research progress on photodegradation of antibiotics in aqueous solution[J].Environmental Chemistry,2013,32(7):1335-1341(in Chinese).
[3] 章强,辛琦,朱静敏.中国主要水域抗生素污染现状及其生态环境效应研究进展[J].环境化学,2014,33(7):1075-1083. ZHANG Q,XIN Q,ZHU J M.The antibiotic contaminations in the main water bodies in China and the associated environmental and human health impacts[J].Environmental Chemistry,2014,33(7):1075-1083(in Chinese).
[4] TAGHDISI S M,DANESH N M,NAMEGHI M A,et al.A label-free fluorescent aptasensor for selective and sensitive detection of streptomycin in milk and blood serum[J].Food Chemistry,2016,203:145-149. [5] CAMARA M,GALLEGO-PICO A,GARCINUNO R M,et al.An HPLC-DAD method for the simultaneous determination of nine β-lactam antibiotics in ewe milk[J].Food Chemistry,2013,141(2):829-834. [6] 李鹏,邱月明,蔡慧霞,等.气相色谱-质谱联用法测定动物组织中氯霉素、氟甲砜霉素和甲砜霉素的残留量[J].色谱,2006,24(1):14-18. LI P,QIU Y M,CAI H X,et al.Simultaneous determination of chloramphenicol,thiamphenicol,and florfenicol residues in animal tissues by gas chromatography/mass spectrometry[J].Chinese Journal of Chromatography,2006,24(1):14-18(in Chinese).
[7] ROBERT C,GILLARD N,BRASSEUR P,et al.Rapid multiresidue and multi-class screening for antibiotics and benzimidazoles in feed by ultra high performance liquid chromatography coupled to tandem mass spectrometry[J].Food Control,2015,50:509-515. [8] 顿文涛,李勉,毕庆生,等.用于抗生素检测的生物传感器研究进展[J].生物技术通报,2013,6:70-74.DUN W T,LI M,BI Q S,et al.Research progress on biosensors for antibiotic detection[J].Biotechnology Bulletin,2013 ,6:70-74(in Chinese).
[9] 刘晓琴,唐洁.基于纳米界面电化学传感器的构建及其应用研究[J].应用化工,2013,42(4):731-733. LIU X Q,TANG J.Research on electrochemical sensors based onnano-interface and its application[J].Applied Chemical Industry,2013,42(4):731-733(in Chinese).
[10] Bakker E.Electrochemical sensors[J].Analytical Chemistry,2004,76(12):3285-3298. [11] 陈桂芳,梁志强,李根喜.纳米材料用于构建新型电化学生物传感器的研究进展[J].生物物理学报,2010,26(8):711-725. CHEN G F,LIANG Z Q,LI G X.Progress of electrochemical biosensors fabricated with nanomaterials[J].Acta Biophysica Sinica,2010,26(8):711-725(in Chinese).
[12] 张喜梅,陈玲,李琳,等.纳米材料制备研究现状及其发展方向[J].现代化工,2000,20(7):13-16. ZHANG X M,CHEN L,LI L,et al.Current research situation of nanomaterial preparation and its developing trend[J].Modern Chemical Industry,2000,20(7):13-16(in Chinese).
[13] WANG Z,YU J,GUI R,et al.Carbon nanomaterials-based electrochemical aptasensors[J].Biosensors&Bioelectronics,2015,79:136-149. [14] MORAES F C,SILVA T A,CESARINO I,et al.Antibiotic detection in urine using electrochemical sensors based on vertically aligned carbon nanotubes[J].Electroanalysis,2013,25(9):2092-2099. [15] 刘皓楠,刘艳.碳纳米复合材料在电化学生物传感器中的研究进展[J].化学传感器,2014,34(3):22-31. LIU H N,LIU Y.Applications of carbon nanocomposites in electrochemical biosensors[J].Chemical Sensors,2014,34(3):22-31(in Chinese).
[16] BOROWIEC J,WANG R,ZHU L,et al.Synthesis of nitrogen-doped grapheme nanosheets decorated with gold nanoparticles as an improved sensor for electrochemical determination of chloramphenicol[J].Electrochimica Acta,2013,99:138-144. [17] SAHA K,AGASTI S S,KIM C,et al.Gold nanoparticles in chemical and biological sensing[J].Chemical Reviews,2012,112(5):2739-2779. [18] ASADOLLAHI-BABOLI M,MANI-VARNOSFADERANI A.Rapid and simultaneous determination of tetracycline and cefixime antibiotics by mean of gold nanoparticles-screen printed gold electrode and chemometrics tools[J].Measurement,2014,47(1):145-149. [19] 李原婷,李大伟,宋伟,等.多壁碳纳米管修饰丝网印刷电极同时检测水中苯二酚异构体的研究[J].环境科学,2011,32(2):488-493. LI Y T,LI D W,SONG W,et al.Investigation on simultaneous determination of dihydroxybenzene isomers in water samples using multi-walled carbon nanotube modified screen-printed electrode[J].Chinese Journal of Environmental Science,2011,32(2):488-493(in Chinese).
[20] WANG J.Nanoparticle-based electrochemical bioassays of proteins[J].Electroanalysis,2007,19(19):769-776. [21] ZHANG,J L,TAN X C,ZHAO D D,et al.Fe3O4magnetic nanoparticles modified electrode as a sensor for determination of nimesulide[J].Chemical Research in Chinese Universities,2011,27(4):566-569. [22] LI Y,ZHANG L,LI M,et al.Adisposable biosensor based on immobilization of laccase with silica spheres on the MWCNTs-doped screen-printed electrode[J].Chemistry Central Journal,2012,6(1):103. [23] 刘佳,殷立峰,代云容,等.电化学酶传感器在环境污染监测中的应用[J].化学进展,2012,24(1):131-143. LIU J,YIN L F,DAI Y R,et al.Application of electrochemical enzyme biosensor in environmental pollution monitoring[J].Progress in Chemistry,2012,24(1):131-143(in Chinese).
[24] ISMAIL F,ADELOJU S B,MOLINE A N.Fabrication of a single layer and bilayer potentiometric biosensors for penicillin by galvanostatic entrapment of penicillinase into polypyrrolefilms[J].Electroanalysis,2014,26(12):2607-2618. [25] ISMAIL F,ADELOJU S B.The use of poly (vinyl alcohol) to cross-link penicillinase for the fabrication of a penicillin potentiometric biosensor[J].Electroanalysis,2014,26(12):2701-2709. [26] PRADO T M D,FOGUEL M V,GONCALVES L M,et al.β-Lactamase-based biosensor for the electrochemical determination of benzylpenicillin in milk[J].Sensors&Actuators B Chemical,2015,210(254):254-258. [27] WU Y,TANG L,HUANG L,et al.A low detection limit penicillin biosensor based on single grapheme nanosheets preadsorbed with hematein/ionic liquids/penicillinase[J].Materials Science&Engineering C,2014,39:92-99. [28] 汤琳,曾光明,黄国和,等.免疫传感器用于环境中痕量有害物质检测的研究进展[J].环境科学,2004,25(4):170-176. TANG L,ZENG G M,HUANG G H,et al.Study progress on determination of environmental trace toxicants by immunosensor[J].Chinese Journal of Environmental Science,2004,25(4):170-176(in Chinese).
[29] WEI Q,ZHAO Y,DU B,et al.Ultrasensitive detection of kanamycin in animal derived foods by label-free electrochemical immunosensor[J].Food Chemistry,2012,134(3):1601-1606. [30] KIM B,LIM D,JIN H J,et al.Family-selective detection of antibiotics using antibody-functionalized carbon nanotube sensors[J].Sensors&Actuators B Chemical,2012,166(10):193-199. [31] WU X,KUANG H,HAO C,et al.Paper supported immunosensor for detection of antibiotics[J].Biosensors&Bioelectronics,2012,33(1):309-312. [32] KIM Y J,KIM Y S,NIAZI J H,et al.Electrochemical aptasensor for tetracycline detection[J].Bioprocess&Biosystems Engineering,2010,33(1):31-37. [33] ZHOU L,LI D,GAI L,et al.Electrochemical aptasensor for the detection of tetracycline with multi-walled carbon nanotubes amplification[J].Sensors&Actuators B Chemical,2012,162(1):201-208. [34] CHEN D,YAO D,XIE C,et al.Development of an aptasensor for electrochemical detection of tetracycline[J].Food Control,2014,42(3):109-115. [35] YADAV S K,AGRAWAL B,CHANDRA P,et al.In vitro chloramphenicol detection in a Haemophilus influenza model using an aptamer-polymer based electrochemical biosensor[J].Biosensors&Bioelectronics,2014,55(4):337-342. [36] SCHOUKROUN-BARNES L R,WAGAN S,WHITE R J,et al.Enhancing the analytical performance of eectrochemical RNA aptamer-based sensors for sensitive detection of aminoglycoside antibiotics[J].Analytical Chemistry,2014,86(2):1131-1137. [37] KAZUYPSHI K,KOJI S.Theoretical understanding of an absorption-based surface plasmon resonance sensor based on Kretchmann's theory[J].Analytical Chemistry,2002,74(3):696-701. [38] 刘瑾,王文,张婉洁,等.基于表面等离子体共振传感器信号放大的抗生素残留检测[J].分析试验室,2012,31(11):5-9. LIU J,WANG W,ZHANG W J,et al.Detection of antibiotic residues using signal amplification assay based on SPR sensors[J].Chinese Journal of Analysis Laboratory,2012,31(11):5-9(in Chinese).
[39] FERNANDEZ F,HEGNEROVA K,PILIARIK M,et al.A label-free and portable multichannel surface plasmon resonance immunesensor for on site analysis of antibiotics in milk samples[J].Biosensors and Bioelectronics,2010,26(4):1231-1238. [40] WU S,ZHANG H,SHI Z,et al.Aptamer-based fluorescence biosensor for chloramphenicol determination using upconversion nanoparticles[J].Food Control,2015,50(4):597-604. [41] LI R Z,LIU Y,CHENG L,et al.Photoelectrochemical aptasensing of kanamycin using visible light-activated carbon nitride and grapheneoxide nanocomposites[J].Analytical Chemistry,2014,86(19):9372-9375. [42] CHEN A,JIANG X,ZHANG W,et al.High sensitive rapid visual detection of sulfadimethoxine by label-free aptasensor[J].Biosensors&Bioelectronics,2013,42(1):419-425. [43] WANG S,YONG W,LIU J,et al.Development of an indirect competitive assay-based aptasensor for highly sensitive detection of tetracycline residue in honey[J].Biosensors&Bioelectronics,2014,57(21):192-198. [44] KIM C H,LEE L P,MIN J R,et al.An indirect competitive assay-based aptasensor for detection of oxytetracycline in milk[J].Biosensors&Bioelectronics,2014,51(1):426-430. [45] 马君,孔德地,韩晓红,等.应用银溶胶膜探测水中抗生素的表面增强拉曼光谱研究[J].光谱学与光谱分析,2013,33(10):2688-2693. MA J,KONG D D,HAN X H,et al.Detection of antibiotics in water using silver colloid films as substrate of surface-enhanced Raman scattering[J].Spectroscopy and Spectral Analysis,2013,33(10):2688-2693(in Chinese).
[46] LEE S,KUMAR P,HU Y,et al.Graphene laminated gold bipyramids as sensitivedetection platforms for antibiotic molecules[J].Chemical Communications,2015,51(85):15494-15497. [47] CHEN J,FENG S L,GAO F,et al.Fabrication of SERS-active substrates using silvernanofilm-coated porous anodic aluminum oxidefor detection of antibiotics[J].Journal of Food Science,2015,82(1):162. [48] LI Y T,QU L L,LI D W,et al.Rapid and sensitive in-situ detection of polar antibiotics in water using a disposable Ag-graphene sensor based on electrostatic preconcentration and surface-enhanced Raman spectroscopy[J].Biosensors and Bioelectronics,2013,43:94-100. [49] SUN M,DING B,LIN J,et al.Three-dimensional sensing membrane functionalized quartz crystal microbalance biosensor for chloramphenicol detection in real time[J].Sensors&Actuators B Chemical,2011,160(1):428-434. [50] HOU H,BAI X,XING C,et al.Aptamer-based cantilever array sensors for oxytetracycline detection[J].Analytical Chemistry,2013,85(4):2010-2014. [51] BAI X,HOU H,ZHANG B,et al.Label-free detection of kanamycin using aptamer-based cantilever array sensor[J].Biosensors&Bioelectronics,2014,56c (18):112-116. [52] MA X H,LI J P,WANG C,et al.A review on bio-macromolecular imprinted sensors and their applications[J].Chinese Journal of Analytical Chemistry,2016,44(1):152-159. [53] ZDUNEK J,BENITO-PENA E,LINARES A,et al.Surface-imprinted nanofilaments for europium-amplified luminescent detection of fluoroquinoloneantibiotics[J].Chemistry-A European Journal,2013,19(31):10209-10216. [54] KARA M,UZUN L,KOLAYLI S,et al.Combining molecular imprinted nanoparticles with surface plasmonresonance nanosensor for chloramphenicol detection in honey[J].Journal of Applied Polymer Science,2013,129(4):2273-2279. [55] GAO F,FENG S,CHEN Z,et al.Detection and quantification of chloramphenicol in milk and honey using molecularly imprinted polymers:Canadian penny-based SERS nano-biosensor[J].Journal of Food Science,2014,79(12):N2542-N2549. -
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