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饮用水中九种卤乙酰胺的高效液相色谱-三重四极杆质谱测定方法

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周亚男, 王芬, 李亚静, 季民, 翟洪艳. 饮用水中九种卤乙酰胺的高效液相色谱-三重四极杆质谱测定方法[J]. 环境化学, 2017, 36(3): 614-620. doi: 10.7524/j.issn.0254-6108.2017.03.2016071806
引用本文: 周亚男, 王芬, 李亚静, 季民, 翟洪艳. 饮用水中九种卤乙酰胺的高效液相色谱-三重四极杆质谱测定方法[J]. 环境化学, 2017, 36(3): 614-620. doi: 10.7524/j.issn.0254-6108.2017.03.2016071806
shu
ZHOU Yanan, WANG Fen, LI Yajing, JI Min, ZHAI Hongyan. Determination of nine haloacetamides in drinking water using high performance liquid chromatography-triple quadropole mass spectrometry[J]. Environmental Chemistry, 2017, 36(3): 614-620. doi: 10.7524/j.issn.0254-6108.2017.03.2016071806
Citation: ZHOU Yanan, WANG Fen, LI Yajing, JI Min, ZHAI Hongyan. Determination of nine haloacetamides in drinking water using high performance liquid chromatography-triple quadropole mass spectrometry[J]. Environmental Chemistry, 2017, 36(3): 614-620. doi: 10.7524/j.issn.0254-6108.2017.03.2016071806
shu

饮用水中九种卤乙酰胺的高效液相色谱-三重四极杆质谱测定方法

  • 1.

    天津大学环境科学与工程学院, 天津, 300350;

  • 2.

    天津城建大学环境与市政工程学院, 天津, 300384

  • 基金项目:

    国家自然科学基金（21207096）和天津大学自主创新基金（2013XQ-0048）资助.

Determination of nine haloacetamides in drinking water using high performance liquid chromatography-triple quadropole mass spectrometry

  • 1.

    School of Environmental Science and Engineering, Tianjin University, Tianjin, 300350, China;

  • 2.

    School of Environmental and Municipal Engineering, Tianjin Chengjian University, Tianjin, 300384, China

  • Fund Project: Supported by the National Natural Science Foundation of China(21207096)and Seed Foundation of Tianjin University(2013XQ-0048).

  • 摘要: 本文应用固相萃取前处理方法和高效液相色谱-三重四极杆电喷雾质谱（HPLC-ESI/tqMS），优化并建立了9种氯代和溴代乙酰胺的同时测定方法.结果显示，在流动相甲醇/水（5/95，V/V）、流速0.3 mL·min-1、正离子模式条件下，9种卤乙酰胺的线性范围是5-200 μg·L-1或10-500 μg·L-1（R2>0.99），9种卤乙酰胺检出限为0.5-9.2 μg·L-1.经过比较HLB是最优的固相萃取柱.在0.02、0.2、0.5 μg·L-1的3个加标水平下，9种卤乙酰胺的回收率分别为61%-84%、60%-93%和70%-104%，相对标准偏差为1.7%-4.4%、1.1%-4.1%和0.8%-4.1%.
    Abstract: In this study, a new method for the simultaneous determination of nine chlorinated and brominated haloacetamides in drinking water was developed using solid phase extraction (SPE) and high performance liquid chromatography-triple quadropole mass spectrometry (HPLC-tqMS) with positive electron spray ionization. The optimized HPLC mobile phase was composed of methanol and water (5/95, V/V) with a flow rate of 0.3 mL·min-1. The linear ranges of the HPLC-tqMS method were 5-200 μg·L-1 or 10-500 μg·L-1 (R2>0.99) for the nine haloacetamides. The detection limits of the nine haloacetamides were 0.5-9.2 μg·L-1. HLB column was found to be the optimal SPE column. With the spiked concentrations of 0.02, 0.2 and 0.5 μg·L-1, the recovery rates of the nine haloacetamides were 61%-84%, 60%-93% and 70%-104%, respectively (relative standard deviations were 1.7%-4.4%, 1.1%-4.1% and 0.8%-4.1%, respectively).
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  • [1] RICHARDSON S D, PLEWA M J, WAGNER E D, et al. Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water:A review and roadmap for research[J]. Mutation Research/Reviews in Mutation Research, 2007, 636(1-3):178-242.
    [2] 赵玉丽,李杏放. 饮用水消毒副产物:化学特性与毒性[J]. 环境化学,2011, 30(1):20-33.

    ZHAO Y L, LI X F. Disinfection by-products in drinking water:Chemical characteristics and toxicity[J]. Environmental Chemistry, 2011, 30(1):20-33(in Chinese).

    [3] TOM B, HUANG J, TEMPLETON M R, et al. Occurrence and control of nitrogenous disinfection by-product in drinking water:A review[J]. Water Research, 2011, 45:4341-4354.
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    [6] RICHARDSON S D, THRUSTON A D, KRASNER S W, et al. Integrated disinfection by-products mixtures research:Comprehensive characterization of water concentrates prepared from chlorinated and ozonated/postchlorinated drinking water[J]. Journal of Toxicology and Environmental Health, 2008, 71(17):1165-1186.
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  • 收稿日期:  2016-07-18
  • 刊出日期:  2017-03-15
周亚男, 王芬, 李亚静, 季民, 翟洪艳. 饮用水中九种卤乙酰胺的高效液相色谱-三重四极杆质谱测定方法[J]. 环境化学, 2017, 36(3): 614-620. doi: 10.7524/j.issn.0254-6108.2017.03.2016071806
引用本文: 周亚男, 王芬, 李亚静, 季民, 翟洪艳. 饮用水中九种卤乙酰胺的高效液相色谱-三重四极杆质谱测定方法[J]. 环境化学, 2017, 36(3): 614-620. doi: 10.7524/j.issn.0254-6108.2017.03.2016071806
shu
ZHOU Yanan, WANG Fen, LI Yajing, JI Min, ZHAI Hongyan. Determination of nine haloacetamides in drinking water using high performance liquid chromatography-triple quadropole mass spectrometry[J]. Environmental Chemistry, 2017, 36(3): 614-620. doi: 10.7524/j.issn.0254-6108.2017.03.2016071806
Citation: ZHOU Yanan, WANG Fen, LI Yajing, JI Min, ZHAI Hongyan. Determination of nine haloacetamides in drinking water using high performance liquid chromatography-triple quadropole mass spectrometry[J]. Environmental Chemistry, 2017, 36(3): 614-620. doi: 10.7524/j.issn.0254-6108.2017.03.2016071806
shu

饮用水中九种卤乙酰胺的高效液相色谱-三重四极杆质谱测定方法

  • 1.  天津大学环境科学与工程学院, 天津, 300350;
  • 2.  天津城建大学环境与市政工程学院, 天津, 300384
  • 收稿日期:  2016-07-18
基金项目:

国家自然科学基金（21207096）和天津大学自主创新基金（2013XQ-0048）资助.

摘要: 本文应用固相萃取前处理方法和高效液相色谱-三重四极杆电喷雾质谱（HPLC-ESI/tqMS），优化并建立了9种氯代和溴代乙酰胺的同时测定方法.结果显示，在流动相甲醇/水（5/95，V/V）、流速0.3 mL·min-1、正离子模式条件下，9种卤乙酰胺的线性范围是5-200 μg·L-1或10-500 μg·L-1（R2>0.99），9种卤乙酰胺检出限为0.5-9.2 μg·L-1.经过比较HLB是最优的固相萃取柱.在0.02、0.2、0.5 μg·L-1的3个加标水平下，9种卤乙酰胺的回收率分别为61%-84%、60%-93%和70%-104%，相对标准偏差为1.7%-4.4%、1.1%-4.1%和0.8%-4.1%.

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