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酮洛芬在臭氧作用下的降解机制、产物及毒性

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林晓璇, 孔青青, 曾泳钦, 陆一达, 刘国光, 吕文英. 酮洛芬在臭氧作用下的降解机制、产物及毒性[J]. 环境化学, 2018, 37(5): 1063-1070. doi: 10.7524/j.issn.0254-6108.2017071101
引用本文: 林晓璇, 孔青青, 曾泳钦, 陆一达, 刘国光, 吕文英. 酮洛芬在臭氧作用下的降解机制、产物及毒性[J]. 环境化学, 2018, 37(5): 1063-1070. doi: 10.7524/j.issn.0254-6108.2017071101
shu
LIN Xiaoxuan, KONG Qingqing, ZENG Yongqin, LU Yida, LIU Guoguang, LYV Wenying. Study on mechanism, intermediates and toxicity of ketoprofen degradation by ozone[J]. Environmental Chemistry, 2018, 37(5): 1063-1070. doi: 10.7524/j.issn.0254-6108.2017071101
Citation: LIN Xiaoxuan, KONG Qingqing, ZENG Yongqin, LU Yida, LIU Guoguang, LYV Wenying. Study on mechanism, intermediates and toxicity of ketoprofen degradation by ozone[J]. Environmental Chemistry, 2018, 37(5): 1063-1070. doi: 10.7524/j.issn.0254-6108.2017071101
shu

酮洛芬在臭氧作用下的降解机制、产物及毒性

  • 1.

    广东工业大学环境科学与工程学院, 广州, 510006

  • 基金项目:

    国家自然科学基金（21377031）资助.

Study on mechanism, intermediates and toxicity of ketoprofen degradation by ozone

  • 1.

    School of Environmental Science and Technology, Guangdong University of Technology, Guangzhou, 510006, China

  • Fund Project: Supported by the National Natural Science Foundation of China(21377031).

  • 摘要: 利用臭氧（O3）氧化降解酮洛芬（KET），采用淬灭实验探究了实验过程中KET的降解机理，鉴定了降解中间产物，推测了其降解路径，并且对KET降解过程中的急性毒性进行了评价.结果表明，臭氧能有效降解KET，其降解符合一级动力学.降解过程中臭氧和羟基自由基（·OH）共同作用于KET.KET降解过程中生成了21种主要产物，其中包括3-乙基二苯甲酮、3-（1-过氧化氢乙基）-二苯甲酮、3-（1-乙酰基）-二苯甲酮等产物，降解路径包括羟基化、脱羧基、脱甲基、侧链氧化、酮基断裂等.明亮发光杆菌急性毒性实验表明KET降解过程中生成了较母体更高风险的中间产物.
    Abstract: Degradation of ketoprofen(KET) by ozone(O3) was investigated in this study. Quenching experiments were adopted to explore the mechanism of KET ozonation. Degradation intermediates were identified and the transformation paths were speculated, the acute toxicity during the process was evaluated as well. Results showed that KET could be efficiently degraded by ozone and the degradation rate fitted pseudo-first-order kinetics well. KET was degraded by both O3 and hydroxyl radicals (·OH). Formation of twenty-one aromatic converted products were observed during KET degradation, including 3-ethylbenzophenone, 3-(1-hydroperoxyethyl) benzophenone, 3-(1-hydroxyethyl) benzophenone. Transformation paths were conjectured as hydroxylation, decarboxylate, demethylation, side-chain oxidation, keto-break. Toxicity experiments indicated that higher risk of intermediates arose in the process of degradation.
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  • 收稿日期:  2017-07-11
  • 刊出日期:  2018-05-15
林晓璇, 孔青青, 曾泳钦, 陆一达, 刘国光, 吕文英. 酮洛芬在臭氧作用下的降解机制、产物及毒性[J]. 环境化学, 2018, 37(5): 1063-1070. doi: 10.7524/j.issn.0254-6108.2017071101
引用本文: 林晓璇, 孔青青, 曾泳钦, 陆一达, 刘国光, 吕文英. 酮洛芬在臭氧作用下的降解机制、产物及毒性[J]. 环境化学, 2018, 37(5): 1063-1070. doi: 10.7524/j.issn.0254-6108.2017071101
shu
LIN Xiaoxuan, KONG Qingqing, ZENG Yongqin, LU Yida, LIU Guoguang, LYV Wenying. Study on mechanism, intermediates and toxicity of ketoprofen degradation by ozone[J]. Environmental Chemistry, 2018, 37(5): 1063-1070. doi: 10.7524/j.issn.0254-6108.2017071101
Citation: LIN Xiaoxuan, KONG Qingqing, ZENG Yongqin, LU Yida, LIU Guoguang, LYV Wenying. Study on mechanism, intermediates and toxicity of ketoprofen degradation by ozone[J]. Environmental Chemistry, 2018, 37(5): 1063-1070. doi: 10.7524/j.issn.0254-6108.2017071101
shu

酮洛芬在臭氧作用下的降解机制、产物及毒性

  • 1. 广东工业大学环境科学与工程学院, 广州, 510006
  • 收稿日期:  2017-07-11
基金项目:

国家自然科学基金（21377031）资助.

摘要: 利用臭氧（O3）氧化降解酮洛芬（KET），采用淬灭实验探究了实验过程中KET的降解机理，鉴定了降解中间产物，推测了其降解路径，并且对KET降解过程中的急性毒性进行了评价.结果表明，臭氧能有效降解KET，其降解符合一级动力学.降解过程中臭氧和羟基自由基（·OH）共同作用于KET.KET降解过程中生成了21种主要产物，其中包括3-乙基二苯甲酮、3-（1-过氧化氢乙基）-二苯甲酮、3-（1-乙酰基）-二苯甲酮等产物，降解路径包括羟基化、脱羧基、脱甲基、侧链氧化、酮基断裂等.明亮发光杆菌急性毒性实验表明KET降解过程中生成了较母体更高风险的中间产物.

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