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多溴联苯醚对芳香烃受体的激活作用及其介导毒性的研究进展

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梅楠, 池泉, 肖华明, 王献. 多溴联苯醚对芳香烃受体的激活作用及其介导毒性的研究进展[J]. 环境化学, 2020, (1): 50-60. doi: 10.7524/j.issn.0254-6108.2019082904
引用本文: 梅楠, 池泉, 肖华明, 王献. 多溴联苯醚对芳香烃受体的激活作用及其介导毒性的研究进展[J]. 环境化学, 2020, (1): 50-60. doi: 10.7524/j.issn.0254-6108.2019082904
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MEI Nan, CHI Quan, XIAO Huaming, WANG Xian. Review on the study of activation effects of polybrominated diphenyl ethers on aryl hydrocarbon receptors and mediated toxicity[J]. Environmental Chemistry, 2020, (1): 50-60. doi: 10.7524/j.issn.0254-6108.2019082904
Citation: MEI Nan, CHI Quan, XIAO Huaming, WANG Xian. Review on the study of activation effects of polybrominated diphenyl ethers on aryl hydrocarbon receptors and mediated toxicity[J]. Environmental Chemistry, 2020, (1): 50-60. doi: 10.7524/j.issn.0254-6108.2019082904
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多溴联苯醚对芳香烃受体的激活作用及其介导毒性的研究进展

  • 中南民族大学化学与材料科学学院, 分析化学国家民委重点实验室, 武汉, 430074

    • 通讯作者: 王献, E-mail: xwang27@mail.scuec.edu.cn
  • 基金项目:

    国家自然科学基金（21675176）资助.

Review on the study of activation effects of polybrominated diphenyl ethers on aryl hydrocarbon receptors and mediated toxicity

  • Key Laboratory of Analytical Chemistry of State Ethnic Affairs Commission, College of Chemistry and Materials Science, South-Central University for Nationalities, Wuhan, 430074, China

    • Corresponding author: WANG Xian, xwang27@mail.scuec.edu.cn
  • Fund Project: Supported by the National Natural Science Foundation of China (21675176).

  • 摘要: 多溴联苯醚（polybrominated diphenyl ethers，PBDEs）是一类全球广泛存在的有机污染物，由于具有环境持久性，远距离传输，生物可累积性及对生物和人体有毒害效应等特性，是当前环境科学的热点研究对象之一.PBDEs的毒性包括生殖毒性、神经毒性、内分泌干扰、DNA损伤、免疫影响等，对人类以及环境具有潜在的威胁.芳香烃受体（aryl hydrocarbon receptor，AhR）是一种配体激活转录因子，诱导许多编码药物代谢酶的基因，可以被二噁英强效激活并引发一系列毒性.PBDEs具有与二噁英相似的结构，而被认为是一种潜在的AhR配体，但是PBDEs通过AhR介导的毒性机理仍然不明确.本文介绍和讨论了近10多年来PBDEs对AhR激活作用的研究，以及诱导的基因表达和毒性效应.虽然各文献的研究手段以及结论不尽相同，大多数研究表明大部分PBDEs对AhR的激活效果较为微弱，但仍有些PBDE需要引起重视.例如，BDE-126在大鼠肝细胞中的激活作用比其同系物更为突出，BDE-99可以激活斑马鱼胚胎中的AhR.此外，大多数羟基化或甲氧基化多溴联苯醚在家禽胚胎肝细胞、大鼠肝癌细胞中可以激活AhR，且可能比PBDEs具有更高的毒性和生物积累性.
    Abstract: Polybrominated diphenyl ethers (PBDEs) as a class of organic pollutants are widely used in the world. Due to their environmental persistence, long-distance transport, bioaccumulation and toxic effects on organisms and humans, the toxicity of PBDEs is currently one of the popular research objectives in environmental science. The toxicity of PBDEs includes reproductive toxicity, neurotoxicity, endocrine disruption, DNA damage, immune effects, etc., which potentially threaten human beings and the environment. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that induces many the drug-metabolizing enzymes of genes encoding. It can be potently activated by dioxins and trigger a range of toxicities. PBDEs have structural similarities to dioxins and are also considered to be a potential AhR ligand. However, the mechanism of the toxicity of PBDEs via AhR remains unclear. This review article has summarized the research on the effects of PBDEs on the activation of AhR, induced gene expression and toxicity in the past decade. Although methods and conclusions in literatures were different, general results showed that most PBDEs had a weak effect on the activation of AhR, but some PBDEs need to be paid attention. For instance, the activation effect of BDE-126 was stronger than its homologues; BDE-99 could activate AhR in the zebrafish embryo. Moreover, hydroxylated or methoxylated polybrominated diphenyl ethers could activate AhR in both poultry embryonic liver cells and rat liver cancer cells, indicating that they might have higher toxicity and more bioaccumulation than the corresponding PBDEs.
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  • 收稿日期:  2019-08-29
  • 刊出日期:  2020-01-01

多溴联苯醚对芳香烃受体的激活作用及其介导毒性的研究进展

    通讯作者: 王献, E-mail: xwang27@mail.scuec.edu.cn
  • 中南民族大学化学与材料科学学院, 分析化学国家民委重点实验室, 武汉, 430074
  • 收稿日期:  2019-08-29
  • 网络出版日期:  2020-01-01
基金项目:

国家自然科学基金（21675176）资助.

摘要: 多溴联苯醚（polybrominated diphenyl ethers，PBDEs）是一类全球广泛存在的有机污染物，由于具有环境持久性，远距离传输，生物可累积性及对生物和人体有毒害效应等特性，是当前环境科学的热点研究对象之一.PBDEs的毒性包括生殖毒性、神经毒性、内分泌干扰、DNA损伤、免疫影响等，对人类以及环境具有潜在的威胁.芳香烃受体（aryl hydrocarbon receptor，AhR）是一种配体激活转录因子，诱导许多编码药物代谢酶的基因，可以被二噁英强效激活并引发一系列毒性.PBDEs具有与二噁英相似的结构，而被认为是一种潜在的AhR配体，但是PBDEs通过AhR介导的毒性机理仍然不明确.本文介绍和讨论了近10多年来PBDEs对AhR激活作用的研究，以及诱导的基因表达和毒性效应.虽然各文献的研究手段以及结论不尽相同，大多数研究表明大部分PBDEs对AhR的激活效果较为微弱，但仍有些PBDE需要引起重视.例如，BDE-126在大鼠肝细胞中的激活作用比其同系物更为突出，BDE-99可以激活斑马鱼胚胎中的AhR.此外，大多数羟基化或甲氧基化多溴联苯醚在家禽胚胎肝细胞、大鼠肝癌细胞中可以激活AhR，且可能比PBDEs具有更高的毒性和生物积累性.

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