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地表水中典型磺胺类抗生素的自然衰减

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李妍, 张一清, 于昌平, 孙倩. 地表水中典型磺胺类抗生素的自然衰减[J]. 环境化学, 2021, (3): 696-705. doi: 10.7524/j.issn.0254-6108.2019100805
引用本文: 李妍, 张一清, 于昌平, 孙倩. 地表水中典型磺胺类抗生素的自然衰减[J]. 环境化学, 2021, (3): 696-705. doi: 10.7524/j.issn.0254-6108.2019100805
shu
LI Yan, ZHANG Yiqing, YU Changping, SUN Qian. Natural attenuation behavior of typical sulfonamides in the surface water[J]. Environmental Chemistry, 2021, (3): 696-705. doi: 10.7524/j.issn.0254-6108.2019100805
Citation: LI Yan, ZHANG Yiqing, YU Changping, SUN Qian. Natural attenuation behavior of typical sulfonamides in the surface water[J]. Environmental Chemistry, 2021, (3): 696-705. doi: 10.7524/j.issn.0254-6108.2019100805
shu

地表水中典型磺胺类抗生素的自然衰减

  • 1. 中国科学院城市环境研究所, 中国科学院城市污染物转化重点实验室, 厦门, 361021;

  • 2. 中国科学院大学, 北京, 100049

    • 通讯作者: 孙倩, E-mail: qsun@iue.ac.cn
  • 基金项目:

    国家自然科学基金（41573102）和福建省自然科学基金杰出青年基金（2017J06013）资助.

Natural attenuation behavior of typical sulfonamides in the surface water

  • 1. CAS Key Laboratory of Urban Pollutant Conversion, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China;

  • 2. University of Chinese Academy of Sciences, Beijing, 100049, China

    • Corresponding author: SUN Qian, qsun@iue.ac.cn
  • Fund Project: Supported by the National Natural Science Foundation of China (41573102) and Distinguished Young Scholars of Fujian Province (2017J06013).

  • 摘要: 近年来，磺胺类抗生素因大量使用，在河流等地表水中广泛检出，其环境行为及生态危害，成为备受关注的环境问题.本文以10种常见磺胺类抗生素为研究对象，通过微宇宙实验，模拟其在河流表层水中的自然衰减规律，同时模拟直接光降解、间接光降解、水解、细菌降解和微生物降解等多种条件，以阐明不同环境因素对磺胺类抗生素自然衰减的作用机制.结果显示，10种磺胺类抗生素在168 h内的自然衰减率可达55%—100%，半衰期为14.7—115.5 h，表明磺胺类抗生素在进入河流等地表水后可发生自然衰减.结构方程模型分析表明，直接光降解及间接光降解是磺胺类抗生素自然衰减的主要途径，而水解和微生物降解的作用不大.采用高分辨率质谱，共检出7种降解产物，推测磺胺类抗生素的转化路径主要包括N—S键断裂及羟基化作用.ECOSAR毒性分析结果表明，转化产物毒性多低于母体抗生素，但仍可能存在潜在的环境风险，需进一步深入研究.
    Abstract: Due to its extensive usage and frequent detection in the surface water, the environmental behavior and ecological toxicity of sulfonamides have received increasing concerns. This study investigated the attenuation pattern and factors influencing the natural attenuation of 10 typical sulfonamides by simulating hydrolysis, direct and indirect photolysis, bacterial degradation and microbial degradation in microcosm. The results showed that 55% to 100% of sulfonamides could be removed under natural attenuation with the half-life from 14.7 h to 115.5 h, which indicated the sulfonamides can be naturally attenuated after entering the river surface water. The structural equation modeling approach demonstrated that the direct and indirect photolysis were the major factors contributing to the natural attenuation of sulfonamides, while hydrolysis, bacterial degradation, and microbial degradation were not effective. Seven transformation products were identified by high resolution mass spectrometry, which suggested that the sulfonamides attenuation mainly occurred through N-S cleavage and hydroxylation. The toxicity evaluation based on ECOSAR showed that the toxicity of the transformation products was lower than the parent compounds. However, the transformation products might still have potential environmental risks and further studies should be conducted.
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  • 收稿日期:  2019-10-08
李妍, 张一清, 于昌平, 孙倩. 地表水中典型磺胺类抗生素的自然衰减[J]. 环境化学, 2021, (3): 696-705. doi: 10.7524/j.issn.0254-6108.2019100805
引用本文: 李妍, 张一清, 于昌平, 孙倩. 地表水中典型磺胺类抗生素的自然衰减[J]. 环境化学, 2021, (3): 696-705. doi: 10.7524/j.issn.0254-6108.2019100805
shu
LI Yan, ZHANG Yiqing, YU Changping, SUN Qian. Natural attenuation behavior of typical sulfonamides in the surface water[J]. Environmental Chemistry, 2021, (3): 696-705. doi: 10.7524/j.issn.0254-6108.2019100805
Citation: LI Yan, ZHANG Yiqing, YU Changping, SUN Qian. Natural attenuation behavior of typical sulfonamides in the surface water[J]. Environmental Chemistry, 2021, (3): 696-705. doi: 10.7524/j.issn.0254-6108.2019100805
shu

地表水中典型磺胺类抗生素的自然衰减

    通讯作者: 孙倩, E-mail: qsun@iue.ac.cn
  • 1. 中国科学院城市环境研究所, 中国科学院城市污染物转化重点实验室, 厦门, 361021;
  • 2. 中国科学院大学, 北京, 100049
  • 收稿日期:  2019-10-08
基金项目:

国家自然科学基金（41573102）和福建省自然科学基金杰出青年基金（2017J06013）资助.

摘要: 近年来，磺胺类抗生素因大量使用，在河流等地表水中广泛检出，其环境行为及生态危害，成为备受关注的环境问题.本文以10种常见磺胺类抗生素为研究对象，通过微宇宙实验，模拟其在河流表层水中的自然衰减规律，同时模拟直接光降解、间接光降解、水解、细菌降解和微生物降解等多种条件，以阐明不同环境因素对磺胺类抗生素自然衰减的作用机制.结果显示，10种磺胺类抗生素在168 h内的自然衰减率可达55%—100%，半衰期为14.7—115.5 h，表明磺胺类抗生素在进入河流等地表水后可发生自然衰减.结构方程模型分析表明，直接光降解及间接光降解是磺胺类抗生素自然衰减的主要途径，而水解和微生物降解的作用不大.采用高分辨率质谱，共检出7种降解产物，推测磺胺类抗生素的转化路径主要包括N—S键断裂及羟基化作用.ECOSAR毒性分析结果表明，转化产物毒性多低于母体抗生素，但仍可能存在潜在的环境风险，需进一步深入研究.

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