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邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展

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罗艺文, 高盼, 闫路, 张效伟, 于红霞, 史薇, 于南洋. 邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展[J]. 环境化学, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
引用本文: 罗艺文, 高盼, 闫路, 张效伟, 于红霞, 史薇, 于南洋. 邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展[J]. 环境化学, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
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LUO Yiwen, GAO Pan, YAN Lu, ZHANG Xiaowei, YU Hongxia, SHI Wei, YU Nanyang. Research progress on endocrine disruption effect of di-n-butyl phthalate, diisobutyl phthalate and substitutes[J]. Environmental Chemistry, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
Citation: LUO Yiwen, GAO Pan, YAN Lu, ZHANG Xiaowei, YU Hongxia, SHI Wei, YU Nanyang. Research progress on endocrine disruption effect of di-n-butyl phthalate, diisobutyl phthalate and substitutes[J]. Environmental Chemistry, 2021, (1): 11-27. doi: 10.7524/j.issn.0254-6108.2020080602
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邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展

  • 污染控制与资源化研究国家重点实验室, 南京大学环境学院, 南京, 210023

    • 通讯作者: 于南洋, E-mail: yuny@nju.edu.cn
  • 基金项目:

    国家重点研发计划（2018YFC1801604），国家自然科学基金（21922603），江苏省优秀青年科学基金（BK20170077），中央高校基本科研业务费专项资金（021114380139）和国家水污染控制与处理科技重大项目（2017ZX07202-001，2017ZX07602-002）资助.

Research progress on endocrine disruption effect of di-n-butyl phthalate, diisobutyl phthalate and substitutes

  • State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, 210023, China

    • Corresponding author: YU Nanyang, yuny@nju.edu.cn
  • Fund Project: Supported by the National Key R&D Program of China (2018YFC1801604), the Natural Science Foundation of China (21922603), the Science Fund for Excellent Young Scholars of Jiangsu Province (BK20170077), the Fundamental Research Funds for the Central Universities (021114380139) and the National Water Pollution Control and Treatment Science and Technology Major Project (2017ZX07202-001, 2017ZX07602-002).

  • 摘要: 邻苯二甲酸二丁酯（di-n-butyl phthalate，DnBP）和邻苯二甲酸二异丁酯（diisobutyl phthalate，DiBP）是广泛用于塑料、树脂和橡胶制品中的邻苯二甲酸酯类增塑剂，曾在各种环境介质中频繁检出.现有研究表明，DnBP和DiBP对人类和其他动物具有显著的内分泌干扰效应以及生殖发育毒性等不良影响，因而在许多国家和地区被限制使用，由此市面上涌现出了一些替代品增塑剂.本文结合国内外关于DnBP和DiBP及其替代品的研究成果，综述了DnBP和DiBP在个体、细胞和分子水平上的内分泌干扰效应与机制以及在市场应用中的替代情况，并且选取了4种典型的替代品（邻苯二甲酸二异壬酯、环己烷-1，2-二羧酸二异壬酯、二苯甲酸二聚丙二醇酯、三乙酸甘油酯）对其内分泌干扰效应进行对比分析.研究结果表明，DnBP和DiBP在环境低浓度下能够影响类固醇激素合成通路中关键基因的表达，进而改变生物体内类固醇激素的水平，高浓度暴露时则会对生殖器官造成损伤并最终降低生殖能力，妊娠期暴露还会对后代产生相同的影响.DnBP和DiBP的4种替代品在急性毒性、持久性和生物可累积性方面均有所降低，内分泌干扰效应也显著降低，但缺乏系统的研究以全面评估其可替代性.提出今后替代品的安全性评估应纳入更多的毒性终点并深入研究相关的毒性效应机制，以保证替代化学品的安全性.
    Abstract: Di-n-butyl phthalate (DnBP) and diisobutyl phthalate (DiBP) are phthalate plasticizers being widely used in plastics, resins and rubber products, which can be frequently detected in various environmental matrices. Existing studies have shown that DnBP and DiBP have significant endocrine disrupting effects and adverse effects on humans and other animals, such as reproductive and developmental toxicity. Therefore, their use is restricted in many countries and regions. As a result, some substitutive plasticizers have emerged on the market. Based on domestic and international studies on DnBP, DiBP and their substitutes, this article reviews the endocrine disrupting effects of DnBP and DiBP at individual, cellular and molecular levels, and summarizes their mechanisms of endocrine disrupting effects and their substitutive plasticizers on the market. Four typical substitutes (diisononyl phthalate, diisononyl cyclohexane-1,2-dicarboxylate, dipropylene glycol dibenzoate and glyceryl triacetate) are selected for comparative analysis of their endocrine disrupting effects. Research results show that DnBP and DiBP can affect the expression of key genes in the steroid hormone synthesis pathway at low environmental concentrations, thereby changing the level of steroid hormones in the organism. They will cause damage to the reproductive organs and ultimately reduce reproductive capacity at high concentrations, and the same effect on offspring have been reported due to the exposure during pregnancy. The four alternatives of DnBP and DiBP have reduced the acute toxicity, persistence and bioaccumulation, and endocrine disrupting effects of them have also been significantly reduced. However, there is a lack of systematic studies to fully evaluate their substitutability. It is recommended that future safety assessment of alternatives should include more toxicity endpoints and in-depth study of mechanisms of related toxic effects to ensure the safety of substitutes.
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邻苯二甲酸二(异)丁酯及其替代品的内分泌干扰效应研究进展

    通讯作者: 于南洋, E-mail: yuny@nju.edu.cn
  • 污染控制与资源化研究国家重点实验室, 南京大学环境学院, 南京, 210023
  • 收稿日期:  2020-08-06
基金项目:

国家重点研发计划（2018YFC1801604），国家自然科学基金（21922603），江苏省优秀青年科学基金（BK20170077），中央高校基本科研业务费专项资金（021114380139）和国家水污染控制与处理科技重大项目（2017ZX07202-001，2017ZX07602-002）资助.

摘要: 邻苯二甲酸二丁酯（di-n-butyl phthalate，DnBP）和邻苯二甲酸二异丁酯（diisobutyl phthalate，DiBP）是广泛用于塑料、树脂和橡胶制品中的邻苯二甲酸酯类增塑剂，曾在各种环境介质中频繁检出.现有研究表明，DnBP和DiBP对人类和其他动物具有显著的内分泌干扰效应以及生殖发育毒性等不良影响，因而在许多国家和地区被限制使用，由此市面上涌现出了一些替代品增塑剂.本文结合国内外关于DnBP和DiBP及其替代品的研究成果，综述了DnBP和DiBP在个体、细胞和分子水平上的内分泌干扰效应与机制以及在市场应用中的替代情况，并且选取了4种典型的替代品（邻苯二甲酸二异壬酯、环己烷-1，2-二羧酸二异壬酯、二苯甲酸二聚丙二醇酯、三乙酸甘油酯）对其内分泌干扰效应进行对比分析.研究结果表明，DnBP和DiBP在环境低浓度下能够影响类固醇激素合成通路中关键基因的表达，进而改变生物体内类固醇激素的水平，高浓度暴露时则会对生殖器官造成损伤并最终降低生殖能力，妊娠期暴露还会对后代产生相同的影响.DnBP和DiBP的4种替代品在急性毒性、持久性和生物可累积性方面均有所降低，内分泌干扰效应也显著降低，但缺乏系统的研究以全面评估其可替代性.提出今后替代品的安全性评估应纳入更多的毒性终点并深入研究相关的毒性效应机制，以保证替代化学品的安全性.

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