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张玉琳, 罗双艳, 赵亚娴, 陈星羽, 刘芃岩, 李圆圆, 秦占芬. 抗生素制药企业废水处理全过程中毒性评价[J]. 生态毒理学报, 2025, 20(2): 161-170. doi: 10.7524/AJE.1673-5897.20241106001
引用本文: 张玉琳, 罗双艳, 赵亚娴, 陈星羽, 刘芃岩, 李圆圆, 秦占芬. 抗生素制药企业废水处理全过程中毒性评价[J]. 生态毒理学报, 2025, 20(2): 161-170. doi: 10.7524/AJE.1673-5897.20241106001
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ZHANG Yulin, LUO Shuangyan, ZHAO Yaxian, CHEN Xingyu, LIU Pengyan, LI Yuanyuan, QIN Zhanfen. Toxicity Evaluation of Antibiotic Pharmaceutical Wastewater in the Whole Treatment Process[J]. Asian journal of ecotoxicology, 2025, 20(2): 161-170. doi: 10.7524/AJE.1673-5897.20241106001
Citation: ZHANG Yulin, LUO Shuangyan, ZHAO Yaxian, CHEN Xingyu, LIU Pengyan, LI Yuanyuan, QIN Zhanfen. Toxicity Evaluation of Antibiotic Pharmaceutical Wastewater in the Whole Treatment Process[J]. Asian journal of ecotoxicology, 2025, 20(2): 161-170. doi: 10.7524/AJE.1673-5897.20241106001
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抗生素制药企业废水处理全过程中毒性评价

  • 1. 河北大学生态环境系, 保定 071002;

  • 2. 中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室, 北京 100085;

  • 3. 生态环境部环境发展中心环境标准样品研究所, 北京 100029;

  • 4. 生态环境部污染物计量和标准样品研究重点实验室, 北京 100029

    • 作者简介: 张玉琳(2000—)，女，硕士研究生，研究方向为环境毒理学，E-mail:18736012313@163.com
    通讯作者: 刘芃岩,E-mail:hbupyliu@163.com;  李圆圆,E-mail:yyli@rcees.ac.cn; 
  • 基金项目:

    国家重点研发项目(2023YFC3207100)；生态环境部污染物计量和标准样品研究重点实验室开放课题(KF202305)

  • 中图分类号: X171.5

Toxicity Evaluation of Antibiotic Pharmaceutical Wastewater in the Whole Treatment Process

  • 1. School of Eco-Environment, Hebei University, Baoding 071002, China;

  • 2. State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;

  • 3. Institute of Environmental Reference Materials, Environmental Development Center of the Ministry of Ecology and Environment, Beijing 100029, China;

  • 4. Ministry of Ecology and Environment Key Laboratory of Environmental Pollutant Metrology and Reference Materials, Beijing 100029, China

    • Corresponding authors: LIU Pengyan ;  LI Yuanyuan ; 
  • Fund Project:

  • 摘要: 抗生素制药废水处理工艺不仅决定最终受纳水体和再生水的生态安全，同时也关系着处理过程中生化处理系统的稳定性。本研究综合利用发光细菌试验、抑菌圈试验、活性污泥呼吸抑制试验以及斑马鱼胚胎毒性试验等多种方法，分析某制药企业在生物处理、膜分离、分盐及蒸发等工艺阶段，25个样品的抗生素废水水样的毒性和抑菌活性。我们的结果发现，末端排放废水和再生水未检测到明显的发光细菌毒性、斑马鱼胚胎发育毒性以及抗菌活性，提示不存在明显的生态风险；但是在废水处理过程中，经厌氧和缺氧处理后，进入好氧系统前的水样显著抑制好氧活性污泥的呼吸作用，表明废水可能对好氧生化系统存在潜在的不利影响，需要优化上一级处理工艺。我们的结果可为该企业的废水处理工艺优化提供指导，同时多项毒性测试方法的整合使用也为同类企业废水的毒性和抗性评价提供了方法学的参考。
    Abstract: The treatment process for antibiotic pharmaceutical wastewater not only determines the ecological safety of the final effluent and reclaimed water but also is related to the stability of the biochemical treatment system. This study employed the bacterial bioluminescence assay, the zone of inhibition test, the activated sludge oxygen uptake inhibition test and zebrafish embryo toxicity test to evaluate the toxicity and antibacterial activity of 25 samples from an antibiotic pharmaceutical factory, in the process of biological treatment, membrane separation, salt separation and evaporation for wastewater. We found that the final effluent and the reclaimed water did not exert significant toxicities in the bacterial bioluminescence assay and zebrafish embryo toxicity test and the antibacterial activity, suggesting limited ecological risk. However, the water samples after anaerobic and anoxic treatments and before entering the aerobic system inhibited the respiration of aerobic activated sludge, indicating potential adverse effects on the aerobic biochemical system and the need to optimize the upper treatment process. Our results can provide a guidance for the optimization of the wastewater treatment process of this factory. Meanwhile, the integrated use of several toxicity test methods provides a methodological reference for the toxicity and resistance evaluation of wastewater in the same type of factories.
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  • SONG Y F, ZHANG Z H, LIU Y B, et al. Enhancement of anaerobic treatment of antibiotic pharmaceutical wastewater through the development of iron-based and carbon-based materials: a critical review[J]. Journal of hazardous materials, 2024, 479: 135514.
    BIELEN A, ŠIMATOVIC[DD(-2.1mm][HT6]＇[HT5"][] A, KOSIC[DD(-2.1mm][HT6]＇[HT5"][]-VUKŠIC[DD(-2.1mm][HT6]＇[HT5"][] J, et al. Negative environmental impacts of antibiotic-contaminated effluents from pharmaceutical industries[J]. Water research, 2017, 126: 79-87.
    World Health Organization. Guidance on wastewater and solid waste management for manufacturing of antibiotics[R]. Geneva: World Health Organization, 2023: 1-47.
    HU J R, LYU Y T, CHEN H, et al. Suspect and nontarget screening reveal the underestimated risks of antibiotic transformation products in wastewater treatment plant effluents[J]. Environmental science & technology, 2023, 57(45): 17439-17451.
    GUDDA F O, WAIGI M G, ODINGA E S, et al. Antibiotic-contaminated wastewater irrigated vegetables pose resistance selection risks to the gut microbiome[J]. Environmental pollution, 2020, 264: 114752.
    生态环境部. 水质急性毒性的测定斑马鱼卵法: HJ 1069—2019[S]. 北京: 生态环境部, 2019: 1-19.
    国家环境保护总局. 城镇污水处理厂污染物排放标准: GB 18918—2002[S]. 北京: 国家环境保护总局, 2002: 1-8.
    黑龙江省市场监督管理局. 水质生物毒性的测定发光细菌快速测定法: DB23/T 2750—2020[S]. 哈尔滨: 黑龙江省市场监督管理局, 2020: 1-4.
    何锦垚, 魏健, 张嘉雯, 等. 臭氧催化氧化-BAF组合工艺深度处理抗生素制药废水[J]. 环境工程学报, 2019, 13(10): 2385-2392.

    HE J Y, WEI J, ZHANG J W, et al. Advanced treatment of antibiotic pharmaceutical wastewater by catalytic ozonation combined with BAF process[J]. Chinese journal of environmental engineering, 2019, 13(10): 2385-2392.

    彭安萍, 高虎, 张新波. 制药废水中抗生素抗性的污染特征、检测手段和控制方法[J]. 环境科学, 2024, 45(2): 844-853.

    PENG A P, GAO H, ZHANG X B. Contamination characteristics, detection methods, and control methods of antibiotic resistance in pharmaceutical wastewater[J]. Environmental science, 2024, 45(2): 844-853.

    生态环境部. 污水监测技术规范: HJ 91.1—2019[S]. 北京: 生态环境部, 2019: 1-13.
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    XU Y Q, LIU S S, WANG Z J, et al. Commercial personal care product mixtures exhibit hormetic concentration-responses to Vibrio qinghaiensis sp.-Q67[J]. Ecotoxicology and environmental safety, 2018, 162: 304-311.
    XIONG Y M, CHEN X Y, LI F, et al. Zebrafish larvae acute toxicity test: a promising alternative to the fish acute toxicity test[J]. Aquatic toxicology, 2022, 246: 106143.
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  • 收稿日期:  2024-11-06
张玉琳, 罗双艳, 赵亚娴, 陈星羽, 刘芃岩, 李圆圆, 秦占芬. 抗生素制药企业废水处理全过程中毒性评价[J]. 生态毒理学报, 2025, 20(2): 161-170. doi: 10.7524/AJE.1673-5897.20241106001
引用本文: 张玉琳, 罗双艳, 赵亚娴, 陈星羽, 刘芃岩, 李圆圆, 秦占芬. 抗生素制药企业废水处理全过程中毒性评价[J]. 生态毒理学报, 2025, 20(2): 161-170. doi: 10.7524/AJE.1673-5897.20241106001
shu
ZHANG Yulin, LUO Shuangyan, ZHAO Yaxian, CHEN Xingyu, LIU Pengyan, LI Yuanyuan, QIN Zhanfen. Toxicity Evaluation of Antibiotic Pharmaceutical Wastewater in the Whole Treatment Process[J]. Asian journal of ecotoxicology, 2025, 20(2): 161-170. doi: 10.7524/AJE.1673-5897.20241106001
Citation: ZHANG Yulin, LUO Shuangyan, ZHAO Yaxian, CHEN Xingyu, LIU Pengyan, LI Yuanyuan, QIN Zhanfen. Toxicity Evaluation of Antibiotic Pharmaceutical Wastewater in the Whole Treatment Process[J]. Asian journal of ecotoxicology, 2025, 20(2): 161-170. doi: 10.7524/AJE.1673-5897.20241106001
shu

抗生素制药企业废水处理全过程中毒性评价

    通讯作者: 刘芃岩,E-mail:hbupyliu@163.com;  李圆圆,E-mail:yyli@rcees.ac.cn; 
    作者简介: 张玉琳(2000—)，女，硕士研究生，研究方向为环境毒理学，E-mail:18736012313@163.com
  • 1. 河北大学生态环境系, 保定 071002;
  • 2. 中国科学院生态环境研究中心环境化学与生态毒理学国家重点实验室, 北京 100085;
  • 3. 生态环境部环境发展中心环境标准样品研究所, 北京 100029;
  • 4. 生态环境部污染物计量和标准样品研究重点实验室, 北京 100029
  • 收稿日期:  2024-11-06
基金项目:

国家重点研发项目(2023YFC3207100)；生态环境部污染物计量和标准样品研究重点实验室开放课题(KF202305)

摘要: 抗生素制药废水处理工艺不仅决定最终受纳水体和再生水的生态安全，同时也关系着处理过程中生化处理系统的稳定性。本研究综合利用发光细菌试验、抑菌圈试验、活性污泥呼吸抑制试验以及斑马鱼胚胎毒性试验等多种方法，分析某制药企业在生物处理、膜分离、分盐及蒸发等工艺阶段，25个样品的抗生素废水水样的毒性和抑菌活性。我们的结果发现，末端排放废水和再生水未检测到明显的发光细菌毒性、斑马鱼胚胎发育毒性以及抗菌活性，提示不存在明显的生态风险；但是在废水处理过程中，经厌氧和缺氧处理后，进入好氧系统前的水样显著抑制好氧活性污泥的呼吸作用，表明废水可能对好氧生化系统存在潜在的不利影响，需要优化上一级处理工艺。我们的结果可为该企业的废水处理工艺优化提供指导，同时多项毒性测试方法的整合使用也为同类企业废水的毒性和抗性评价提供了方法学的参考。

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