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高效液相色谱-电喷雾串联质谱法测定婴幼儿奶粉中对羟基苯甲酸酯类防腐剂

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吴红庆, 厉文辉, 高立红, 刘杰民. 高效液相色谱-电喷雾串联质谱法测定婴幼儿奶粉中对羟基苯甲酸酯类防腐剂[J]. 环境化学, 2020, (1): 275-278.
引用本文: 吴红庆, 厉文辉, 高立红, 刘杰民. 高效液相色谱-电喷雾串联质谱法测定婴幼儿奶粉中对羟基苯甲酸酯类防腐剂[J]. 环境化学, 2020, (1): 275-278.
shu
WU Hongqing, LI Wenhui, GAO Lihong, LIU Jiemin. Determination of parabens in infant milk powders by high performance liquid chromatography-electrospray ionization tandem mass spectrometry[J]. Environmental Chemistry, 2020, (1): 275-278.
Citation: WU Hongqing, LI Wenhui, GAO Lihong, LIU Jiemin. Determination of parabens in infant milk powders by high performance liquid chromatography-electrospray ionization tandem mass spectrometry[J]. Environmental Chemistry, 2020, (1): 275-278.
shu

高效液相色谱-电喷雾串联质谱法测定婴幼儿奶粉中对羟基苯甲酸酯类防腐剂

  • 1. 北京科技大学化学与生物工程学院, 北京, 100083;

  • 2. 遵义市公安司法鉴定中心, 遵义, 563000;

  • 3. 赛默飞世尔科技(中国)有限公司应用研发中心, 北京, 100102

Determination of parabens in infant milk powders by high performance liquid chromatography-electrospray ionization tandem mass spectrometry

  • 1. Chemistry and Biology Engineering School, University of Science and Technology Beijing, Beijing, 100083, China;

  • 2. Zunyi Public Security Judicial Identification Center, Zunyi, 563000, China;

  • 3. Thermofisher Scientific China Limited Application Research Center, Beijing, 100102, China

摘要

  • 摘要: 建立了高效液相色谱-串联质谱法检测奶粉中8种对羟基苯甲酸酯类防腐剂的分析方法.样品以乙腈为提取溶剂，经HLB固相萃取柱富集净化，分别用甲醇和丙酮溶液洗脱，洗脱液经氮吹浓缩定容后，高效液相色谱-串联质谱仪进行分析.8种对羟基苯甲酸酯加标浓度在5、50、100 ng·g-1时的回收率分别为71.1%—96.1%、72.8%—99.8%和78.8%—118%，相对标准偏差（RSD）为3.2%—10%（n=5），内标法定量，方法检出限为0.04—0.43 ng·g-1.将建立的方法应用于市场常见品牌的婴幼儿奶粉样品的分析，结果表明7个品牌奶粉样品中共有5种防腐剂检出.
    Abstract: A method for the determination of 8 parabens in infant milk powders by using high performance liquid chromatography-electrospray ionization tandem mass spectrometry was developed. The target preservatives in infant milk powders were extracted by acetonitrile and cleaned-up by HLB solid-phrase extraction, and then eluted with methanol and acetone solutions respectively. The eluate was collected and concentrated under a gentle stream of nitrogen gas, and then analyzed by HPLC-ESI-MS/MS. The recoveries of 8 parabens in infant milk powders at 3 levels (5,10 and 100 ng·g-1) were 78.8%-118%,72.8%-99.8% and 71.1%-96.1% and relative standard deviation (RSD, n=5) was 3.2%-10%. The method detection limits were 0.04-0.43 ng·g-1. This developed method was applied to analyze the infant milk powders in Beijing and results showed that some PBs were detected all in seven samples.
  • [1] JIMÉNEZ-DÍAZ I, VELA-SORIA F, RODRÍGUEZ-GÓMEZ R, et al. Analytical methods for the assessment of endocrine disrupting chemical exposure during human fetal and lactation stages[J].Analytica Chimica Acta, 2015, 892:27-48.
    [2] GRZEŚKOWIAK T, CZARCZYŃSKA-GOŚLIŃSKA B, ZGOŁA-GRZEŃKOWIAK A. Current approaches in sample preparation for trace analysis of selected endocrine-disrupting compounds:Focus on polychlorinated biphenyls, alkylphenols, and parabens[J]. Trends in Analytical Chemistry,2016, 75:209-226.
    [3] ESIMBEKOVA E N, ASANOVA A A, DEEVA A A, et al. Inhibition effect of food preservatives on endoproteinases[J]. Food Chemistry, 2017, 235:294-297.
    [4] LENNERZ B, VAFAI S B, DELANEY N F, et al. Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans[J]. Molecular Genetics & Metabolism, 2015, 114(1):73-79.
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  • 刊出日期:  2020-01-01
吴红庆, 厉文辉, 高立红, 刘杰民. 高效液相色谱-电喷雾串联质谱法测定婴幼儿奶粉中对羟基苯甲酸酯类防腐剂[J]. 环境化学, 2020, (1): 275-278.
引用本文: 吴红庆, 厉文辉, 高立红, 刘杰民. 高效液相色谱-电喷雾串联质谱法测定婴幼儿奶粉中对羟基苯甲酸酯类防腐剂[J]. 环境化学, 2020, (1): 275-278.
shu
WU Hongqing, LI Wenhui, GAO Lihong, LIU Jiemin. Determination of parabens in infant milk powders by high performance liquid chromatography-electrospray ionization tandem mass spectrometry[J]. Environmental Chemistry, 2020, (1): 275-278.
Citation: WU Hongqing, LI Wenhui, GAO Lihong, LIU Jiemin. Determination of parabens in infant milk powders by high performance liquid chromatography-electrospray ionization tandem mass spectrometry[J]. Environmental Chemistry, 2020, (1): 275-278.
shu

高效液相色谱-电喷雾串联质谱法测定婴幼儿奶粉中对羟基苯甲酸酯类防腐剂

  • 1. 北京科技大学化学与生物工程学院, 北京, 100083;
  • 2. 遵义市公安司法鉴定中心, 遵义, 563000;
  • 3. 赛默飞世尔科技(中国)有限公司应用研发中心, 北京, 100102
  • 网络出版日期:  2020-01-01

摘要: 建立了高效液相色谱-串联质谱法检测奶粉中8种对羟基苯甲酸酯类防腐剂的分析方法.样品以乙腈为提取溶剂，经HLB固相萃取柱富集净化，分别用甲醇和丙酮溶液洗脱，洗脱液经氮吹浓缩定容后，高效液相色谱-串联质谱仪进行分析.8种对羟基苯甲酸酯加标浓度在5、50、100 ng·g-1时的回收率分别为71.1%—96.1%、72.8%—99.8%和78.8%—118%，相对标准偏差（RSD）为3.2%—10%（n=5），内标法定量，方法检出限为0.04—0.43 ng·g-1.将建立的方法应用于市场常见品牌的婴幼儿奶粉样品的分析，结果表明7个品牌奶粉样品中共有5种防腐剂检出.

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