磷酸三丁酯的生物毒性效应研究进展
Research Progress on Biological Toxicity Effects of Tributyl Phosphate
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摘要: 作为传统溴代阻燃剂的替代品，有机磷酸酯阻燃剂（organophosphate flame retardants，OPFRs）已广泛用于制造业，对环境造成的影响备受人们关注，成为新有机污染物的研究热点之一。目前，烷基OPFRs在各种环境介质中被频繁检出，通过吸入、饮食摄入或皮肤接触等途径进入生物体内，产生一定的毒性效应，对生态系统和人类健康具有潜在的风险。本文总结了一类烷基OPFR——磷酸三丁酯（tributyl phosphate，TBP）在生物体内的富集、毒性效应和作用机制，提出了当前研究中存在的问题和建议，同时展望了生物毒性评价的发展趋势，为今后全面评估TBP的生态风险提供依据。Abstract: Organophosphate flame retardants (OPFRs), as alternatives to conventional brominated flamed retardants, have been widely used in the manufacturing industry. Their impact on the environment has raised public concern and become a research hotspot in the field of new organic pollutants. Currently, alkyl OPFRs have been detected frequently in various environmental media, leading to their accumulation in organisms through inhalation, dietary intake, or dermal contact, and consequent toxic effects on organisms. Therefore, alkyl OPFRs have potential risks on ecosystem and human health. In this review, we summarized the bioaccumulation in organisms, toxicity, and mechanisms of tributyl phosphate (TBP), an alkyl OPFR. We also raised some issues and made some suggestions in this research field, and prospected the development trend of biological toxicity assessment. Our work provides a potential means by which the ecological risk of TBP will be evaluated systematically in the future.
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