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超高效液相色谱-串联质谱法同时测定环境水体中15种精神类药物

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金苗, 杨慧婷, 陈辉辉, 沈幸, 王钰洋, 沈睿杰. 超高效液相色谱-串联质谱法同时测定环境水体中15种精神类药物[J]. 环境化学, 2020, (12): 3588-3592.
引用本文: 金苗, 杨慧婷, 陈辉辉, 沈幸, 王钰洋, 沈睿杰. 超高效液相色谱-串联质谱法同时测定环境水体中15种精神类药物[J]. 环境化学, 2020, (12): 3588-3592.
shu
JIN Miao, YANG Huiting, CHEN Huihui, SHEN Xing, WANG Yuyang, SHEN Ruijie. Simultaneous determination of 15 psychotropic substances in environmental water by ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry[J]. Environmental Chemistry, 2020, (12): 3588-3592.
Citation: JIN Miao, YANG Huiting, CHEN Huihui, SHEN Xing, WANG Yuyang, SHEN Ruijie. Simultaneous determination of 15 psychotropic substances in environmental water by ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry[J]. Environmental Chemistry, 2020, (12): 3588-3592.
shu

超高效液相色谱-串联质谱法同时测定环境水体中15种精神类药物

  • 1. 中国科学院南京地理与湖泊研究所湖泊与环境国家重点实验室, 南京, 210008;

  • 2. 中国科学院大学, 北京, 100049;

  • 3. 内蒙古大学生态与环境学院, 内蒙古自治区环境污染控制与废物资源化重点实验室, 呼和浩特, 010021

    • 通讯作者: 陈辉辉, E-mail: hhchen@niglas.ac.cn ; 
  • 基金项目:

    国家自然科学基金（41907222）和中国科学院饮用水科学与技术重点实验室专项经费（20K05KLDWST）资助.

Simultaneous determination of 15 psychotropic substances in environmental water by ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry

  • 1. State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, Nanjing, 210008, China;

  • 2. University of Chinese Academy of Sciences, Beijing, 100049, China;

  • 3. Inner Mongolia Key Laboratory of Environmental Pollution Control&Waste Resource Reuse, School of Ecology and Environment, Inner Mongolia University, Hohhot, 010021, China

    • Corresponding author: CHEN Huihui, hhchen@niglas.ac.cn ; 
  • Fund Project: Supported by the National Natural Science Foundation of China (41907222) and Special Fund from Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences (20K05KLDWST).

  • 摘要: 采用固相萃取-超高效液相色谱串联质谱技术建立水中抗抑郁类、抗癫痫类、抗精神分裂类共15种精神类药物分析测定方法.水体样品经过Oasis HLB固相萃取柱进行富集后以ACQUITY UPLC BEH C18为分析柱，采用UPLC-MS/MS多反应监测离子（MRM）模式进行检测，同时外标法定量.结果表明，所建立的方法在1.0—200 μg·L-1范围内线性关系良好，相关系数R2均大于0.99；检出限为1.05—9.90 ng·L-1，加标回收率为65.69%—105.53%，相对标准偏差均小于10%（n=6），该法灵敏度高，分析速度快，满足痕量分析测试的要求，应用该方法测定了太湖水体中精神类药物的残留浓度水平，发现有11种物质可被不同程度检出，浓度范围为0.8—77.6 ng·L－1.
    Abstract: A simultaneous determination method for 15 kinds of psychotropic substances including antiepileptic,Antidepressants and Antischizophrenic in groundwater was determined by ultra-high performance liquid chromatography-tandem mass spectrometry. After filtration by filter membrane, HLB cartridge was selected to enrich and purify water samples. The analytes were separated on ACQUITY UPLC BEH C18 column and quantified by tandem mass spectrometry. The linear correlation coefficients of psychotropic substances were higher than 0.99 in the concentration range of 1.0—200 μg·L-1;the limits of detection were 1.05—9.90 ng·L-1; The recoveries were in the range of 65.69%—105.53% and the relative standard deviations (RSD) were less than 10%(n=6). The proposed method was rapid, stable and sensitive, which can meet the ultra-trace analysis requirements in the waters samples. The method was applied to the determination of the psychotropic substances in surface water from Taihu lake and the eleven kinds of substances could be detected with the range of 0.8—77.6 ng·L-1.
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    YAN X J, WANG J H, ZHU L S, et al. Effects of carbamazepine on the growth and the oxidative damage of Chlorella[J]. Journal of Agro-Environment Science, 2017, 36(4):643-650(in Chinese).

    [11] LIU J C, LU G H, XIE Z X, et al. Occurrence, bioaccumulation and risk assessment of lipophilic pharmaceutically active compounds in the downstream rivers of sewage treatment plants[J]. Science of the Total Environment, 2015, 511:54-62.
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    YAN X J, WANG J H, ZHU L S, et al. Effects of carbamazepine on the growth and the oxidative damage of Chlorella[J]. Journal of Agro-Environment Science, 2017, 36(4):643-650(in Chinese).

    [15] XIE Z X, LU G H, YAN Z, et al. Bioaccumulation and trophic transfer of pharmaceuticals in food webs from a large freshwater lake[J]. Environmental Pollution, 2017, 222:356-366.
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金苗, 杨慧婷, 陈辉辉, 沈幸, 王钰洋, 沈睿杰. 超高效液相色谱-串联质谱法同时测定环境水体中15种精神类药物[J]. 环境化学, 2020, (12): 3588-3592.
引用本文: 金苗, 杨慧婷, 陈辉辉, 沈幸, 王钰洋, 沈睿杰. 超高效液相色谱-串联质谱法同时测定环境水体中15种精神类药物[J]. 环境化学, 2020, (12): 3588-3592.
shu
JIN Miao, YANG Huiting, CHEN Huihui, SHEN Xing, WANG Yuyang, SHEN Ruijie. Simultaneous determination of 15 psychotropic substances in environmental water by ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry[J]. Environmental Chemistry, 2020, (12): 3588-3592.
Citation: JIN Miao, YANG Huiting, CHEN Huihui, SHEN Xing, WANG Yuyang, SHEN Ruijie. Simultaneous determination of 15 psychotropic substances in environmental water by ultra-high performance liquid chromatography-triple quadrupole tandem mass spectrometry[J]. Environmental Chemistry, 2020, (12): 3588-3592.
shu

超高效液相色谱-串联质谱法同时测定环境水体中15种精神类药物

    通讯作者: 陈辉辉, E-mail: hhchen@niglas.ac.cn ; 
  • 1. 中国科学院南京地理与湖泊研究所湖泊与环境国家重点实验室, 南京, 210008;
  • 2. 中国科学院大学, 北京, 100049;
  • 3. 内蒙古大学生态与环境学院, 内蒙古自治区环境污染控制与废物资源化重点实验室, 呼和浩特, 010021
基金项目:

国家自然科学基金（41907222）和中国科学院饮用水科学与技术重点实验室专项经费（20K05KLDWST）资助.

摘要: 采用固相萃取-超高效液相色谱串联质谱技术建立水中抗抑郁类、抗癫痫类、抗精神分裂类共15种精神类药物分析测定方法.水体样品经过Oasis HLB固相萃取柱进行富集后以ACQUITY UPLC BEH C18为分析柱，采用UPLC-MS/MS多反应监测离子（MRM）模式进行检测，同时外标法定量.结果表明，所建立的方法在1.0—200 μg·L-1范围内线性关系良好，相关系数R2均大于0.99；检出限为1.05—9.90 ng·L-1，加标回收率为65.69%—105.53%，相对标准偏差均小于10%（n=6），该法灵敏度高，分析速度快，满足痕量分析测试的要求，应用该方法测定了太湖水体中精神类药物的残留浓度水平，发现有11种物质可被不同程度检出，浓度范围为0.8—77.6 ng·L－1.

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