双酚A对新生儿的健康危害

王硕, 庄太凤. 双酚A对新生儿的健康危害[J]. 环境化学, 2020, (9): 2404-2412. doi: 10.7524/j.issn.0254-6108.2019070602
引用本文: 王硕, 庄太凤. 双酚A对新生儿的健康危害[J]. 环境化学, 2020, (9): 2404-2412. doi: 10.7524/j.issn.0254-6108.2019070602
WANG Shuo, ZHUANG Taifeng. Health effects of bisphenol A on newborns[J]. Environmental Chemistry, 2020, (9): 2404-2412. doi: 10.7524/j.issn.0254-6108.2019070602
Citation: WANG Shuo, ZHUANG Taifeng. Health effects of bisphenol A on newborns[J]. Environmental Chemistry, 2020, (9): 2404-2412. doi: 10.7524/j.issn.0254-6108.2019070602

双酚A对新生儿的健康危害

    通讯作者: 庄太凤, E-mail: wfs_1221@163.com
  • 基金项目:

    国家自然科学基金(21637004)资助.

Health effects of bisphenol A on newborns

    Corresponding author: ZHUANG Taifeng, wfs_1221@163.com
  • Fund Project: Supported by National Natural Science Foundation of China(21637004).
  • 摘要: 双酚A是一种内分泌干扰物,广泛应用于工业生产中.人类时常暴露于双酚类化合物中,研究表明孕母体内可以检测到双酚类化合物,意味着胎儿时期即开始接触双酚类化合物,除宫腔内暴露之外,双酚A还通过许多不同途径进入胎儿及新生儿体内.目前,双酚A对胎儿及新生儿造成的不同程度影响逐渐受到人们的关注.本文从新生儿出生结局、内分泌、神经系统及呼吸系统的4个方面探讨双酚A对新生儿短期和长期不良影响,帮助人们更全面深入地认识双酚类化合物对人类健康的危害.
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  • [1] HUANG R P, LIU Z H, YIN H, et al. Bisphenol A concentrations in human urine, human intakes across six continents, and annual trends of average intakes in adult and child populations worldwide:A thorough literature review[J]. Sci Total Environ, 2018,626:971-981.
    [2] VON GOETZ N, PIROW R, HART A, et al. Including non-dietary sources into an exposure assessment of the European Food Safety Authority:The challenge of multi-sector chemicals such as Bisphenol A[J]. Regul Toxicol Pharmacol, 2017,85:70-78.
    [3] ALI M, JAGHBIR M, SALAM M, et al. Testing baby bottles for the presence of residual and migrated bisphenol A[J]. Environ Monit Assess, 2018,191(1):7-10.
    [4] XUE J, WAN Y, KANNAN K. Occurrence of bisphenols, bisphenol A diglycidyl ethers (BADGEs), and novolac glycidyl ethers (NOGEs) in indoor air from Albany, New York, USA, and its implications for inhalation exposure[J]. Chemosphere, 2016,151:1-8.
    [5] LEE J, CHOI K, PARK J, et al. Bisphenol A distribution in serum, urine, placenta, breast milk, and umbilical cord serum in a birth panel of mother-neonate pairs[J]. Sci Total Environ, 2018,626:1494-1501.
    [6] PARK J H, HWANG M S, KO A, et al. Risk assessment based on urinary bisphenol A levels in the general Korean population[J]. Environ Res, 2016,150:606-615.
    [7] FU K Y, CHENG Y H, CHIO C P, et al. Probabilistic integrated risk assessment of human exposure risk to environmental bisphenol A pollution sources[J]. Environ Sci Pollut Res Int, 2016,23(19):19897-19910.
    [8] SIMONEAU C, VALZACCHI S, MORKUNAS V, et al. Comparison of migration from polyethersulphone and polycarbonate baby bottles[J]. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2011,28(12):1763-1768.
    [9] HARTLE J C, FOX M A, LAWRENCE R S. Probabilistic modeling of school meals for potential bisphenol A (BPA) exposure[J]. J Expo Sci Environ Epidemiol, 2016,26(3):315-323.
    [10] ERLER C, NOVAK J. Bisphenol a exposure:human risk and health policy[J]. J Pediatr Nurs, 2010,25(5):400-407.
    [11] PETEFFI G P, FLECK J D, KAEL I M, et al. Ecotoxicological risk assessment due to the presence of bisphenol A and caffeine in surface waters in the Sinos River Basin-Rio Grande do Sul-Brazil[J]. Braz J Biol, 2019,79(4):712-721.
    [12] WEE S Y, ARIS A Z, YUSOFF F M, et al. Occurrence and risk assessment of multiclass endocrine disrupting compounds in an urban tropical river and a proposed risk management and monitoring framework[J]. Sci Total Environ, 2019,671:431-442.
    [13] SI W, CAI Y, LIU J, et al. Investigating the role of colloids on the distribution of bisphenol analogues in surface water from an ecological demonstration area, China[J]. Sci Total Environ, 2019,673:699-707.
    [14] LV Y Z, YAO L, WANG L, et al. Bioaccumulation, metabolism, and risk assessment of phenolic endocrine disrupting chemicals in specific tissues of wild fish[J]. Chemosphere, 2019,226:607-615.
    [15] FAN J J, WANG S, TANG J P, et al. Bioaccumulation of endocrine disrupting compounds in fish with different feeding habits along the largest subtropical river, China[J]. Environ Pollut, 2019,247:999-1008.
    [16] CHAKRABORTY P, SAMPATH S, MUKHOPADHYAY M, et al. Baseline investigation on plasticizers, bisphenol A, polycyclic aromatic hydrocarbons and heavy metals in the surface soil of the informal electronic waste recycling workshops and nearby open dumpsites in Indian metropolitan cities[J]. Environ Pollut, 2019,248:1036-1045.
    [17] CARABAJAL M D, ARANCIBIA J A, ESCANDAR G M. Excitation-emission fluorescence-kinetic third-order/four-way data:Determination of bisphenol A and nonylphenol in food-contact plastics[J]. Talanta, 2019,197:348-355.
    [18] GEENS T, APELBAUM T Z, GOEYENS L, et al. Intake of bisphenol A from canned beverages and foods on the Belgian market[J]. Food Addit Contam Part A Chem Anal Control Expo Risk Assess, 2010,27(11):1627-1637.
    [19] LIU Y H, WANG P, LI J.[Simultaneous determination of nine phthalate esters and bisphenol A in cosmetics by ultra-high performance liquid chromatography] [J]. Journal of Hygiene Research, 2012,41(5):846-849.
    [20] NEGEV M, BERMAN T, REICHER S, et al. Concentrations of trace metals, phthalates, bisphenol A and flame-retardants in toys and other children's products in Israel[J]. Chemosphere, 2018,192:217-224.
    [21] FREIRE C, MOLINA-MOLINA J M, IRIBARNE-BURAN L M, et al. Concentrations of bisphenol A and parabens in socks for infants and young children in Spain and their hormone-like activities[J]. Environ Int, 2019,127:592-600.
    [22] MARTINEZ M A, CASTRO I, ROVIRA J, et al. Early-life intake of major trace elements, bisphenol A, tetrabromobisphenol A and fatty acids:Comparing human milk and commercial infant formulas[J]. Environ Res, 2019,169:246-255.
    [23] KARZI V, TZATZARAKIS M N, VAKONAKI E, et al. Biomonitoring of bisphenol A, triclosan and perfluorooctanoic acid in hair samples of children and adults[J]. J Appl Toxicol, 2018,38(8):1144-1152.
    [24] SHELBY M D. NTP-CERHR monograph on the potential human reproductive and developmental effects of bisphenol A[J]. NTP Cerhr Mon, 2008(22):1-64.
    [25] INOUE H, TSURUTA A, KUDO S, et al. Bisphenol a glucuronidation and excretion in liver of pregnant and nonpregnant female rats[J]. Drug Metab Dispos, 2005,33(1):55-59.
    [26] SAKAMOTO H, YOKOTA H, KIBE R, et al. Excretion of bisphenol A-glucuronide into the small intestine and deconjugation in the cecum of the rat[J]. Biochim Biophys Acta, 2002,1573(2):171-176.
    [27] THAYER K A, DOERGE D R, HUNT D, et al. Pharmacokinetics of bisphenol A in humans following a single oral administration[J]. Environ Int, 2015,83:107-115.
    [28] TROISI J, MIKELSON C, RICHARDS S, et al. Placental concentrations of bisphenol A and birth weight from births in the Southeastern U.S[J]. Placenta, 2014,35(11):947-952.
    [29] PINNEY S E, MESAROS C A, SNYDER N W, et al. Second trimester amniotic fluid bisphenol A concentration is associated with decreased birth weight in term infants[J]. Reprod Toxicol, 2017,67:1-9.
    [30] ZHANG H, ZHANG Y, LI J, et al. Occurrence and exposure assessment of bisphenol analogues in source water and drinking water in China[J]. Sci Total Environ, 2019,655:607-613.
    [31]
    [32] ZHOU X, PENG F, LUO Z, et al. Assessment of water contamination and health risk of endocrine disrupting chemicals in outdoor and indoor swimming pools[J]. Sci Total Environ, 2020,704:135277.
    [33] 梁志坚, 刘艳和, 刘贵明, 等. 塑料制品中双酚A高压液相色谱测定[J]. 中国公共卫生, 2005,21(9):1146-1147.

    LIANG Z,J, LIU Y H, LIU G M, et al. Determination of bisphenol A in plastic products by high pressure liquid chromatography[J]. Chinese Journal of Public Health, 2005, 21(9):1146-1147(in Chinese).

    [34] WANG L, ZHANG Y, LIU Y, et al. Widespread occurrence of bisphenol A in daily clothes and its high exposure risk in humans[J]. Environ Sci Technol, 2019,53(12):7095-7102.
    [35] RUSSO G, BARBATO F, GRUMETTO L. Monitoring of bisphenol A and bisphenol S in thermal paper receipts from the Italian market and estimated transdermal human intake:A pilot study[J]. Sci Total Environ, 2017,599/600:68-75.
    [36] 王肖, 王胜, 石梦蝶, 等. 武汉市双酚A污染纸币及票据的相关特征[J]. 公共卫生与预防医学, 2019,30(5):88-91.

    WANG X, WANG S, SHI M D, et al. Analysis of bissphenol A contamination of banknotes and bills in Wuhan[J]. Journal of Public Health and Preventive Medicine, 2019, 30(5):88-91(in Chinese).

    [37] SANTONICOLA S, FERRANTE M C, MURRU N, et al. Hot topic:Bisphenol A in cow milk and dietary exposure at the farm level[J]. J Dairy Sci, 2019,102(2):1007-1013.
    [38] 严燕, 黄蔷, 牟敬锋, 等. 桶装饮用水中双酚A的二次污染调查及暴露评估[J]. 实用预防医学, 2017,24(1):43-45.

    YAN Y, HUANG Q, MOU J F et al. Bisphenol A secondary pollution in barreled drinking water and its exposure assessment[J]. Practical Preventive Medicine, 2017, 24(1):43-45(in Chinese).

    [39] VEIGA-LOPEZ A, KANNAN K, LIAO C, et al. Gender-specific effects on gestational length and birth weight by early pregnancy BPA exposure[J]. J Clin Endocrinol Metab, 2015,100(11):E1394-E1403.
    [40] BELL E M, YEUNG E H, MA W, et al. Concentrations of endocrine disrupting chemicals in newborn blood spots and infant outcomes in the upstate KIDS study[J]. Environ Int, 2018,121(Pt 1):232-239.
    [41] SUN X, LI D, LIANG H, et al. Maternal exposure to bisphenol A and anogenital distance throughout infancy:A longitudinal study from Shanghai, China[J]. Environ Int, 2018,121(Pt 1):269-275.
    [42] SUNMAN B, YURDAKOK K, KOCER-GUMUSEL B, et al. Prenatal bisphenol a and phthalate exposure are risk factors for male reproductive system development and cord blood sex hormone levels[J]. Reprod Toxicol, 2019,87:146-155.
    [43] YEUNG E H, BELL E M, SUNDARAM R, et al. Examining endocrine disruptors measured in newborn dried blood spots and early childhood growth in a prospective cohort[J]. Obesity (Silver Spring), 2019,27(1):145-151.
    [44] SANLIDAG B, DALKAN C, YETKIN O, et al. Evaluation of dose dependent maternal exposure to bisphenol a on thyroid functions in newborns[J]. J Clin Med, 2018,7(6).E119-E126.
    [45] MINATOYA M, SASAKI S, ARAKI A, et al. Cord blood bisphenol a levels and reproductive and thyroid hormone levels of neonates:The hokkaido study on environment and children's health[J]. Epidemiology, 2017,28 Suppl 1:S3-S9.
    [46] MAMMADOW E, UNCU M, DALKAN C. High prenatal exposure to bisphenol a reduces anogenital distance in healthy male newborns[J]. J Clin Res Pediatr Endocrinol, 2018,10(1):25-29.
    [47] LIAO S L, TSAI M H, LAI S H, et al. Prenatal exposure to bisphenol-A is associated with Toll-like receptor-induced cytokine suppression in neonates[J]. Pediatr Res, 2016,79(3):438-444.
    [48] LEE Y M, HONG Y C, HA M, et al. Prenatal Bisphenol-A exposure affects fetal length growth by maternal glutathione transferase polymorphisms, and neonatal exposure affects child volume growth by sex:From multiregional prospective birth cohort MOCEH study[J]. Sci Total Environ, 2018,612:1433-1441.
    [49] WANG H, LIU L, WANG J, et al. Urinary sexual steroids associated with bisphenol A (BPA) exposure in the early infant stage:Preliminary results from a Daishan birth cohort[J]. Sci Total Environ, 2017,601/602:1733-1742.
    [50] GHASSABIAN A, BELL E M, MA W L, et al. Concentrations of perfluoroalkyl substances and bisphenol A in newborn dried blood spots and the association with child behavior[J]. Environ Pollut, 2018,243(Pt B):1629-1636.
    [51] AKER A M, FERGUSON K K, ROSARIO Z Y, et al. The associations between prenatal exposure to triclocarban, phenols and parabens with gestational age and birth weight in northern Puerto Rico[J]. Environ Res, 2019,169:41-51.
    [52] LEE B E, PARK H, HONG Y C, et al. Prenatal bisphenol A and birth outcomes:MOCEH (Mothers and Children's Environmental Health) study[J]. Int J Hyg Environ Health, 2014,217(2/3):328-334.
    [53] HUO W, XIA W, WAN Y, et al. Maternal urinary bisphenol A levels and infant low birth weight:A nested case-control study of the health baby cohort in China[J]. Environ Int, 2015,85:96-103.
    [54] DING G, WANG C, VINTURACHE A, et al. Prenatal low-level phenol exposures and birth outcomes in China[J]. Sci Total Environ, 2017,607/608:1400-1407.
    [55] CASAS M, VALVI D, BALLESTEROS-GOMEZ A, et al. Exposure to bisphenol a and phthalates during pregnancy and ultrasound measures of fetal growth in the INMA-Sabadell cohort[J]. Environ Health Perspect, 2016,124(4):521-528.
    [56] LESTER F, ARBUCKLE T E, PENG Y, et al. Impact of exposure to phenols during early pregnancy on birth weight in two Canadian cohort studies subject to measurement errors[J]. Environ Int, 2018,120:231-237.
    [57] YANG T C, PETERSON K E, MEEKER J D, et al. Exposure to bisphenol A and phthalates metabolites in the third trimester of pregnancy and BMI trajectories[J]. Pediatr Obes, 2018,13(9):550-557.
    [58] BARRETT E S, SATHYANARAYANA S, MBOWE O, et al. First-trimester urinary bisphenol A concentration in relation to anogenital distance, an androgen-sensitive measure of reproductive development, in infant girls[J]. Environ Health Perspect, 2017,125(7):77008.
    [59] ROMANO M E, WEBSTER G M, VUONG A M, et al. Gestational urinary bisphenol A and maternal and newborn thyroid hormone concentrations:the HOME study[J]. Environ Res, 2015,138:453-460.
    [60] SPANIER A J, KAHN R S, KUNSELMAN A R, et al. Prenatal exposure to bisphenol A and child wheeze from birth to 3 years of age[J]. Environ Health Perspect, 2012,120(6):916-920.
    [61] BERGER K, ESKENAZI B, KOGUT K, et al. Association of prenatal urinary concentrations of phthalates and bisphenol a and pubertal timing in boys and girls[J]. Environ Health Perspect, 2018,126(9):97004.
    [62] WANG Z, LIANG H, TU X, et al. Bisphenol A and pubertal height growth in school-aged children[J]. J Expo Sci Environ Epidemiol, 2019,29(1):109-117.
    [63] DE FILIPPIS E, LI T, ROSEN E D. Exposure of adipocytes to bisphenol-A in vitro interferes with insulin action without enhancing adipogenesis[J]. Plos One, 2018,13(8):e201122.
    [64] AMIN M M, EBRAHIM K, HASHEMI M, et al. Association of exposure to bisphenol A with obesity and cardiometabolic risk factors in children and adolescents[J]. Int J Environ Health Res, 2019,29(1):94-106.
    [65] 赵金华, 洪菲, 陆生丽, 等. 南通市学龄儿童双酚A暴露现状及其与肥胖的关系[J]. 海南医学, 2018,29(16):2263-2265.

    ZHAO J H, HONG F, LU S L, et al. Status of bisphenol A exposure and its relationship with obesity in school-age children in Nantong city[J]. Hainan Medical Journal, 2018, 29(16):2263-2265(in Chinese).

    [66] DESAI M, FERRINI M G, JELLYMAN J K, et al. In vivo and in vitro bisphenol A exposure effects on adiposity[J]. J Dev Orig Health Dis, 2018,9(6):678-687.
    [67] DONG H, YAO X, LIU S, et al. Non-cytotoxic nanomolar concentrations of bisphenol A induce human mesenchymal stem cell adipogenesis and osteogenesis[J]. Ecotoxicol Environ Saf, 2018,164:448-454.
    [68] REDDIVARI L, VEERAMACHANEI D, WALTERS W A, et al. Perinatal bisphenol A exposure induces chronic inflammation in rabbit offspring via modulation of gut bacteria and their metabolites[J]. Msystems, 2017,2(5):e00093-17.
    [69] AUNG M T, JOHNS L E, FERGUSON K K, et al. Thyroid hormone parameters during pregnancy in relation to urinary bisphenol A concentrations:A repeated measures study[J]. Environ Int, 2017,104:33-40.
    [70] AHMED R G, WALAA G H, ASMAA F S. Suppressive effects of neonatal bisphenol A on the neuroendocrine system[J]. Toxicol Ind Health, 2018,34(6):397-407.
    [71] FERNANDEZ M O, BOURGUIGNON N S, AROCENA P, et al. Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats[J]. Toxicol Lett, 2018,285:81-86.
    [72] CHU P W, YANG Z J, HUANG H H, et al. Low-dose bisphenol A activates the ERK signaling pathway and attenuates steroidogenic gene expression in human placental cells[J]. Biol Reprod, 2018,98(2):250-258.
    [73] ELADAK S, MOISON D, GUERQUIN M J, et al. Effects of environmental Bisphenol A exposures on germ cell development and Leydig cell function in the human fetal testis[J]. Plos One, 2018,13(1):e191934.
    [74] XIE M, BU P, LI F, et al. Neonatal bisphenol A exposure induces meiotic arrest and apoptosis of spermatogenic cells[J]. Oncotarget, 2016,7(9):10606-10615.
    [75] 郑艳敏, 王燕, 赵静, 等. 血清双酚A含量与复发性流产的1:2病例对照研究[J]. 中华流行病学杂志, 2012,33(8):841-845.

    ZHENG Y M, WANG Y, ZHAO J, et al. Association between serum bisphenol-A and recurrent spontaneous abortion:A 1:2 case-control study, China[J]. Chinese Journal of Epidemiology, 2012, 33(8):841-845(in Chinese).

    [76] 王明远, 陈诚, 潘峰, 等. 双酚A与不明原因复发性流产发生关系的病例对照研究[J]. 第三军医大学学报, 2017,39(6):579-583.

    WANG M Y, CHEN C, PAN F, et al. Association of bisphenol A with unexplained recurrent spontaneous abortion:a case-control research[J]. Journal of third military medical university, 2017, 39(6):579-583(in Chinese).

    [77] CHAVARRO J E, MINGUEZ-ALARCON L, CHIU Y H, et al. Soy intake modifies the relation between urinary bisphenol A concentrations and pregnancy outcomes among women undergoing assisted reproduction[J]. J Clin Endocrinol Metab, 2016,101(3):1082-1090.
    [78] ULLAH A, PIRZADA M, JAHAN S, et al. Impact of low-dose chronic exposure to bisphenol A and its analogue bisphenol B, bisphenol F and bisphenol S on hypothalamo-pituitary-testicular activities in adult rats:A focus on the possible hormonal mode of action[J]. Food Chem Toxicol, 2018,121:24-36.
    [79] LIU C, XU X, ZHANG Y, et al. Associations between maternal phenolic exposure and cord sex hormones in male newborns[J]. Hum Reprod, 2016,31(3):648-656.
    [80] GANESAN S, KEATING A F. Bisphenol A-induced ovotoxicity involves DNA damage induction to which the ovary mounts a protective response indicated by increased expression of proteins involved in DNA repair and xenobiotic biotransformation[J]. Toxicol Sci, 2016,152(1):169-180.
    [81] FANG F, GAO Y, WANG T, et al. Insulin signaling disruption in male mice due to perinatal bisphenol A exposure:Role of insulin signaling in the brain[J]. Toxicol Lett, 2016,245:59-67.
    [82] WATKINS D J, PETERSON K E, FERGUSON K K, et al. Relating phthalate and BPA exposure to metabolism in peripubescence:The role of exposure timing, sex, and puberty[J]. J Clin Endocrinol Metab, 2016,101(1):79-88.
    [83] QIU W, ZHAO Y, YANG M, et al. Actions of bisphenol A and bisphenol S on the reproductive neuroendocrine system during early development in zebrafish[J]. Endocrinology, 2016,157(2):636-647.
    [84] DESAI M, FERRINI M G, HAN G, et al. In vivo maternal and in vitro BPA exposure effects on hypothalamic neurogenesis and appetite regulators[J]. Environ Res, 2018,164:45-52.
    [85] WISE L M, SADOWSKI R N, KIM T, et al. Long-term effects of adolescent exposure to bisphenol A on neuron and glia number in the rat prefrontal cortex:Differences between the sexes and cell type[J]. Neurotoxicology, 2016,53:186-192.
    [86] LIU Z H, DING J J, YANG Q Q, et al. Early developmental bisphenol-A exposure sex-independently impairs spatial memory by remodeling hippocampal dendritic architecture and synaptic transmission in rats[J]. Sci Rep, 2016,6:32492.
    [87] ARAMBULA S E, BELCHER S M, PLANCHART A, et al. Impact of low dose oral exposure to bisphenol A (BPA) on the neonatal rat hypothalamic and hippocampal transcriptome:A clarity-BPA consortium study[J]. Endocrinology, 2016,157(10):3856-3872.
    [88] FUJIWARA Y, MIYAZAKI W, KOIBUCHI N, et al. The effects of low-dose bisphenol A and bisphenol F on neural differentiation of a fetal brain-derived neural progenitor cell line[J]. Front Endocrinol (Lausanne), 2018,9:24.
    [89] MAHEMUTI L, CHEN Q, COUGHLAN M C, et al. Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts[J]. Arch Toxicol, 2018,92(4):1453-1469.
    [90] KOIKE E, YANAGISAWA R, WIN-SHWE T T, et al. Exposure to low-dose bisphenol A during the juvenile period of development disrupts the immune system and aggravates allergic airway inflammation in mice[J]. Int J Immunopathol Pharmacol, 2018,32:1680012145.
    [91] HE M, ICHINOSE T, YOSHIDA S, et al. Exposure to bisphenol A enhanced lung eosinophilia in adult male mice[J]. Allergy Asthma Clin Immunol, 2016,12:16-24.
    [92] SPANIER A J, KAHN R S, KUNSELMAN A R, et al. Bisphenol a exposure and the development of wheeze and lung function in children through age 5 years[J]. Jama Pediatr, 2014,168(12):1131-1137.
    [93] GASCON M, CASAS M, MORALES E, et al. Prenatal exposure to bisphenol A and phthalates and childhood respiratory tract infections and allergy[J]. J Allergy Clin Immunol, 2015,135(2):370-378.
    [94] ROY A, BAUER S M, LAWRENCE B P. Developmental exposure to bisphenol A modulates innate but not adaptive immune responses to influenza A virus infection[J]. Plos One, 2012,7(6):e38448.
    [95] PETZOLD S, AVERBECK M, SIMON J C, et al. Lifetime-dependent effects of bisphenol A on asthma development in an experimental mouse model[J]. Plos One, 2014,9(6):e100468.
    [96] NAKAJIMA Y, GOLDBLUM R M, MODORO-HORIUTI T. Fetal exposure to bisphenol A as a risk factor for the development of childhood asthma:An animal model study[J]. Environ Health, 2012,11:8-14.
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  • 收稿日期:  2019-07-06
王硕, 庄太凤. 双酚A对新生儿的健康危害[J]. 环境化学, 2020, (9): 2404-2412. doi: 10.7524/j.issn.0254-6108.2019070602
引用本文: 王硕, 庄太凤. 双酚A对新生儿的健康危害[J]. 环境化学, 2020, (9): 2404-2412. doi: 10.7524/j.issn.0254-6108.2019070602
WANG Shuo, ZHUANG Taifeng. Health effects of bisphenol A on newborns[J]. Environmental Chemistry, 2020, (9): 2404-2412. doi: 10.7524/j.issn.0254-6108.2019070602
Citation: WANG Shuo, ZHUANG Taifeng. Health effects of bisphenol A on newborns[J]. Environmental Chemistry, 2020, (9): 2404-2412. doi: 10.7524/j.issn.0254-6108.2019070602

双酚A对新生儿的健康危害

    通讯作者: 庄太凤, E-mail: wfs_1221@163.com
  • 首都医科大学附属北京妇产医院, 新生儿科, 北京, 100026
基金项目:

国家自然科学基金(21637004)资助.

摘要: 双酚A是一种内分泌干扰物,广泛应用于工业生产中.人类时常暴露于双酚类化合物中,研究表明孕母体内可以检测到双酚类化合物,意味着胎儿时期即开始接触双酚类化合物,除宫腔内暴露之外,双酚A还通过许多不同途径进入胎儿及新生儿体内.目前,双酚A对胎儿及新生儿造成的不同程度影响逐渐受到人们的关注.本文从新生儿出生结局、内分泌、神经系统及呼吸系统的4个方面探讨双酚A对新生儿短期和长期不良影响,帮助人们更全面深入地认识双酚类化合物对人类健康的危害.

English Abstract

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