羟基多溴联苯醚(3'-OH-BDE-7)的大鼠体外肝代谢研究

赖永权, 陈学国, 蔡宗苇. 羟基多溴联苯醚(3'-OH-BDE-7)的大鼠体外肝代谢研究[J]. 环境化学, 2011, 30(1): 346-350.
引用本文: 赖永权, 陈学国, 蔡宗苇. 羟基多溴联苯醚(3'-OH-BDE-7)的大鼠体外肝代谢研究[J]. 环境化学, 2011, 30(1): 346-350.
LAI Yongquan, CHEN Xueguo, CAI Zongwei. IN VITRO METABOLISM STUDY OF 3'-OH-2,4-diBDE-7 IN RAT LIVER S9 FRACTION[J]. Environmental Chemistry, 2011, 30(1): 346-350.
Citation: LAI Yongquan, CHEN Xueguo, CAI Zongwei. IN VITRO METABOLISM STUDY OF 3'-OH-2,4-diBDE-7 IN RAT LIVER S9 FRACTION[J]. Environmental Chemistry, 2011, 30(1): 346-350.

羟基多溴联苯醚(3'-OH-BDE-7)的大鼠体外肝代谢研究

IN VITRO METABOLISM STUDY OF 3'-OH-2,4-diBDE-7 IN RAT LIVER S9 FRACTION

  • 摘要: 本文利用液相色谱-质谱联用技术,建立了羟基多溴联苯醚3'-OH-BDE-7在S.D.大鼠肝匀浆中的体外代谢研究方法.实验结果表明,3'-OH-BDE-7的主要代谢产物为2, 4-二溴苯酚和二羟基多溴联苯醚(diOH-PBDEs),并且其在温孵30min,时代谢转化率为90%.3'-OH-BDE-7的代谢研究为其它羟基多溴联苯醚的相应研究提供了信息,其代谢行为也对更好地理解PBDEs和OH-PBDEs的毒理和动力学具有一定意义.
  • 加载中
  • [1] Meerts I A T M, Letcher R J, Hoving S,et al. In vitro estrogenicity of polybrominated diphenyl ethers, hydroxylated PBDEs, and polybrominated bisphenol A compounds[J]. Environmental Health Perspectives, 2001, 109 (4):399-407
    [2] Qiu X H, Mercado-Feliciano M, Bigsby R M, et al. Measurement of polybrominated diphenyl ethers and metabolites in mouse plasma after exposure to a commercial pentabromodiphenyl ether mixture[J]. Environmental Health Perspectives, 2007, 115 (7):1052-1058
    [3] Marsh G, Athanasiadou M, Bergman A, et al. Identification of hydroxylated and methoxylated polybrominated diphenyl ethers in Baltic Sea salmon (Salmo salar) blood[J]. Environmental Science & Technology, 2004, 38 (1):10-18
    [4] Malmvarn A, Marsh G, Kautsky L, et al. Hydroxylated and methoxylated brominated diphenyl ethers in the red algae Ceramium tenuicorne and blue mussels from the Baltic Sea[J]. Environmental Science & Technology, 2005, 39 (9):2990-2997
    [5] Malmberg T, Athanasiadou M, Marsh G, et al. Identification of hydroxylated polybrominated diphenyl ether metabolites in blood plasma from polybrominated diphenyl ether exposed rats[J]. Environmental Science & Technology, 2005, 39 (14):5342-5348
    [6] Qiu X H, Mercado-Feliciano M, Bigsby R M, et al. Measurement of polybrominated diphenyl ethers and metabolites in mouse plasma after exposure to a commercial pentabromodiphenyl ether mixture[J]. Environmental Health Perspectives, 2007, 115 (7):1052-1058
    [7] Athanasiadou M, Cuadra S N, Marsh G, et al. Polybrominated diphenyl ethers (PBDEs) and bioaccumulative hydroxylated PBDE metabolites in young humans from Managua, Nicaragua[J]. Environmental Health Perspectives, 2008, 116 (3):400-408
    [8] Bowden B F, Towerzey L, Junk P C. A new brominated diphenyl ether from the marine sponge Dysidea herbacea[J]. Australian Journal of Chemistry, 2000, 53 (4):299-301
    [9] Fu X O, Schmitz E J, Govindan M, et al. Enzyme-inhibitors-new and known polybrominated phenols and diphenyl ethers from 4 indo-pacific dysidea sponges[J]. Journal of Natural Products-Lloydia, 1995, 58 (9):1384-1391
    [10] Dingemans M M L, de Groot A, van Kleef R G D M, et al. Hydroxylation increases the neurotoxic potential of BDE-47 to affect exocytosis and calcium homeostasis in PC12 cells[J]. Environmental Health Perspectives, 2008, 116 (5):637-643
    [11] Qiu X H, Bigsby R M, Hites R A. Hydroxylated metabolites of polybrominated diphenyl ethers in human blood samples from the united states[J]. Environmental Health Perspectives, 2009, 117 (1):93-98
    [12] Marsh G, Athanasiadou M, Athanassiadis I, et al. Identification of hydroxylated metabolites in 2,2',4,4'-tetrabromodiphenyl ether exposed rats[J]. Chemosphere, 2006, 63 (4):690-697
    [13] Hakk H, Huwe J, Low M, et al. Tissue disposition, excretion and metabolism of 2,2',4,4',6-pentabromodiphenyl ether (BDE-100) in male Sprague-Dawley rats[J]. Xenobiotica, 2006, 36 (1):79-94
    [14] Lupton S J, McGarrigle B P, Olson J R, et al. Human liver microsome-mediated metabolism of brominated diphenyl ethers 47, 99, and 153 and identification of their major metabolites[J]. Chemical Research in Toxicology, 2009, 22 (11):1802-1809
    [15] Yu Z Q, Zheng K W, Ren G F, et al. Identification of hydroxylated octa- and nona-bromodiphenyl ethers in human serum from electronic waste dismantling workers[J]. Environmental Science & Technology, 2010, 44 (10):3979-3985
    [16] Bolton J L, Trush M A, Penning T M, et al. Role of quinones in toxicology[J]. Chemical Research in Toxicology, 2000, 13 (3):135-160
  • 加载中
计量
  • 文章访问数:  814
  • HTML全文浏览数:  814
  • PDF下载数:  399
  • 施引文献:  0
出版历程
  • 收稿日期:  2010-08-25
  • 刊出日期:  2011-01-15
赖永权, 陈学国, 蔡宗苇. 羟基多溴联苯醚(3'-OH-BDE-7)的大鼠体外肝代谢研究[J]. 环境化学, 2011, 30(1): 346-350.
引用本文: 赖永权, 陈学国, 蔡宗苇. 羟基多溴联苯醚(3'-OH-BDE-7)的大鼠体外肝代谢研究[J]. 环境化学, 2011, 30(1): 346-350.
LAI Yongquan, CHEN Xueguo, CAI Zongwei. IN VITRO METABOLISM STUDY OF 3'-OH-2,4-diBDE-7 IN RAT LIVER S9 FRACTION[J]. Environmental Chemistry, 2011, 30(1): 346-350.
Citation: LAI Yongquan, CHEN Xueguo, CAI Zongwei. IN VITRO METABOLISM STUDY OF 3'-OH-2,4-diBDE-7 IN RAT LIVER S9 FRACTION[J]. Environmental Chemistry, 2011, 30(1): 346-350.

羟基多溴联苯醚(3'-OH-BDE-7)的大鼠体外肝代谢研究

  • 1.  香港浸会大学化学系, 香港特别行政区;
  • 2.  中国刑事警察学院法医系, 沈阳, 110854

摘要: 本文利用液相色谱-质谱联用技术,建立了羟基多溴联苯醚3'-OH-BDE-7在S.D.大鼠肝匀浆中的体外代谢研究方法.实验结果表明,3'-OH-BDE-7的主要代谢产物为2, 4-二溴苯酚和二羟基多溴联苯醚(diOH-PBDEs),并且其在温孵30min,时代谢转化率为90%.3'-OH-BDE-7的代谢研究为其它羟基多溴联苯醚的相应研究提供了信息,其代谢行为也对更好地理解PBDEs和OH-PBDEs的毒理和动力学具有一定意义.

English Abstract

参考文献 (16)

返回顶部

目录

/

返回文章
返回