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液相色谱-串联质谱法检测猪肉中肾上腺素及其代谢物残留

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李双, 刘忠义, 李露青, 周红玲, 徐旭文, 陈树兵. 液相色谱-串联质谱法检测猪肉中肾上腺素及其代谢物残留[J]. 环境化学, 2019, 38(3): 701-703.
引用本文: 李双, 刘忠义, 李露青, 周红玲, 徐旭文, 陈树兵. 液相色谱-串联质谱法检测猪肉中肾上腺素及其代谢物残留[J]. 环境化学, 2019, 38(3): 701-703.
shu
LI Shuang, LIU Zhongyi, LI Luqing, ZHOU Hongling, XU Xuwen, CHEN Shubing. Analysis of adrenaline drugs in pork by high performance liquid chromatography-tandem mass spectrometry[J]. Environmental Chemistry, 2019, 38(3): 701-703.
Citation: LI Shuang, LIU Zhongyi, LI Luqing, ZHOU Hongling, XU Xuwen, CHEN Shubing. Analysis of adrenaline drugs in pork by high performance liquid chromatography-tandem mass spectrometry[J]. Environmental Chemistry, 2019, 38(3): 701-703.
shu

液相色谱-串联质谱法检测猪肉中肾上腺素及其代谢物残留

  • 1.

    宁波出入境检验检疫局检验检疫技术中心, 宁波, 315211;

  • 2.

    宁波大学应用海洋生物技术教育部重点实验室, 宁波, 315211

  • 基金项目:

    浙江省基础公益研究计划（LGN18B050002）资助.

Analysis of adrenaline drugs in pork by high performance liquid chromatography-tandem mass spectrometry

  • 1.

    Ningbo Entry-Exit Inspection and Quarantine Bureau Technology Center of P. R. China, Ningbo, 315211, China;

  • 2.

    Key Laboratory of Applied Marine Biotechnology, Ningbo University, Chinese Ministry of Education, Ningbo, 315211, China

  • Fund Project: Supported by Basic Public interest Research Project of Zhejiang Province (LGN18B050002)

  • 摘要: 针对猪肉中新兴的肾上腺素及其代谢物3，4-二羟基扁桃酸、4-羟基-3-甲氧基-扁桃酸，基于"肾上腺素作用翻转"机理同步添加的异丙嗪，建立了超高效液相色谱-串联质谱检测方法.4种物质线性良好，相关系数均大于0.999；猪肉基质的定量限（LOQ，S/N=10）依次为25、100、5、0.1 μg·kg-1，精密度（RSD）均小于10%，平均回收率在78.3%-92.5%.
    Abstract: A simultaneous multi-class analysis method for new adrenaline drugs and its metabolites (3,4-dihydroxymandelic acid and vanillylmandelic acid), and promethazine based on the mechanism of "epinephrine reversal" in pork by high performance liquid chromatography-tandem mass spectrometry was established.In the corresponding concentration range, 4 targets had good linear relationships with correlation coefficients more than 0.999. The limits of quantification (LOQs) were 25,100, 5, 0.1 μg·kg-1 in pork, respectively. The average recoveries were 78.3%-92.5% and relative standard deviations were below 10%.
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  • 刊出日期:  2019-03-15
李双, 刘忠义, 李露青, 周红玲, 徐旭文, 陈树兵. 液相色谱-串联质谱法检测猪肉中肾上腺素及其代谢物残留[J]. 环境化学, 2019, 38(3): 701-703.
引用本文: 李双, 刘忠义, 李露青, 周红玲, 徐旭文, 陈树兵. 液相色谱-串联质谱法检测猪肉中肾上腺素及其代谢物残留[J]. 环境化学, 2019, 38(3): 701-703.
shu
LI Shuang, LIU Zhongyi, LI Luqing, ZHOU Hongling, XU Xuwen, CHEN Shubing. Analysis of adrenaline drugs in pork by high performance liquid chromatography-tandem mass spectrometry[J]. Environmental Chemistry, 2019, 38(3): 701-703.
Citation: LI Shuang, LIU Zhongyi, LI Luqing, ZHOU Hongling, XU Xuwen, CHEN Shubing. Analysis of adrenaline drugs in pork by high performance liquid chromatography-tandem mass spectrometry[J]. Environmental Chemistry, 2019, 38(3): 701-703.
shu

液相色谱-串联质谱法检测猪肉中肾上腺素及其代谢物残留

  • 1.  宁波出入境检验检疫局检验检疫技术中心, 宁波, 315211;
  • 2.  宁波大学应用海洋生物技术教育部重点实验室, 宁波, 315211
基金项目:

浙江省基础公益研究计划（LGN18B050002）资助.

摘要: 针对猪肉中新兴的肾上腺素及其代谢物3，4-二羟基扁桃酸、4-羟基-3-甲氧基-扁桃酸，基于"肾上腺素作用翻转"机理同步添加的异丙嗪，建立了超高效液相色谱-串联质谱检测方法.4种物质线性良好，相关系数均大于0.999；猪肉基质的定量限（LOQ，S/N=10）依次为25、100、5、0.1 μg·kg-1，精密度（RSD）均小于10%，平均回收率在78.3%-92.5%.

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