环境微生物耐药阻控研究进展
Progress on Antibiotic Resistance Control of Environmental Microorganisms
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摘要: 世界卫生组织将微生物耐药视为21世纪全球健康的主要挑战之一。根据One Health观念，微生物耐药可以跨越生态边界在环境、动物、人体中传播，给生态安全和人类健康带来威胁。耐药菌株的快速传播和演变使得传统抗生素治疗效果逐渐减弱。因此，需要研究环境中耐药现状，提出缓解环境微生物耐药的策略。在该综述中，我们重点介绍缓解微生物耐药的策略，具体包括化学阻控、生物阻控、CRISPR-Cas系统应用和群落调节等手段，并对这些策略的优缺点进行了评述。这些策略有望遏制全球耐药的恶化及蔓延。Abstract: Antibiotic resistance has been identified by the World Health Organization as one of the major global health challenges of the 21st Century. From a One Health perspective, the spread of antimicrobial resistance across ecological boundaries poses significant threats to human health and ecosystems. The efficacy of traditional antibiotics has been diminished by the rapid dissemination and evolution of resistant strains. Therefore, it is imperative that the current status of environmental antibiotic resistance be assessed and strategies to mitigate it be developed. In this review, several strategies to address antimicrobial resistance are examined, including chemical resistance control, biological resistance control, CRISPR-Cas system application, and community regulation. The advantages and disadvantages of each approach are evaluated. It is expected that these strategies will effectively curb the deterioration and spread of global drug resistance.
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