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[C14 min]BF4对大鼠免疫功能的影响

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束曼玉, 徐红梅, 谭鹏振, 葛月月, 田杏杏. [C14 min]BF4对大鼠免疫功能的影响[J]. 生态毒理学报, 2024, 19(5): 213-220. doi: 10.7524/AJE.1673-5897.20240423001
引用本文: 束曼玉, 徐红梅, 谭鹏振, 葛月月, 田杏杏. [C14 min]BF4对大鼠免疫功能的影响[J]. 生态毒理学报, 2024, 19(5): 213-220. doi: 10.7524/AJE.1673-5897.20240423001
shu
Shu Manyu, Xu Hongmei, Tan Pengzhen, Ge Yueyue, Tian Xingxing. Effect of [C14 min]BF4 on Immune Function in Rats[J]. Asian journal of ecotoxicology, 2024, 19(5): 213-220. doi: 10.7524/AJE.1673-5897.20240423001
Citation: Shu Manyu, Xu Hongmei, Tan Pengzhen, Ge Yueyue, Tian Xingxing. Effect of [C14 min]BF4 on Immune Function in Rats[J]. Asian journal of ecotoxicology, 2024, 19(5): 213-220. doi: 10.7524/AJE.1673-5897.20240423001
shu

[C14 min]BF4对大鼠免疫功能的影响

  • 合肥工业大学食品与生物工程学院, 合肥 230601

    • 作者简介: 束曼玉(1999-),女,硕士,研究方向为离子液体毒性,E-mail:1546405446@qq.com
    通讯作者: 徐红梅,E-mail:xuhongmei@hfut.edu.cn; 

  • 中图分类号: X171.5

Effect of [C14 min]BF4 on Immune Function in Rats

  • School of Food and Bioengineering, Hefei University of Technology, Hefei 230601, China

    • Corresponding author: Xu Hongmei, xuhongmei@hfut.edu.cn ; 

  • 摘要: 为了研究离子液体四氟硼酸化-1-十四烷基-3-甲基咪唑盐([C14 min]BF4)对大鼠的免疫毒性，实验设立3个染毒组(12.5、25和50 mg·kg-1)、1个染毒恢复组(50 mg·kg-1)和空白对照组，考察SD大鼠经口染毒90 d后，[C14 min]BF4对大鼠体质量变化、脏器系数及免疫功能的影响。结果显示：[C14 min]BF4染毒后，大鼠体质量和脏器指数均发生改变；其脾脏B淋巴细胞亚群及其增殖能力、自然杀伤细胞(natural killer cell, NK细胞)活性以及血清中白介素-4(interleukin-4, IL-4)和补体蛋白C3含量均随染毒剂量的增加而降低；而血清中γ-干扰素(interferon-γ, IFN-γ)的水平则随[C14 min]BF4剂量的增加而升高。停止染毒30 d后，部分指标略有改善。实验表明[C14 min]BF4长期染毒可引起大鼠免疫功能紊乱，产生免疫毒性。
    Abstract: To study the immunotoxicity of the ionic liquid tetrafluoroborated -1-tetracyl-3-methylimidazole salt ([C14 min]BF4) on rats, the experiment established three dosing groups (12.5, 25 and 50 mg·kg-1), one dosing recovery group (50 mg·kg-1), and a blank control group. The effects of [C14 min]BF4 on body weight changes, organ coefficients, and immune function in SD rats were observed after oral administration for 90 days. The results showed that after [C14 min]BF4 exposure, the body weight and organ indices of the rats changed. The spleen B lymphocyte subsets and their proliferative capacity, natural killer (NK) cell activity, and the levels of interleukin-4 (IL-4) and complement protein C3 in serum decreased as the exposure doses increased; while the level of interferon-γ (IFN-γ) in serum increased with increasing doses of [C14 min]BF4. After a 30-day recovery period following exposure cessation, some indicators showed slight improvements. The experiment indicates that long-term exposure to [C14 min]BF4 can cause immune dysfunction in rats and produce immunotoxicity.
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  • 收稿日期:  2024-04-23
束曼玉, 徐红梅, 谭鹏振, 葛月月, 田杏杏. [C14 min]BF4对大鼠免疫功能的影响[J]. 生态毒理学报, 2024, 19(5): 213-220. doi: 10.7524/AJE.1673-5897.20240423001
引用本文: 束曼玉, 徐红梅, 谭鹏振, 葛月月, 田杏杏. [C14 min]BF4对大鼠免疫功能的影响[J]. 生态毒理学报, 2024, 19(5): 213-220. doi: 10.7524/AJE.1673-5897.20240423001
shu
Shu Manyu, Xu Hongmei, Tan Pengzhen, Ge Yueyue, Tian Xingxing. Effect of [C14 min]BF4 on Immune Function in Rats[J]. Asian journal of ecotoxicology, 2024, 19(5): 213-220. doi: 10.7524/AJE.1673-5897.20240423001
Citation: Shu Manyu, Xu Hongmei, Tan Pengzhen, Ge Yueyue, Tian Xingxing. Effect of [C14 min]BF4 on Immune Function in Rats[J]. Asian journal of ecotoxicology, 2024, 19(5): 213-220. doi: 10.7524/AJE.1673-5897.20240423001
shu

[C14 min]BF4对大鼠免疫功能的影响

    通讯作者: 徐红梅,E-mail:xuhongmei@hfut.edu.cn; 
    作者简介: 束曼玉(1999-),女,硕士,研究方向为离子液体毒性,E-mail:1546405446@qq.com
  • 合肥工业大学食品与生物工程学院, 合肥 230601
  • 收稿日期:  2024-04-23

摘要: 为了研究离子液体四氟硼酸化-1-十四烷基-3-甲基咪唑盐([C14 min]BF4)对大鼠的免疫毒性，实验设立3个染毒组(12.5、25和50 mg·kg-1)、1个染毒恢复组(50 mg·kg-1)和空白对照组，考察SD大鼠经口染毒90 d后，[C14 min]BF4对大鼠体质量变化、脏器系数及免疫功能的影响。结果显示：[C14 min]BF4染毒后，大鼠体质量和脏器指数均发生改变；其脾脏B淋巴细胞亚群及其增殖能力、自然杀伤细胞(natural killer cell, NK细胞)活性以及血清中白介素-4(interleukin-4, IL-4)和补体蛋白C3含量均随染毒剂量的增加而降低；而血清中γ-干扰素(interferon-γ, IFN-γ)的水平则随[C14 min]BF4剂量的增加而升高。停止染毒30 d后，部分指标略有改善。实验表明[C14 min]BF4长期染毒可引起大鼠免疫功能紊乱，产生免疫毒性。

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