群体感应对细菌生物膜及细菌耐药性影响的研究进展
Research Progress on Influence of Quorum Sensing on Bacterial Biofilm and Bacterial Drug Resistance
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摘要: 群体感应作为微生物间的特殊通信感应系统，通过合成、分泌信号分子控制着整个细菌群体行为。群体感应直接参与细菌生物膜的形成过程，进而影响着细菌耐药性的传播扩散。本文综述了群体感应对生物被膜形成和细菌耐药性的传播扩散的影响，以及群体感应抑制剂在生物被膜形成和抗生素耐药性的传播扩散过程中的作用，并结合国内外研究现状，对细菌耐药性未来研究重点进行了展望。Abstract: Quorum sensing, as a unique communication sensing system among microorganisms, regulates the entire bacterial colony behavior by synthesizing and secreting signal molecules. Quorum sensing directly participates in the formation of bacterial biofilm, and thus affects the spread of bacterial drug resistance. This paper reviews the effects of quorum sensing on biofilm formation and the spread of bacterial drug resistance, as well as the role of quorum sensing inhibitors in biofilm formation and the spread of antibiotic resistance. Combined with the research status quo at home and abroad, the future research focus on bacterial drug resistance is prospected.
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Key words:
- quorum sensing /
- biofilm /
- bacterial drug resistance /
- quorum sensing inhibitor
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