海洋环境中抗生素抗性基因的分布、来源、传播和风险研究
Study on Distribution, Source, Propagation and Risk of Antibiotic Resistance Genes in Marine Environment
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摘要: 当前抗生素抗性基因(antibiotic resistance genes, ARGs)在海洋环境中已普遍存在并广泛传播，具有潜在的生态健康风险。本文综述了国内外近岸海洋环境(河口、沿海地区以及周边海洋)和极地海域中ARGs的分布和归趋特征，总结了医疗废水、陆地径流、污水处理厂尾水和养殖废水等近岸海域ARGs的主要来源，分析了近岸海域ARGs的传播扩散途径和影响因素，探讨了近岸海域ARGs传播对人类健康构成的潜在风险以及评估方法。最后，我们从构建海洋环境中ARGs污染的标准化检测方法、深入研究海洋环境中ARGs的传播转移规律等方面对今后的研究进行了展望。本综述为全面了解海洋环境ARGs污染以及健康风险提供支撑。Abstract: Antibiotic resistance genes (ARGs) have been recognized as emerging contaminants in marine environment due to their frequent occurrence, horizontal-transfer, and high ecological health risks. This review described the distribution and fate of ARGs in nearshore marine environments (estuaries, coastal areas and surrounding seas) and Arctic and Antarctic polar marine environments. We found the main ARGs in nearshore marine environment are from the medical wastewater, land runoff, sewage treatment plant tail water and aquaculture wastewater; we further analyzed the dissemination pathways of ARGs and related influencing factors in nearshore marine environment; we also discussed the available methods for assessing potential risks of ARGs on human health. Finally, we provided the perspectives in terms of establishing standardized detection methods, and strengthening the study of ARGs transport in marine environment. This review provides a comprehensive understanding of ARGs pollution and its health risks in the marine environment.
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Key words:
- antibiotics /
- antibiotics resistance genes /
- mobile genetic elements
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Wu D, Jin L, Xie J W, et al. Inhalable antibiotic resistomes emitted from hospitals: Metagenomic insights into bacterial hosts, clinical relevance, and environmental risks [J]. Microbiome, 2022, 10(1): 19 World Bank Group. Drug resistant infections: A threat to our economic future: Final report [R]. Washington DC: World Bank Group, 2017 Shuai M L, Zhang G Q, Zeng F F, et al. Human gut antibiotic resistome and progression of diabetes [J]. Advanced Science, 2022, 9(11): e2104965 Cassini A, Högberg L D, Plachouras D, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: A population-level modelling analysis [J]. The Lancet Infectious Diseases, 2019, 19(1): 56-66 World Health Organization. Global action plan on antimicrobial resistance 2015 [R]. Geneva: World Health Organization, 2015 Tacconelli E, Sifakis F, Harbarth S, et al. Surveillance for control of antimicrobial resistance [J]. The Lancet Infectious Diseases, 2018, 18(3): e99-e106 Wernli D, Jørgensen P S, Morel C M, et al. Mapping global policy discourse on antimicrobial resistance [J]. BMJ Global Health, 2017, 2(2): e000378 Pruden A, Pei R T, Storteboom H, et al. Antibiotic resistance genes as emerging contaminants: Studies in northern Colorado [J]. Environmental Science & Technology, 2006, 40(23): 7445-7450 Zhao W X, Wang B, Yu G. Antibiotic resistance genes in China: Occurrence, risk, and correlation among different parameters [J]. Environmental Science and Pollution Research, 2018, 25(22): 21467-21482 Qiao M, Ying G G, Singer A C, et al. Review of antibiotic resistance in China and its environment [J]. Environment International, 2018, 110: 160-172 Zhu Y G, Zhao Y, Zhu D, et al. Soil biota, antimicrobial resistance and planetary health [J]. Environment International, 2019, 131: 105059 Ju F, Li B, Ma L P, et al. Antibiotic resistance genes and human bacterial pathogens: Co-occurrence, removal, and enrichment in municipal sewage sludge digesters [J]. Water Research, 2016, 91: 1-10 Zeng S Z, Hou D W, Liu J, et al. Antibiotic supplement in feed can perturb the intestinal microbial composition and function in Pacific white shrimp [J]. Applied Microbiology and Biotechnology, 2019, 103(7): 3111-3122 Ding C S, Jin M, Ma J, et al. Nano-Al2O3 can mediate transduction-like transformation of antibiotic resistance genes in water [J]. Journal of Hazardous Materials, 2021, 405: 124224 Gao H, Zhang L X, Lu Z H, et al. Complex migration of antibiotic resistance in natural aquatic environments [J]. Environmental Pollution, 2018, 232: 1-9 Miranda C D, Godoy F A, Lee M R. Current status of the use of antibiotics and the antimicrobial resistance in the Chilean salmon farms [J]. Frontiers in Microbiology, 2018, 9: 1284 Gao P P, Mao D Q, Luo Y, et al. Occurrence of sulfonamide and tetracycline-resistant bacteria and resistance genes in aquaculture environment [J]. Water Research, 2012, 46(7): 2355-2364 Yuan Q B, Zhai Y F, Mao B Y, et al. Fates of antibiotic resistance genes in a distributed swine wastewater treatment plant [J]. Water Environment Research, 2019, 91(12): 1565-1575 Guo X P, Yang Y, Lu D P, et al. Biofilms as a sink for antibiotic resistance genes (ARGs) in the Yangtze Estuary [J]. Water Research, 2018, 129: 277-286 Chen B W, Liang X M, Nie X P, et al. The role of class I integrons in the dissemination of sulfonamide resistance genes in the Pearl River and Pearl River Estuary, South China [J]. Journal of Hazardous Materials, 2015, 282: 61-67 Niu Z G, Zhang K, Zhang Y. Occurrence and distribution of antibiotic resistance genes in the coastal area of the Bohai Bay, China [J]. Marine Pollution Bulletin, 2016, 107(1): 245-250 Suzuki S, Ogo M, Miller T W, et al. Who possesses drug resistance genes in the aquatic environment?: Sulfamethoxazole (SMX) resistance genes among the bacterial community in water environment of Metro-Manila, Philippines [J]. Frontiers in Microbiology, 2013, 4: 102 Lu J, Zhang Y X, Wu J, et al. Effects of microplastics on distribution of antibiotic resistance genes in recirculating aquaculture system [J]. Ecotoxicology and Environmental Safety, 2019, 184: 109631 Germond A, Kim S J. Genetic diversity of oxytetracycline-resistant bacteria and tet(M) genes in two major coastal areas of South Korea [J]. Journal of Global Antimicrobial Resistance, 2015, 3(3): 166-173 Lu J, Zhang Y X, Wu J, et al. Occurrence and spatial distribution of antibiotic resistance genes in the Bohai Sea and Yellow Sea areas, China [J]. Environmental Pollution, 2019, 252: 450-460 Chen J Y, Su Z G, Dai T J, et al. Occurrence and distribution of antibiotic resistance genes in the sediments of the East China Sea Bays [J]. Journal of Environmental Sciences (China), 2019, 81: 156-167 Li Q W, Na G S, Zhang L X, et al. Effects of corresponding and non-corresponding contaminants on the fate of sulfonamide and quinolone resistance genes in the Laizhou Bay, China [J]. Marine Pollution Bulletin, 2018, 128: 475-482 Ullah R, Yasir M, Bibi F, et al. Taxonomic diversity of antimicrobial-resistant bacteria and genes in the Red Sea coast [J]. Science of the Total Environment, 2019, 677: 474-483 Ng C, Chen H J, Goh S G, et al. Microbial water quality and the detection of multidrug resistant E. coli and antibiotic resistance genes in aquaculture sites of Singapore [J]. Marine Pollution Bulletin, 2018, 135: 475-480 Guo X P, Sun X L, Chen Y R, et al. Antibiotic resistance genes in biofilms on plastic wastes in an estuarine environment [J]. The Science of the Total Environment, 2020, 745: 140916 Dong H, Chen Y L, Wang J, et al. Interactions of microplastics and antibiotic resistance genes and their effects on the aquaculture environments [J]. Journal of Hazardous Materials, 2021, 403: 123961 Hong B, Ba Y B, Niu L, et al. A comprehensive research on antibiotic resistance genes in microbiota of aquatic animals [J]. Frontiers in Microbiology, 2018, 9: 1617 Muziasari W I, Pitkänen L K, Sørum H, et al. The resistome of farmed fish feces contributes to the enrichment of antibiotic resistance genes in sediments below Baltic Sea fish farms [J]. Frontiers in Microbiology, 2016, 7: 2137 Giatsis C, Sipkema D, Smidt H, et al. The impact of rearing environment on the development of gut microbiota in tilapia larvae [J]. Scientific Reports, 2015, 5: 18206 Wang Z Y, Chen Q W, Zhang J Y, et al. Critical roles of cyanobacteria as reservoir and source for antibiotic resistance genes [J]. Environment International, 2020, 144: 106034 Na G S, Wang C X, Gao H, et al. The occurrence of sulfonamide and quinolone resistance genes at the Fildes Peninsula in Antarctica [J]. Marine Pollution Bulletin, 2019, 149: 110503 Tan L, Li L Y, Ashbolt N, et al. Arctic antibiotic resistance gene contamination, a result of anthropogenic activities and natural origin [J]. The Science of the Total Environment, 2018, 621: 1176-1184 Barkovskii A L, Green C, Hurley D. The occurrence, spatial and temporal distribution, and environmental routes of tetracycline resistance and integrase genes in Crassostrea virginica beds [J]. Marine Pollution Bulletin, 2010, 60(12): 2215-2224 Li A L, Chen L J, Zhang Y, et al. Occurrence and distribution of antibiotic resistance genes in the sediments of drinking water sources, urban rivers, and coastal areas in Zhuhai, China [J]. Environmental Science and Pollution Research International, 2018, 25(26): 26209-26217 Suzuki S, Ogo M, Takada H, et al. Contamination of antibiotics and sul and tet(M) genes in veterinary wastewater, river, and coastal sea in Thailand [J]. The Science of the Total Environment, 2021, 791: 148423 胡付品, 郭燕, 朱德妹, 等. 2020年CHINET中国细菌耐药监测[J]. 中国感染与化疗杂志, 2021, 21(4): 377-387 Hu F P, Guo Y, Zhu D M, et al. CHINET surveillance of bacterial resistance: Results of 2020 [J]. Chinese Journal of Infection and Chemotherapy, 2021, 21(4): 377-387 (in Chinese)
Li J N, Cheng W X, Xu L K, et al. Antibiotic-resistant genes and antibiotic-resistant bacteria in the effluent of urban residential areas, hospitals, and a municipal wastewater treatment plant system [J]. Environmental Science and Pollution Research International, 2015, 22(6): 4587-4596 Wang Q, Wang P L, Yang Q X. Occurrence and diversity of antibiotic resistance in untreated hospital wastewater [J]. The Science of the Total Environment, 2018, 621: 990-999 Lucas D, Badia-Fabregat M, Vicent T, et al. Fungal treatment for the removal of antibiotics and antibiotic resistance genes in veterinary hospital wastewater [J]. Chemosphere, 2016, 152: 301-308 Guo X Y, Yan Z, Zhang Y, et al. Behavior of antibiotic resistance genes under extremely high-level antibiotic selection pressures in pharmaceutical wastewater treatment plants [J]. The Science of the Total Environment, 2018, 612: 119-128 Liu X H, Zhang G D, Liu Y, et al. Occurrence and fate of antibiotics and antibiotic resistance genes in typical urban water of Beijing, China [J]. Environmental Pollution, 2019, 246: 163-173 Zhang S C, Huang J Q, Zhao Z C, et al. Hospital wastewater as a reservoir for antibiotic resistance genes: A meta-analysis [J]. Frontiers in Public Health, 2020, 8: 574968 Zhang Q Q, Ying G G, Pan C G, et al. Comprehensive evaluation of antibiotics emission and fate in the river basins of China: Source analysis, multimedia modeling, and linkage to bacterial resistance [J]. Environmental Science & Technology, 2015, 49(11): 6772-6782 Lu Z H, Na G S, Gao H, et al. Fate of sulfonamide resistance genes in estuary environment and effect of anthropogenic activities [J]. The Science of the Total Environment, 2015, 527-528: 429-438 Sala-Comorera L, Nolan T M, Reynolds L J, et al. Bacterial and bacteriophage antibiotic resistance in marine bathing waters in relation to rivers and urban streams [J]. Frontiers in Microbiology, 2021, 12: 718234 Mao D Q, Yu S, Rysz M, et al. Prevalence and proliferation of antibiotic resistance genes in two municipal wastewater treatment plants [J]. Water Research, 2015, 85: 458-466 Lee J, Jeon J H, Shin J, et al. Quantitative and qualitative changes in antibiotic resistance genes after passing through treatment processes in municipal wastewater treatment plants [J]. The Science of the Total Environment, 2017, 605-606: 906-914 Kotlarska E, Łuczkiewicz A, Pisowacka M, et al. Antibiotic resistance and prevalence of class 1 and 2 integrons in Escherichia coli isolated from two wastewater treatment plants, and their receiving waters (Gulf of Gdansk, Baltic Sea, Poland) [J]. Environmental Science and Pollution Research International, 2015, 22(3): 2018-2030 Amos G C, Gozzard E, Carter C E, et al. Validated predictive modelling of the environmental resistome [J]. The ISME Journal, 2015, 9(6): 1467-1476 Chen J Y, Zhang Z Y, Lei Z, et al. Occurrence and distribution of antibiotic resistance genes in the coastal sediments of effluent-receiving areas of WWTPs, China [J]. Bioresource Technology Reports, 2020, 11: 100511 Xu J, Xu Y, Wang H M, et al. Occurrence of antibiotics and antibiotic resistance genes in a sewage treatment plant and its effluent-receiving river [J]. Chemosphere, 2015, 119: 1379-1385 Romero V L, Pons P, Bocco J L, et al. Eudragit E100® potentiates the bactericidal action of ofloxacin against fluoroquinolone-resistant Pseudomonas aeruginosa [J]. FEMS Microbiology Letters, 2012, 334(2): 102-110 Chen H, Liu S, Xu X R, et al. Tissue distribution, bioaccumulation characteristics and health risk of antibiotics in cultured fish from a typical aquaculture area [J]. Journal of Hazardous Materials, 2018, 343: 140-148 Chen B, Hao L J, Guo X Y, et al. Prevalence of antibiotic resistance genes of wastewater and surface water in livestock farms of Jiangsu Province, China [J]. Environmental Science and Pollution Research, 2015, 22(18): 13950-13959 刘锐. 规模化猪场废水典型抗生素抗性基因的调查研究[J]. 家畜生态学报, 2017, 38(11): 68-71 Liu R. A study on typical antibiotic resistance genes in largescale pig farm wastewater [J]. Journal of Domestic Animal Ecology, 2017, 38(11): 68-71 (in Chinese)
Jang H M, Kim Y B, Choi S, et al. Prevalence of antibiotic resistance genes from effluent of coastal aquaculture, South Korea [J]. Environmental Pollution, 2018, 233: 1049-1057 Gao Q X, Li Y L, Qi Z H, et al. Diverse and abundant antibiotic resistance genes from mariculture sites of China’s coastline [J]. The Science of the Total Environment, 2018, 630: 117-125 Jo H, Raza S, Farooq A, et al. Fish farm effluents as a source of antibiotic resistance gene dissemination on Jeju Island, South Korea [J]. Environmental Pollution, 2021, 276: 116764 Zheng D S, Yin G Y, Liu M, et al. A systematic review of antibiotics and antibiotic resistance genes in estuarine and coastal environments [J]. The Science of the Total Environment, 2021, 777: 146009 Li L G, Huang Q, Yin X L, et al. Source tracking of antibiotic resistance genes in the environment—Challenges, progress, and prospects [J]. Water Research, 2020, 185: 116127 Li L G, Yin X L, Zhang T. Tracking antibiotic resistance gene pollution from different sources using machine-learning classification [J]. Microbiome, 2018, 6(1): 93 Chen H Y, Li Y Z, Sun W C, et al. Characterization and source identification of antibiotic resistance genes in the sediments of an interconnected river-lake system [J]. Environment International, 2020, 137: 105538 Aminov R I, Mackie R I. Evolution and ecology of antibiotic resistance genes [J]. FEMS Microbiology Letters, 2007, 271(2): 147-161 Partridge S R, Kwong S M, Firth N, et al. Mobile genetic elements associated with antimicrobial resistance [J]. Clinical Microbiology Reviews, 2018, 31(4): e00088-e00017 Lauren Brito I. Examining horizontal gene transfer in microbial communities [J]. Nature Reviews Microbiology, 2021, 19(7): 442-453 Ilangovan A, Connery S, Waksman G. Structural biology of the Gram-negative bacterial conjugation systems [J]. Trends in Microbiology, 2015, 23(5): 301-310 Zhu Y G, Zhao Y, Li B, et al. Continental-scale pollution of estuaries with antibiotic resistance genes [J]. Nature Microbiology, 2017, 2: 16270 Zhang Y J, Hu H W, Yan H, et al. Salinity as a predominant factor modulating the distribution patterns of antibiotic resistance genes in ocean and river beach soils [J]. The Science of the Total Environment, 2019, 668: 193-203 Jun L J, Jeong J B, Huh M D, et al. Detection of tetracycline-resistance determinants by multiplex polymerase chain reaction in Edwardsiella tarda isolated from fish farms in Korea [J]. Aquaculture, 2004, 240(1-4): 89-100 Wachino J I, Jin W C, Kimura K, et al. Intercellular transfer of chromosomal antimicrobial resistance genes between Acinetobacter baumannii strains mediated by prophages [J]. Antimicrobial Agents and Chemotherapy, 2019, 63(8): e00334-e00319 Calero-Cáceres W, Balcázar J L. Antibiotic resistance genes in bacteriophages from diverse marine habitats [J]. Science of the Total Environment, 2019, 654: 452-455 Thomas C M, Nielsen K M. Mechanisms of, and barriers to, horizontal gene transfer between bacteria [J]. Nature Reviews Microbiology, 2005, 3(9): 711-721 Nonaka L, Yamamoto T, Maruyama F, et al. Interplay of a non-conjugative integrative element and a conjugative plasmid in the spread of antibiotic resistance via suicidal plasmid transfer from an aquaculture Vibrio isolate [J]. PLoS One, 2018, 13(6): e0198613 Walsh T R, Weeks J, Livermore D M, et al. Dissemination of NDM-1 positive bacteria in the New Delhi environment and its implications for human health: An environmental point prevalence study [J]. The Lancet Infectious Diseases, 2011, 11(5): 355-362 Rodríguez-Verdugo A, Lozano-Huntelman N, Cruz-Loya M, et al. Compounding effects of climate warming and antibiotic resistance [J]. iScience, 2020, 23(4): 101024 Joint I, Smale D A. Marine heatwaves and optimal temperatures for microbial assemblage activity [J]. FEMS Microbiology Ecology, 2017, 93(2): fiw243 Gabashvili E, Kobakhidze S, Chkhikvishvili T, et al. Metagenomic and recombination analyses of antimicrobial resistance genes from recreational waters of black sea coastal areas and other marine environments unveil extensive evidence for their both intrageneric and intergeneric transmission across genetically very diverse microbial communities [J]. Marine Genomics, 2022, 61: 100916 Zhang Y P, Niu Z G, Zhang Y, et al. Occurrence of intracellular and extracellular antibiotic resistance genes in coastal areas of Bohai Bay (China) and the factors affecting them [J]. Environmental Pollution, 2018, 236: 126-136 Andersson D I, Hughes D. Microbiological effects of sublethal levels of antibiotics [J]. Nature Reviews Microbiology, 2014, 12(7): 465-478 Shun-Mei E, Zeng J M, Yuan H, et al. Sub-inhibitory concentrations of fluoroquinolones increase conjugation frequency [J]. Microbial Pathogenesis, 2018, 114: 57-62 Na G S, Zhang W R, Zhou S Y, et al. Sulfonamide antibiotics in the Northern Yellow Sea are related to resistant bacteria: Implications for antibiotic resistance genes [J]. Marine Pollution Bulletin, 2014, 84(1-2): 70-75 Wang J H, Lu J, Wu J, et al. Proliferation of antibiotic resistance genes in coastal recirculating mariculture system [J]. Environmental Pollution, 2019, 248: 462-470 Zhang S, Lu J, Wang Y, et al. Insights of metallic nanoparticles and ions in accelerating the bacterial uptake of antibiotic resistance genes [J]. Journal of Hazardous Materials, 2022, 421: 126728 Chen H Y, Bai X M, Li Y Z, et al. Characterization and source-tracking of antibiotic resistomes in the sediments of a peri-urban river [J]. The Science of the Total Environment, 2019, 679: 88-96 Ding J, An X L, Lassen S B, et al. Heavy metal-induced co-selection of antibiotic resistance genes in the gut microbiota of collembolans [J]. The Science of the Total Environment, 2019, 683: 210-215 Chen Y R, Guo X P, Niu Z S, et al. Antibiotic resistance genes (ARGs) and their associated environmental factors in the Yangtze Estuary, China: From inlet to outlet [J]. Marine Pollution Bulletin, 2020, 158: 111360 屈沙沙, 朱会卷, 刘锋平, 等. 微塑料吸附行为及对生物影响的研究进展[J]. 环境卫生学杂志, 2017, 7(1): 75-78 Qu S S, Zhu H J, Liu F P, et al. Adsorption behavior and effect on biont of microplastic [J]. Journal of Environmental Hygiene, 2017, 7(1): 75-78 (in Chinese)
Wang S S, Xue N N, Li W F, et al. Selectively enrichment of antibiotics and ARGs by microplastics in river, estuary and marine waters [J]. The Science of the Total Environment, 2020, 708: 134594 Yang Y Y, Liu G H, Song W J, et al. Plastics in the marine environment are reservoirs for antibiotic and metal resistance genes [J]. Environment International, 2019, 123: 79-86 Liao H P, Li X, Yang Q E, et al. Herbicide selection promotes antibiotic resistance in soil microbiomes [J]. Molecular Biology and Evolution, 2021, 38(6): 2337-2350 文汉卿, 史俊, 寻昊, 等. 抗生素抗性基因在水环境中的分布、传播扩散与去除研究进展[J]. 应用生态学报, 2015, 26(2): 625-635 Wen H Q, Shi J, Xun H, et al. Distribution, dissemination and removal of antibiotic resistant genes (ARGs) in the aquatic environment [J]. Chinese Journal of Applied Ecology, 2015, 26(2): 625-635 (in Chinese)
Sui Q W, Zhang J Y, Chen M X, et al. Distribution of antibiotic resistance genes (ARGs) in anaerobic digestion and land application of swine wastewater [J]. Environmental Pollution, 2016, 213: 751-759 Zhao H X, Yan B, Mo X Y, et al. Prevalence and proliferation of antibiotic resistance genes in the subtropical mangrove wetland ecosystem of South China Sea [J]. MicrobiologyOpen, 2019, 8(11): e871 Tang X J, Lou C L, Wang S X, et al. Effects of long-term manure applications on the occurrence of antibiotics and antibiotic resistance genes (ARGs) in paddy soils: Evidence from four field experiments in south of China [J]. Soil Biology and Biochemistry, 2015, 90: 179-187 Cruz-Loya M, Kang T M, Lozano N A, et al. Stressor interaction networks suggest antibiotic resistance co-opted from stress responses to temperature [J]. The ISME Journal, 2019, 13(1): 12-23 Guo J H, Li J, Chen H, et al. Metagenomic analysis reveals wastewater treatment plants as hotspots of antibiotic resistance genes and mobile genetic elements [J]. Water Research, 2017, 123: 468-478 Jiang C X, Diao X P, Wang H H, et al. Diverse and abundant antibiotic resistance genes in mangrove area and their relationship with bacterial communities—A study in Hainan Island, China [J]. Environmental Pollution, 2021, 276: 116704 李十盛, 高会, 赵富强, 等. 水产养殖环境中抗生素抗性基因的研究进展[J]. 中国环境科学, 2021, 41(11): 5314-5325 Li S S, Gao H, Zhao F Q, et al. Research progress on the occurrence and influencing factors of antibiotic resistance genes in aquaculture environment [J]. China Environmental Science, 2021,41(11): 5314-5325 (in Chinese)
Hatha M, Vivekanandhan A A, Joice G J, et al. Antibiotic resistance pattern of motile aeromonads from farm raised fresh water fish [J]. International Journal of Food Microbiology, 2005, 98(2): 131-134 Kumaran S, Deivasigamani B, Alagappan K, et al. Antibiotic resistant Esherichia coli strains from seafood and its susceptibility to seaweed extracts [J]. Asian Pacific Journal of Tropical Medicine, 2010, 3(12): 977-981 蔡天贵, 张龙, 张晋东. 抗生素抗性基因的生态风险研究进展[J]. 应用生态学报, 2022, 33(5): 1435-1440 Cai T G, Zhang L, Zhang J D. Research advances in ecological risk of antibiotic resistance genes [J]. Chinese Journal of Applied Ecology, 2022, 33(5): 1435-1440 (in Chinese)
Tomova A, Ivanova L, Buschmann A H, et al. Antimicrobial resistance genes in marine bacteria and human uropathogenic Escherichia coli from a region of intensive aquaculture [J]. Environmental Microbiology Reports, 2015, 7(5): 803-809 龙文芳, 李天娇, 黄飞羽, 等. 海水浴场革兰阴性菌的检测及耐药性研究[J]. 环境与健康杂志, 2016, 33(3): 226-228 Long W F, Li T J, Huang F Y, et al. Screening and antibiotic resistance of Gram negative bacteria in bathing beach [J]. Journal of Environment and Health, 2016, 33(3): 226-228 (in Chinese)
Leonard A F, Morris D, Schmitt H, et al. Natural recreational waters and the risk that exposure to antibiotic resistant bacteria poses to human health [J]. Current Opinion in Microbiology, 2022, 65: 40-46 Ma L P, Xia Y, Li B, et al. Metagenomic assembly reveals hosts of antibiotic resistance genes and the shared resistome in pig, chicken, and human feces [J]. Environmental Science & Technology, 2016, 50(1): 420-427 Hendriksen R S, Munk P, Njage P, et al. Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage [J]. Nature Communications, 2019, 10(1): 1124 Zhang Z Y, Zhang Q, Wang T Z, et al. Assessment of global health risk of antibiotic resistance genes [J]. Nature Communications, 2022, 13(1): 1553 -
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